World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
21661
World Ranking
7669
National Ranking
3495

Overview

Streamson C. Chua is affiliated with the Albert Einstein College of Medicine in the United States. Their research spans several interconnected areas within medicine, neuroscience, and biochemistry, genetics, and molecular biology.

Their published work covers a range of topics including regulation of appetite and obesity, biochemical analysis and sensing techniques, pancreatic function and diabetes, diet, metabolism, and disease, photoreceptor and optogenetics research, circadian rhythm and melatonin, and adipokines, inflammation, and metabolic diseases.

More specifically, their research interests delve into subfields such as endocrine and autonomic systems, nutrition and dietetics, surgery, molecular biology, and physiology.

Key papers by Streamson C. Chua include:

  • Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production, 2020, Nature Communications
  • Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids, 2020, Journal of Biological Chemistry
  • Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice, 2025, Nature Communications
  • The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis, 2023, Journal of Clinical Investigation
  • Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes, 2021, Developmental Cell

Their collaborations frequently include researchers such as Gary J. Schwartz, Young-Hwan Jo, Jeffrey E. Pessin, Jiyeon Hwang, and Junichi Okada.

Streamson C. Chua's publications have appeared in journals such as Nature Communications, Journal of Biological Chemistry, Journal of Clinical Investigation, Developmental Cell, and the American Journal of Physiology-Endocrinology and Metabolism.

Best Publications

  • Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

    Streamson C. Chua;Wendy K. Chung;X. Sharon Wu-Peng;Yiying Zhang

  • Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†

    Tayeba Khan;Eric S. Muise;Puneeth Iyengar;Puneeth Iyengar;Zhao V. Wang

  • Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

    Nina Balthasar;Roberto Coppari;Julie McMinn;Shun M Liu

  • Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

    Tadahiro Kitamura;Yun Feng;Yukari Ido Kitamura;Streamson C Chua

  • The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

    Roberto Coppari;Masumi Ichinose;Masumi Ichinose;Charlotte E. Lee;Abigail E. Pullen

  • Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

    Gina M. Leinninger;Young Hwan Jo;Rebecca L. Leshan;Gwendolyn W. Louis

  • Obesity, metabolic syndrome, and prostate cancer

    Ann W Hsing;Lori C Sakoda;Streamson C Chua

  • Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

    Jennifer W. Hill;Carol F. Elias;Makoto Fukuda;Kevin W. Williams

  • Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse

    Michael P. Wajnrajch;Michael P. Wajnrajch;Joseph M. Gertner;Madeleine D. Harbison;Streamson C. Chua

  • Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.

    Brendan N. Reid;Gene P. Ables;Oleg A. Otlivanchik;Gabriele Schoiswohl

  • Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.

    José Donato Jr.;José Donato Jr.;Roberta Mascioli Cravo;Renata Frazão;Laurent Gautron

  • The molecular genetics of rodent single gene obesities.

    Rudolph L. Leibel;Wendy K. Chung;Streamson C. Chua

  • Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

    Carl De Luca;Timothy J. Kowalski;Yiying Zhang;Joel K. Elmquist

  • Prostate Cancer Risk and Serum Levels of Insulin and Leptin: a Population-Based Study

    Ann W. Hsing;Streamson Chua;Yu Tang Gao;Elisabeth Gentzschein

  • Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

    Streamson C. Chua;David W. White;X. Sharon Wu-Peng;Shun Mei Liu

  • Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

    Esther van de Wall;Rebecca Leshan;Allison W. Xu;Nina Balthasar

  • The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7

    Eric D. Green;Margherita Maffei;Valerie V. Braden;Ricardo Proenca;Ricardo Proenca

  • Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVBdb/db Mice With Type 2 Diabetes

    Zhuowei Wang;Tao Jiang;Jinping Li;Gregory Proctor

  • The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

    Eiichi Hinoi;Nan Gao;Dae Young Jung;Vijay Yadav

  • Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat

    X. Sharon Wu-Peng;Streamson C. Chua;Norichika Okada;Shun Mei Liu

Frequent Co-Authors

Rudolph L. Leibel
Rudolph L. Leibel Columbia University
Gary J. Schwartz
Gary J. Schwartz Albert Einstein College of Medicine
Philipp E. Scherer
Philipp E. Scherer The University of Texas Southwestern Medical Center
Wendy K. Chung
Wendy K. Chung Columbia University
Martin G. Myers
Martin G. Myers University of Toronto
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center
Thomas Ludwig
Thomas Ludwig Columbia University
Herbert B. Tanowitz
Herbert B. Tanowitz Albert Einstein College of Medicine
Ann W. Hsing
Ann W. Hsing Stanford University
Louis A. Tartaglia
Louis A. Tartaglia Toledo Clinic Cancer Center

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