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Molecular Biology

D-Index
48
Citations
14679
World Ranking
2660
National Ranking
1297

Overview

Tom K. Kerppola is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these broad areas, they have contributed notably to Molecular Biology, Immunology, Rheumatology, and Genetics.

Their research focuses on several scientific topics, including:

  • Genomics, phytochemicals, and oxidative stress
  • Immune Cell Function and Interaction
  • Inflammasome and immune disorders
  • GDF15 and Related Biomarkers
  • Epigenetics and DNA Methylation
  • IL-33, ST2, and ILC Pathways
  • RNA regulation and disease

Kerppola's recent publications include the following papers:

  • Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription, 2021, The Journal of Immunology
  • Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment, 2022, Immunology
  • Keap1 binds cytokine promoters upon virus infection and moderates their induction by recruiting NFκB p50 and G9a-GLP, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFкB p50 recruitment, and H3K9me2 deposition, 2022, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent coauthor is Veronica Elizabeth Burns, with whom they have collaborated on multiple publications.

Kerppola's work has been published in several venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Immunology

Best Publications

  • Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation

    Chang Deng Hu;Yurii Chinenov;Tom K. Kerppola

  • Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis.

    Chang Deng Hu;Tom K. Kerppola

  • The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.

    Jain J;McCaffrey Pg;Miner Z;Miner Z;Kerppola Tk

  • Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity

    Yurii Chinenov;Tom K Kerppola

  • Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells

    Tom K. Kerppola

  • Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells

    Tom K Kerppola

  • The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription

    Natalie Von Der Lehr;Sara Johansson;Siqin Wu;Fuad Bahram

  • Visualization of molecular interactions by fluorescence complementation

    Tom K. Kerppola

  • Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

    Patricia G. McCaffrey;Chun Luo;Tom K. Kerppola;Jugnu Jain

  • Fos-Jun heterodimers and jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity

    Tom K. Kerppola;Tom Curran

  • Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.

    Linda M Robertson;Tom K Kerppola;Montserrat Vendrell;Daniel Luk

  • Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

    Wei Hsu;T. K. Kerppola;Phang-Lang Chen;T. Curran

  • Visualization of molecular interactions using bimolecular fluorescence complementation analysis: Characteristics of protein fragment complementation

    Tom K. Kerppola

  • DNA bending by Fos and Jun: the flexible hinge model

    Tom K. Kerppola;Tom Curran

  • Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.

    Kerppola Tk;Curran T

  • The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

    Laurie A. Penix;Marianne T. Sweetser;William M. Weaver;James P. Hoeffler

  • Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.

    T K Kerppola;D Luk;T Curran

  • Visualization of Myc/Max/Mad Family Dimers and the Competition for Dimerization in Living Cells

    Asya V. Grinberg;Chang Deng Hu;Tom K. Kerppola

  • Selective DNA bending by a variety of bZIP proteins.

    T K Kerppola;T Curran

  • Polycomb group complexes – many combinations, many functions

    Tom K. Kerppola

Frequent Co-Authors

Tom Curran
Tom Curran Children's Mercy Hospital
Selina Chen-Kiang
Selina Chen-Kiang Cornell University
Phang Lang Chen
Phang Lang Chen University of California, Irvine
Deyu Fang
Deyu Fang Northwestern University
Ronald W. Holz
Ronald W. Holz University of Michigan–Ann Arbor
Michael A. Sutton
Michael A. Sutton University of Michigan–Ann Arbor
Surendra Sharma
Surendra Sharma Brown University
Yoshiaki Ito
Yoshiaki Ito Kyoto University
Richard J. Smeyne
Richard J. Smeyne Thomas Jefferson University
Anjana Rao
Anjana Rao La Jolla Institute For Allergy & Immunology

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