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D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
32428
World Ranking
1542
National Ranking
866

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Robert P. Mecham is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. Within these broad fields, key subfields of study include Molecular Biology, Genetics, Pulmonary and Respiratory Medicine, Cancer Research, and Cardiology and Cardiovascular Medicine.

The main topics of their work involve connective tissue disorders research, aortic aneurysm repair treatments, protease and inhibitor mechanisms, cardiovascular health and disease prevention, aortic disease and treatment approaches, infectious aortic and vascular conditions, and proteoglycans and glycosaminoglycans research.

Frequent coauthors with whom Robert P. Mecham has collaborated include Jessica E. Wagenseil, Carmen M. Halabi, Chien-Jung Lin, Thomas J. Broekelmann, and Robyn Roth.

Their publications have appeared regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Matrix Biology, The FASEB Journal, and Acta Biomaterialia.

Recent papers by Robert P. Mecham include:

  • SVEP1 is a human coronary artery disease locus that promotes atherosclerosis, 2021, Science Translational Medicine
  • Macrophage secretion of miR-106b-5p causes renin-dependent hypertension, 2020, Nature Communications
  • A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase, 2020, Science Advances
  • Stem cell derived extracellular vesicles for vascular elastic matrix regenerative repair, 2020, Acta Biomaterialia
  • Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers, 2020, Matrix Biology

Robert P. Mecham has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2007.

Best Publications

  • Vascular Extracellular Matrix and Arterial Mechanics

    Jessica E. Wagenseil;Robert P. Mecham

  • Elastin is an essential determinant of arterial morphogenesis

    Dean Y. Li;Benjamin Brooke;Elaine C. Davis;Robert P. Mecham

  • Extracellular matrix 4: the elastic fiber.

    Joel Rosenbloom;William R. Abrams;Robert Mecham

  • Chemotactic activity of elastin-derived peptides.

    R. M. Senior;G. L. Griffin;Robert Mecham

  • TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

    Connie M. Ng;Alan Cheng;Loretha A. Myers;Francisco Martinez-Murillo

  • Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.

    R. W. Thompson;D. R. Holmes;R. A. Mertens;Shixiong Liao

  • Elastin fragments drive disease progression in a murine model of emphysema

    A. McGarry Houghton;Pablo A. Quintero;David L. Perkins;Dale K. Kobayashi

  • Elastin in large artery stiffness and hypertension

    Jessica E. Wagenseil;Robert P. Mecham

  • New insights into elastic fiber assembly

    Jessica E. Wagenseil;Robert P. Mecham

  • Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes.

    R M Senior;G L Griffin;R P Mecham;D S Wrenn

  • Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices

    Hui Zhang;S. D. Apfelroth;Wei Hu;E. C. Davis

  • CELLULAR AND MOLECULAR MECHANISMS OF PULMONARY VASCULAR REMODELING

    K. R. Stenmark;R. P. Mecham

  • Novel arterial pathology in mice and humans hemizygous for elastin

    Dean Y. Li;Gilles Faury;Douglas G. Taylor;Elaine C. Davis

  • Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

    Scott P. Heximer;Russell H. Knutsen;Xiaoguang Sun;Kevin M. Kaltenbronn

  • Lysyl oxidase is required for vascular and diaphragmatic development in mice.

    Ian K. Hornstra;Shonyale Birge;Barry Starcher;Allen J. Bailey

  • The Elastin Receptor: A Galactoside-Binding Protein

    Aleksander Hinek;David S. Wrenn;Robert P. Mecham;Samuel H. Barondes

  • Extracellular matrix assembly and structure

    Peter D. Yurchenco;David E. Birk;Robert P. Mecham

  • Receptors for laminin on mammalian cells.

    Robert P. Mecham

  • Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency

    Gilles Faury;Mylène Pezet;Russell H. Knutsen;Walter A. Boyle

  • Elastin Degradation by Matrix Metalloproteinases CLEAVAGE SITE SPECIFICITY AND MECHANISMS OF ELASTOLYSIS

    Robert P. Mecham;Thomas J. Broekelmann;Catherine J. Fliszar;Steven D. Shapiro

Frequent Co-Authors

William C. Parks
William C. Parks Cedars-Sinai Medical Center
Elaine C. Davis
Elaine C. Davis McGill University
Kurt R. Stenmark
Kurt R. Stenmark University of Colorado Anschutz Medical Campus
Robert M. Senior
Robert M. Senior Washington University in St. Louis
Joel Rosenbloom
Joel Rosenbloom Thomas Jefferson University
William R. Abrams
William R. Abrams New York University
Pyong Woo Park
Pyong Woo Park Boston Children's Hospital
Colin G. Nichols
Colin G. Nichols Washington University in St. Louis
Dieter P. Reinhardt
Dieter P. Reinhardt McGill University
Francesco Ramirez
Francesco Ramirez Icahn School of Medicine at Mount Sinai

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