Penny A. Handford

Overview

Best Publications

• Somatic mutant clones colonize the human esophagus with age

  Iñigo Martincorena;Joanna C. Fowler;Agnieszka Wabik;Andrew R. J. Lawson

  975
  Citations

• Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.

  A.K Downing;V Knott;J.M Werner;C.M Cardy

  544
  Citations

• The molecular genetics of Marfan syndrome and related disorders

  Peter N. Robinson;E. Arteaga-Solis;C. Baldock;G. Collod-Béroud

  493
  Citations

• The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.

  Zihe Rao;P. Handford;M. Mayhew;V. Knott

  415
  Citations

• Key residues involved in calcium-binding motifs in EGF-like domains.

  Handford Pa;Mayhew M;Baron M;Winship Pr;Winship Pr

  370
  Citations

• A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans -activation and cis -inhibition

  Jemima Cordle;Steven Johnson;Joyce Zi Yan Tay;Pietro Roversi

  312
  Citations

• The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.

  D. J. G. Rees;I. M. Jones;P. A. Handford;S. J. Walter

  300
  Citations

• Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome

  B. L. Loeys;B. L. Loeys;E. E. Gerber;D. Riegert-Johnson;S. Iqbal

  299
  Citations

• CRB1 mutation spectrum in inherited retinal dystrophies.

  Anneke I. den Hollander;Jason Davis;Saskia D. van der Velde-Visser;Marijke N. Zonneveld

  245
  Citations

• Notch receptor-ligand binding and activation: insights from molecular studies.

  Chandramouli R. Chillakuri;Devon Sheppard;Susan M. Lea;Penny A. Handford

  235
  Citations

• The first EGF-like domain from human factor IX contains a high-affinity calcium binding site.

  P A Handford;M Baron;M Mayhew;A Willis

  233
  Citations

• Mutations in the TGFβ Binding-Protein-Like Domain 5 of FBN1 Are Responsible for Acromicric and Geleophysic Dysplasias

  Carine Le Goff;Clémentine Mahaut;Lauren W Wang;Slimane Allali

  229
  Citations

• Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc.

  Jing Yu;Uday Tirlapur;Jeremy Fairbank;Penny Handford

  195
  Citations

• Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils.

  X Yuan;A K Downing;V Knott;P A Handford

  182
  Citations

• The CD46-Jagged1 interaction is critical for human TH1 immunity

  Gaëlle Le Friec;Devon Sheppard;Pat Whiteman;Christian M. Karsten

  168
  Citations

• CALCIUM BINDING PROPERTIES OF AN EPIDERMAL GROWTH FACTOR-LIKE DOMAIN PAIR FROM HUMAN FIBRILLIN-1

  V Knott;A K Downing;C M Cardy;P Handford

  161
  Citations

• Structural and functional properties of the human notch-1 ligand binding region.

  S Hambleton;N V Valeyev;A Muranyi;V Knott

  160
  Citations

• Fibrillin: from domain structure to supramolecular assembly.

  P.A Handford;A.K Downing;D.P Reinhardt;L.Y Sakai

  155
  Citations

• Allelic variation in normal human FBN1 expression in a family with Marfan syndrome: a potential modifier of phenotype?

  Sarah Hutchinson;Andre Furger;Dorothy Halliday;Daniel P. Judge

  154
  Citations

• The Calcium Binding Properties and Molecular Organization of Epidermal Growth Factor-like Domains in Human Fibrillin-1

  P. Handford;A. K. Downing;Zihe Rao;D. R. Hewett

  146
  Citations