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D-Index & Metrics

Molecular Biology

D-Index
66
Citations
24637
World Ranking
1600
National Ranking
809

Overview

Richard Baer is affiliated with Columbia University in the United States and has contributed extensively to research in the fields of biochemistry, genetics, molecular biology, and medicine.

Their work spans various subfields including molecular biology, oncology, cancer research, electrical and electronic engineering, and immunology. The main topics covered by their research include DNA repair mechanisms, CRISPR and genetic engineering, PARP inhibition in cancer therapy, cancer-related molecular pathways, chromatin remodeling and cancer, peptidase inhibition and analysis, and integrated circuits and semiconductor failure analysis.

Baer has published in several scientific venues, with frequent contributions to:

  • Proceedings of the National Academy of Sciences
  • Cell Reports
  • Molecular Cell
  • Cell
  • Nature Communications

Their recent papers highlight investigations into molecular and cellular processes related to cancer and genome stability. These include:

  • REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps, 2021, Molecular Cell
  • SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion, 2024, Cell
  • Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy, 2023, Nature Communications
  • Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, 2023, Proceedings of the National Academy of Sciences
  • CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining, 2020, Proceedings of the National Academy of Sciences

Frequent collaborators in research include Alberto Ciccia, Shan Zha, Angelo Taglialatela, Foon Wu-Baer, and Zhengping Shao, indicating a consistent multidisciplinary research network.

Best Publications

  • Ferroptosis as a p53-mediated activity during tumour suppression

    Le Jiang;Ning Kon;Tongyuan Li;Shang–Jui Wang

  • DNA sequence and expression of the B95-8 Epstein—Barr virus genome

    R. Baer;R. Baer;A. T. Bankier;M. D. Biggin;P. L. Deininger

  • Human CtIP promotes DNA end resection

    Alessandro A. Sartori;Claudia Lukas;Julia Coates;Martin Mistrik

  • Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

    Muyang Li;Christopher L. Brooks;Foon Wu-Baer;Delin Chen

  • Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

    Tongyuan Li;Ning Kon;Le Jiang;Minjia Tan

  • Identification of a RING protein that can interact in vivo with the BRCA1 gene product.

    Leeju C. Wu;Zhuo Wei Wang;Julia Tsou Tsan;Monique A. Spillman

  • The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

    Xin Yu;Leeju C. Wu;Anne M. Bowcock;Ami Aronheim

  • Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

    Lamorna Brown;Jiin Tsuey Cheng;Qi Chen;Michael J. Siciliano

  • Diversity and rearrangement of the human T cell rearranging γ genes: nine germ-line variable genes belonging to two subgroups

    M.-P. LeFranc;A. Forster;R. Baer;M.A. Stinson

  • A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

    Aude Dupré;Louise Boyer-Chatenet;Louise Boyer-Chatenet;Rose M Sattler;Ami P Modi

  • The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

    Q. Chen;J.T. Cheng;L.H. Tasi;N. Schneider

  • The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

    Foon Wu-Baer;Karen Lagrazon;Wei Yuan;Richard Baer

  • The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.

    Richard Baer;Thomas Ludwig

  • DNA double-strand break repair pathway choice and cancer.

    Tomas Aparicio;Richard Baer;Jean Gautier

  • Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.

    T. H. Rabbitts;P. H. Hamlyn;R. Baer

  • Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.

    Isobel Wadman;Jinxing Li;Robert O. Bash;Alan Forster

  • Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

    R. C. Larson;I. Lavenir;T. A. Larson;R. Baer

  • BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

    Samuel F. Bunting;Elsa Callén;Marina L. Kozak;Jung Min Kim

  • The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells

    V E Valge-Archer;H Osada;A J Warren;A Forster

  • BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.

    Xiaochun Yu;Shuang Fu;Maoyi Lai;Richard Baer

Frequent Co-Authors

Thomas Ludwig
Thomas Ludwig Columbia University
Jean Gautier
Jean Gautier Columbia University
Maria Jasin
Maria Jasin Memorial Sloan Kettering Cancer Center
Melanie H. Cobb
Melanie H. Cobb The University of Texas Southwestern Medical Center
Anne M. Bowcock
Anne M. Bowcock Icahn School of Medicine at Mount Sinai
Wei Gu
Wei Gu Columbia University
André Nussenzweig
André Nussenzweig National Institutes of Health
William M. Crist
William M. Crist University of Oklahoma
Max E. Gottesman
Max E. Gottesman Columbia University Medical Center
Tanya T. Paull
Tanya T. Paull The University of Texas at Austin

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