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Biology and Biochemistry

D-Index
73
Citations
21418
World Ranking
5883
National Ranking
2784

Overview

Thomas Ludwig is affiliated with Columbia University in the United States. Their research spans across multiple fields with a notable focus on Biochemistry, Genetics and Molecular Biology, as well as Earth and Planetary Sciences.

The scientist has contributed to a range of topics that include:

  • Geological and Geochemical Analysis
  • Astro and Planetary Science
  • High-pressure geophysics and materials
  • Genetic Associations and Epidemiology
  • Planetary Science and Exploration
  • Cancer Genomics and Diagnostics
  • Geology and Paleoclimatology Research

Thomas Ludwig's publication record features important works such as:

  • Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts (2020), published in The Lancet Rheumatology
  • The old, unique C1 chondrite Flensburg - Insight into the first processes of aqueous alteration, brecciation, and the diversity of water-bearing parent bodies and lithologies (2020), published in Geochimica et Cosmochimica Acta
  • Heritable defects in telomere and mitotic function selectively predispose to sarcomas (2023), published in Science
  • Al-Mg and U-Pb chronological records of Erg Chech 002 ungrouped achondrite meteorite (2022), published in Geochimica et Cosmochimica Acta
  • A hidden Rodinian lithospheric keel beneath Zealandia, Earth's newly recognized continent (2021), published in Geology

The researcher frequently collaborates with several co-authors including Emmanuelle Génin, Gaëlle Marenne, Anthony F. Herzig, Jean-François Deleuze, and Ozvan Bocher.

Most of their studies have appeared in the following publication venues:

  • Geochimica et Cosmochimica Acta
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Lancet Rheumatology
  • Science
  • Annals of Neurology

Their work integrates subfields such as Genetics, Geophysics, Molecular Biology, Astronomy and Astrophysics, and Immunology, reflecting a multidisciplinary approach.

Best Publications

  • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

    Zhenbang Chen;Lloyd C. Trotman;David Shaffer;Hui Kuan Lin

  • Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

    Tongyuan Li;Ning Kon;Le Jiang;Minjia Tan

  • Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

    Ulf Klein;Stefano Casola;Giorgio Cattoretti;Qiong Shen

  • Generation of pluripotent stem cells from patients with type 1 diabetes.

    René Maehr;Shuibing Chen;Melinda Snitow;Thomas Ludwig

  • Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

    Rachael M. Easton;Han Cho;Kristin Roovers;Diana W. Shineman

  • Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

    T Ludwig;D L Chapman;V E Papaioannou;A Efstratiadis

  • Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.

    Thomas Ludwig;Jonathan Eggenschwiler;Peter Fisher;A.Joseph D'Ercole

  • Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2

    Giuliano Ciarimboli;Thomas Ludwig;Detlef Lang;Hermann Pavenstädt

  • The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

    Roberto Coppari;Masumi Ichinose;Masumi Ichinose;Charlotte E. Lee;Abigail E. Pullen

  • IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer

    Thomas A Mace;Reena Shakya;Jason R Pitarresi;Benjamin Swanson

  • Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

    Lao H Saal;Sofia K Gruvberger-Saal;Camilla Persson;Kristina Lövgren

  • Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

    Carl De Luca;Timothy J. Kowalski;Yiying Zhang;Joel K. Elmquist

  • The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.

    Richard Baer;Thomas Ludwig

  • Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

    Gisela Weskamp;Hui Cai;Thomas A. Brodie;Shigeki Higashyama

  • BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

    Samuel F. Bunting;Elsa Callén;Marina L. Kozak;Jung Min Kim

  • Involvement of human MOF in ATM function

    Arun Gupta;Girdhar G. Sharma;Charles S H Young;Manjula Agarwal

  • BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

    Reena Shakya;Latarsha J. Reid;Colleen R. Reczek;Francesca Cole

  • In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome.

    J Tooze;M Hollinshead;T Ludwig;K Howell

  • Glioblastoma cells release factors that disrupt blood-brain barrier features

    Stefan W. Schneider;Thomas Ludwig;Lars Tatenhorst;Stephan Braune

  • The Mammalian Ortholog of Drosophila MOF That Acetylates Histone H4 Lysine 16 Is Essential for Embryogenesis and Oncogenesis

    Arun Gupta;T. Geraldine Guerin-Peyrou;Girdhar G. Sharma;Changwon Park

Frequent Co-Authors

Richard Baer
Richard Baer Columbia University
Argiris Efstratiadis
Argiris Efstratiadis Biomedical Research Foundation of the Academy of Athens
Tej K. Pandita
Tej K. Pandita Houston Methodist
Raj K. Pandita
Raj K. Pandita Houston Methodist
Peter Fisher
Peter Fisher University of Liverpool
Streamson C. Chua
Streamson C. Chua Albert Einstein College of Medicine
Katerina Politi
Katerina Politi Yale University
Wei Gu
Wei Gu Columbia University
Peter Lobel
Peter Lobel Rutgers, The State University of New Jersey

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