His primary scientific interests are in Transcription factor, Molecular biology, Bimolecular fluorescence complementation, Protein-fragment complementation assay and Protein–protein interaction. He has researched Transcription factor in several fields, including Cyclosporin a and Transcription. His Transcription study combines topics from a wide range of disciplines, such as Cooperativity and c-Fos.
His studies deal with areas such as DNA methylation, ATF/CREB, CREB, Proteasome and Response element as well as Molecular biology. The concepts of his Bimolecular fluorescence complementation study are interwoven with issues in Cell culture, Biophysics, Fluorescence microscope, Cell type and Cell biology. His Cell biology research includes elements of Protein structure and Genetics.
His primary areas of study are Molecular biology, Cell biology, Bimolecular fluorescence complementation, Transcription factor and Transcription. His Molecular biology research is multidisciplinary, incorporating perspectives in DNA, DNA-binding protein, Promoter, Leucine zipper and Binding site. His studies in Cell biology integrate themes in fields like Cell, Cell type and Protein subunit.
His Bimolecular fluorescence complementation study also includes fields such as
Tom K. Kerppola focuses on Cell biology, Transcription, Molecular biology, Internal medicine and Endocrinology. His research in Cell biology intersects with topics in Transcription Activation, PRC1 and Cooperative binding. His work on E-box as part of general Transcription study is frequently linked to Embryoid body, therefore connecting diverse disciplines of science.
Tom K. Kerppola interconnects Regulation of gene expression and Transcription factor in the investigation of issues within Molecular biology. As part of one scientific family, he deals mainly with the area of Regulation of gene expression, narrowing it down to issues related to the Drosophila Protein, and often Bimolecular fluorescence complementation. His Transcription factor research is multidisciplinary, incorporating elements of Chromatin, Polytene chromosome and Transcription preinitiation complex.
The scientist’s investigation covers issues in Molecular biology, Embryoid body, E-box, TBX1 and Response element. Tom K. Kerppola combines subjects such as Polytene chromosome, Signal transduction, Ecdysone, Prothoracic gland and Regulation of gene expression with his study of Molecular biology. His Embryoid body investigation overlaps with other areas such as Transcription, Promoter and Cellular differentiation.
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Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation
Chang Deng Hu;Yurii Chinenov;Tom K. Kerppola.
Molecular Cell (2002)
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Jugnu Jain;Patricia G. McCafffrey;Zoe Miner;Zoe Miner;Tom K. Kerppola.
Nature (1993)
Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis.
Chang Deng Hu;Tom K. Kerppola.
Nature Biotechnology (2003)
Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity
Yurii Chinenov;Tom K Kerppola.
Oncogene (2001)
Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells
Tom K. Kerppola.
Annual Review of Biophysics (2008)
Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells
Tom K Kerppola.
Nature Protocols (2006)
The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription
Natalie Von Der Lehr;Sara Johansson;Siqin Wu;Fuad Bahram.
Molecular Cell (2003)
Visualization of molecular interactions by fluorescence complementation
Tom K. Kerppola.
Nature Reviews Molecular Cell Biology (2006)
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
PG McCaffrey;C Luo;TK Kerppola;J Jain.
Science (1993)
Fos-Jun heterodimers and jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity
Tom K. Kerppola;Tom Curran.
Cell (1991)
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