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Molecular Biology

D-Index
75
Citations
20193
World Ranking
1191
National Ranking
30

Overview

Peter W. Gunning is affiliated with the University of New South Wales in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine as well.

Their work focuses on subfields such as Cell Biology, Molecular Biology, Cardiology and Cardiovascular Medicine, Oncology, and Immunology and Allergy.

Key research topics addressed by Peter W. Gunning include:

  • Cellular Mechanics and Interactions
  • Microtubule and mitosis dynamics
  • Cardiomyopathy and Myosin Studies
  • Cellular transport and secretion
  • Cell Adhesion Molecules Research
  • Cancer-related Molecular Pathways
  • RNA Research and Splicing

Peter W. Gunning has co-authored frequently with several researchers including:

  • Edna C. Hardeman
  • Nicole S. Bryce
  • María Lastra Cagigas
  • Nicholas Ariotti
  • James Rae

They have published extensively in a range of scientific venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cytoskeleton
  • Nature Communications
  • Nature Materials
  • Current Biology

Selected recent publications include:

  • Focal adhesions contain three specialized actin nanoscale layers, 2024, Nature Communications
  • Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation, 2021, Nature Materials
  • Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments, 2020, Current Biology
  • Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment, 2020, iScience
  • A robust method for particulate detection of a genetic tag for 3D electron microscopy, 2021, eLife

Best Publications

  • Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

    P Gunning;P Ponte;H Okayama;J Engel

  • Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

    Phyllis Ponte;Sun-Yu Ng;Joanne Engel;Peter Gunning

  • A human beta-actin expression vector system directs high-level accumulation of antisense transcripts

    Peter Gunning;John Leavitt;George Muscat;Sun-Yu Ng

  • Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space

    Peter Gunning;Geraldine O’neill;Edna Hardeman

  • Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

    P Ponte;P Gunning;H Blau;L Kedes

  • Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.

    Sun-Yu Ng;P. Gunning;R. Eddy;P. Ponte

  • Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.

    Daniel MacArthur;Jane T Seto;Jane T Seto;Joanna M Raftery;Kate G Quinlan;Kate G Quinlan

  • Tropomyosin isoforms: divining rods for actin cytoskeleton function.

    Peter W. Gunning;Galina Schevzov;Anthony J. Kee;Edna C. Hardeman

  • The evolution of compositionally and functionally distinct actin filaments

    Peter W. Gunning;Umesh Ghoshdastider;Shane Whitaker;David Popp

  • An Actn3 knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance

    Daniel G. MacArthur;Jane T. Seto;Stephen Chan;Kate G.R. Quinlan

  • A molecular pathway for myosin II recruitment to stress fibers.

    Sari Tojkander;Gergana Gateva;Galina Schevzov;Pirta Hotulainen

  • The actin cytoskeleton as a sensor and mediator of apoptosis.

    Desouza M;Gunning Pw;Stehn

  • Specification of Actin Filament Function and Molecular Composition by Tropomyosin Isoforms

    Nicole S. Bryce;Galina Schevzov;Vicki Ferguson;Justin M. Percival

  • Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells.

    P W Gunning;G E Landreth;M A Bothwell;E M Shooter

  • Tropomyosin – master regulator of actin filament function in the cytoskeleton

    Peter W. Gunning;Edna C. Hardeman;Pekka Lappalainen;Daniel P. Mulvihill

  • Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.

    Lars M. Ittner;Thomas Fath;Yazi D. Ke;Mian Bi

  • Beta and gamma actin mRNAs are differentially located within myoblasts

    Mark A. Hill;Peter Gunning

  • Primary support cultures of hippocampal and substantia nigra neurons

    Thomas Fath;Yazi D Ke;Peter Gunning;Jürgen Götz

  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.

    H P Erba;R Eddy;T Shows;L Kedes

  • 2012 Landes Bioscience. Do not distribute. The actin cytoskeleton as a sensor and mediator of apoptosis

    Melissa Desouza;Peter W. Gunning;Justine R. Stehn

Frequent Co-Authors

Edna C. Hardeman
Edna C. Hardeman University of New South Wales
Larry Kedes
Larry Kedes University of Southern California
Kathryn N. North
Kathryn N. North University of Melbourne
Eric M. Shooter
Eric M. Shooter Stanford University
Wolfgang Weninger
Wolfgang Weninger Medical University of Vienna
Adam McCluskey
Adam McCluskey University of Newcastle Australia
Jim J.-C. Lin
Jim J.-C. Lin University of Iowa
Ian E. Alexander
Ian E. Alexander University of Sydney
Nikolas K. Haass
Nikolas K. Haass University of Queensland
Pekka Lappalainen
Pekka Lappalainen University of Helsinki

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