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D-Index & Metrics

Molecular Biology

D-Index
69
Citations
25044
World Ranking
1450
National Ranking
738

Overview

Eva Y.-H. P. Lee is affiliated with the University of California, Irvine in the United States. Their research spans multiple fields, primarily in Medicine and Chemistry, with focused subfields including Organic Chemistry, Oncology, Immunology, Epidemiology, and Neurology.

The scientist's main research topics include:

  • Synthesis and biological activity
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Psoriasis: Treatment and Pathogenesis
  • Pancreatic and Hepatic Oncology Research
  • Neuroendocrine Tumor Research Advances
  • Neuroblastoma Research and Treatments

Frequent coauthors collaborating with Eva Y.-H. P. Lee include:

  • Y.M. Chen
  • Chun-Mei Hu
  • Yu-Wen Tien
  • Wen-Hwa Lee
  • Yizhou Dong

Publications by Eva Y.-H. P. Lee are found in journals such as UNC Libraries, Science Translational Medicine, and the British Journal of Cancer. The scientist has contributed research articles across these venues, with a prevalence of works in the UNC Libraries repository.

Representative recent papers by Eva Y.-H. P. Lee include:

  • Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer (2021, Science Translational Medicine)
  • Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors (2024, British Journal of Cancer)
  • Antitumor Agents. 289. Design, Synthesis, and Anti-Breast Cancer Activity in Vivo of 4-Amino-2 H -benzo[h]chromen-2-one and 4-Amino-7,8,9,10-tetrahydro-2 H -benzo[h]chromen-2-one Analogues with Improved Water Solubility (2020, UNC Libraries)
  • Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents (2020, UNC Libraries)

The body of work shows a cross-disciplinary engagement involving organic chemistry approaches to drug synthesis alongside clinical oncology research, particularly focusing on cancer types such as pancreatic, breast, and neuroendocrine tumors. The research landscape also includes immunological aspects relevant to cancer immunotherapy and immune response mechanisms.

Best Publications

  • Human retinoblastoma susceptibility gene: cloning, identification, and sequence

    Wen-Hwa Lee;Robert Bookstein;Frank Hong;Lih-Jiuan Young

  • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.

    Eva Y.-H. P. Lee;Chi-Yao Chang;Nanpin Hu;Yi-Chun J. Wang

  • Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

    Huei-Jen Su Huang;Jiing-Kuan Yee;Jin-Yuh Shew;Phang-Lang Chen

  • The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

    David W. Goodrich;Nan Ping Wang;Yue-Wei Qian;Eva Y.-H.P. Lee

  • The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

    Wen-Hwa Lee;Jin-Yuh Shew;Frank D. Hong;Theodore W. Sery

  • Inactivation of the retinoblastoma susceptibility gene in human breast cancers.

    Eva Y.H.P. Lee;Hoang To;Jin Yuh Shew;Robert Bookstein

  • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

    Parvin T. Yazdi;Yi Wang;Song Zhao;Nimitt Patel

  • Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

    Song Zhao;Yi-Chinn Weng;Shyng-Shiou F. Yuan;Shyng-Shiou F. Yuan;Yi-Tzu Lin

  • BRCA2 Is Required for Ionizing Radiation-induced Assembly of Rad51 Complex in Vivo

    Shyng Shiou F Yuan;Sou Ying Lee;Gang Chen;Meihua Song

  • Oncogenes and Tumor Suppressor Genes

    Eva Y.H.P. Lee;William J. Muller

  • DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.

    Gopal K. Dasika;Suh Chin J. Lin;Song Zhao;Patrick Sung

  • Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

    Kelly M. Trujillo;Shyng Shiou F. Yuan;Eva Y.H.P. Lee;Patrick Sung

  • The Divergent Robo Family Protein Rig-1/Robo3 Is a Negative Regulator of Slit Responsiveness Required for Midline Crossing by Commissural Axons

    Christelle Sabatier;Christelle Sabatier;Andrew S Plump;Le Ma;Le Ma;Katja Brose

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

    Shang Li;Nicholas S.Y. Ting;Lei Zheng;Phang Lang Chen

  • Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata.

    E.Y.H. Lee;G. Parry;M.J. Bissell

  • Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

    Eva Y H P Lee;Nanpin Hu;Shyng Shiou F Yuan;Laura A. Cox

  • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis

    Alexandru Almasan;Yuxin Yin;Yuxin Yin;Ruth E. Kelly;Eva Y. H. P. Lee

  • Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion

    E.Y.H.P. Lee;W.H. Lee;C.S. Kaetzel;G. Parry

  • Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.

    Nanpin Hu;A. Gutsmann;D. C. Herbert;A. Bradley

Frequent Co-Authors

Wen-Hwa Lee
Wen-Hwa Lee Academia Sinica
Yung-Ming Jeng
Yung-Ming Jeng National Taiwan University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Phang Lang Chen
Phang Lang Chen University of California, Irvine
Kenneth F. Bastow
Kenneth F. Bastow University of North Carolina at Chapel Hill
Larry A. Donoso
Larry A. Donoso Wills Eye Hospital
Allan Bradley
Allan Bradley University of Cambridge
Ellis R. Levin
Ellis R. Levin University of California, Irvine
Patrick Sung
Patrick Sung The University of Texas Health Science Center at San Antonio
Tung-Tien Sun
Tung-Tien Sun New York University

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