Phang Lang Chen

What is he best known for?

The fields of study he is best known for:

• Gene
• DNA
• Enzyme

His scientific interests lie mostly in Molecular biology, Cell biology, Cell cycle, Tumor suppressor gene and DNA repair. His work deals with themes such as Retinoblastoma, Gene, Exon, Cyclin D1 and Nuclear protein, which intersect with Molecular biology. His Cell biology research incorporates themes from Transcription factor, LIM domain, Zinc finger, RING finger domain and DNA.

His study in Cell cycle is interdisciplinary in nature, drawing from both Telomere, Telomeric Repeat Binding Protein 1 and Telomerase. Phang Lang Chen combines subjects such as In vitro, Non-homologous end joining, Recombination, Homologous recombination and Suppressor with his study of Tumor suppressor gene. His DNA repair research is multidisciplinary, incorporating perspectives in Mutation, Ataxia telangiectasia and Rad3 related and DNA damage.

His most cited work include:

• The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. (1339 citations)
• Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells (721 citations)
• Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response (567 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Molecular biology, Cell biology, DNA damage, Cancer research and DNA repair. The study incorporates disciplines such as DNA, Phosphorylation, Retinoblastoma, Cyclin D1 and Nuclear protein in addition to Molecular biology. His Retinoblastoma study combines topics from a wide range of disciplines, such as Tumor suppressor gene and Gene expression.

His studies deal with areas such as Carcinogenesis and Cell cycle, Retinoblastoma protein, Cell cycle checkpoint as well as Cell biology. His research integrates issues of G2-M DNA damage checkpoint, Mutation, Reactive oxygen species, MDC1 and Rad50 in his study of DNA damage. His Cancer research research focuses on Breast cancer and how it connects with Antibody, Function and Gene product.

He most often published in these fields:

• Molecular biology (51.14%)
• Cell biology (31.82%)
• DNA damage (28.41%)

What were the highlights of his more recent work (between 2007-2019)?

• Cell biology (31.82%)
• DNA damage (28.41%)
• DNA repair (17.05%)

In recent papers he was focusing on the following fields of study:

Cell biology, DNA damage, DNA repair, Mitosis and CHEK1 are his primary areas of study. His Cell biology research is multidisciplinary, relying on both Cancer and Cell growth. His DNA damage research integrates issues from Oxidative stress, Reactive oxygen species and Cancer research.

His research in DNA repair intersects with topics in Molecular biology and Cell cycle. In his works, he conducts interdisciplinary research on Molecular biology and Streptavidin. His Mitosis research focuses on subjects like Programmed cell death, which are linked to Nude mouse, Cell culture, Mechanism of action and Oncogene.

Between 2007 and 2019, his most popular works were:

• Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease (98 citations)
• Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. (85 citations)
• Never-in-mitosis related Kinase 1 functions in DNA damage response and checkpoint control (67 citations)

In his most recent research, the most cited papers focused on:

• Gene
• DNA
• Enzyme

Phang Lang Chen spends much of his time researching Cell biology, Biochemistry, Cell growth, Cancer and Programmed cell death. The concepts of his Cell biology study are interwoven with issues in Cell cycle checkpoint, DNA damage, Cysteine, Selenocysteine and Unfolded protein response. Phang Lang Chen has researched DNA damage in several fields, including Heat shock protein, Oxidative stress, Reactive oxygen species, DNA repair and Cell cycle.

His Cell growth research incorporates elements of Cancer research, Cancer cell, Apoptosis, Progenitor cell and RAD51. His Nude mouse study in the realm of Cancer interacts with subjects such as Spindle checkpoint. His Programmed cell death research is multidisciplinary, incorporating perspectives in Cell culture, Mechanism of action, Oncogene, Mitosis and Small molecule.