Rafael Maldonado focuses on Pharmacology, Internal medicine, Endocrinology, Cannabinoid receptor and Receptor. His Pharmacology research is multidisciplinary, incorporating perspectives in Opioid receptor, Endogenous opioid, Opioid, Cannabinoid and Nicotine. Within one scientific family, Rafael Maldonado focuses on topics pertaining to Addiction under Opioid, and may sometimes address concerns connected to Ventral tegmental area and Neurochemical.
He has included themes like Self-administration and Neuroprotection in his Endocrinology study. His Cannabinoid receptor research includes themes of PI3K/AKT/mTOR pathway, Knockout mouse, Neuroscience and Endocannabinoid system. His Receptor course of study focuses on Sensitization and Sigma-1 receptor and Stimulation.
Rafael Maldonado mainly focuses on Pharmacology, Internal medicine, Endocrinology, Neuroscience and Receptor. His Pharmacology study incorporates themes from Nicotine, Cannabinoid and Opioid. Rafael Maldonado focuses mostly in the field of Cannabinoid, narrowing it down to topics relating to Cannabinoid receptor and, in certain cases, Endocannabinoid system and Knockout mouse.
His Opioid research focuses on Nociception and how it connects with Neuropathic pain. His research on Internal medicine focuses in particular on Amygdala. His study looks at the relationship between Endocrinology and fields such as Enkephalin, as well as how they intersect with chemical problems.
Rafael Maldonado mostly deals with Internal medicine, Neuroscience, Endocrinology, Prefrontal cortex and Addiction. His Internal medicine and Rheumatology and Receptor investigations all form part of his Internal medicine research activities. His Receptor research integrates issues from Hypothalamus, Pharmacology and MAPK/ERK pathway.
His specific area of interest is Pharmacology, where Rafael Maldonado studies Pharmacodynamics. His Neuroscience research incorporates elements of Endocannabinoid system and Cannabinoid receptor type 2. He interconnects Neuroinflammation, Knockout mouse, Microglia and Gut flora in the investigation of issues within Endocrinology.
His primary scientific interests are in Internal medicine, Neuroscience, Endocrinology, Prefrontal cortex and Nucleus accumbens. His work deals with themes such as Downregulation and upregulation and Cognition, Episodic memory, which intersect with Internal medicine. His study on Neuroscience also encompasses disciplines like
His studies in Endocrinology integrate themes in fields like Elevated plus maze, Antagonist and Microglia. The study incorporates disciplines such as Working memory, Cannabinoid, Anxiety, Hippocampus and Amygdala in addition to Prefrontal cortex. As a member of one scientific family, he mostly works in the field of Dopamine, focusing on Agonist and, on occasion, Opioid.
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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
Hans W. D. Matthes;Rafael Maldonado;Frédéric Simonin;Olga Valverde.
Nature (1996)
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
Dominique Filliol;Sandy Ghozland;Johanna Chluba;Miguel Martin.
Nature Genetics (2000)
Involvement of the endocannabinoid system in drug addiction.
Rafael Maldonado;Olga Valverde;Fernando Berrendero.
Trends in Neurosciences (2006)
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.
Emmanuel Valjent;Emmanuel Valjent;Jean-Christophe Corvol;Christiane Pagès;Marie-Jo Besson.
The Journal of Neuroscience (2000)
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
Rafael Maldonado;Adolfo Saiardi;Olga Valverde;Tarek A. Samad.
Nature (1997)
Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488H and attenuates morphine withdrawal
Frédéric Simonin;Olga Valverde;Claire Smadja;Susan Slowe.
The EMBO Journal (1998)
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
Cristina Mazzucchelli;Chiara Vantaggiato;Alessandro Ciamei;Stefania Fasano.
Neuron (2002)
Involvement of CB1 cannabinoid receptors in emotional behaviour.
Miquel Martin;Catherine Ledent;Marc Parmentier;Rafael Maldonado.
Psychopharmacology (2002)
Neural substrates of opiate withdrawal.
George F. Koob;Rafael Maldonado;Luis Stinus.
Trends in Neurosciences (1992)
Role of different brain structures in the expression of the physical morphine withdrawal syndrome
Rafael Maldonado;L. Stinus;L. H. Gold;George F. Koob.
Journal of Pharmacology and Experimental Therapeutics (1992)
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Publications: 63
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