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Biology and Biochemistry

D-Index
55
Citations
12547
World Ranking
14932
National Ranking
409

Overview

Edna C. Hardeman is affiliated with the University of New South Wales in Australia and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research spans several subfields including Cell Biology, Molecular Biology, Cardiology and Cardiovascular Medicine, Oncology, and Biophysics.

The scientist's research covers topics such as Cellular Mechanics and Interactions, Microtubule and mitosis dynamics, Cardiomyopathy and Myosin Studies, Cellular transport and secretion, Cancer-related Molecular Pathways, Advanced Electron Microscopy Techniques and Applications, and Cell death mechanisms and regulation.

Frequent venues of publication for Edna C. Hardeman include bioRxiv (Cold Spring Harbor Laboratory), Cytoskeleton, Nature Materials, American Journal Of Pathology, and Research Square. These venues collectively account for a significant portion of their published work.

Their recent papers include:

  • Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation, 2021, Nature Materials
  • Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment, 2020, iScience
  • A robust method for particulate detection of a genetic tag for 3D electron microscopy, 2021, eLife
  • Highly efficient platelet generation in lung vasculature reproduced by microfluidics, 2023, Nature Communications
  • Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects, 2020, Molecular Cancer Research

Edna C. Hardeman has collaborated frequently with several researchers including Peter W. Gunning, Nicole S. Bryce, María Lastra Cagigas, Nicholas Ariotti, and James Rae.

Best Publications

  • Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

    Lars M. Ittner;Yazi D. Ke;Fabien Delerue;Mian Bi

  • Plasticity of the differentiated state.

    Helen M. Blau;Grace K. Pavlath;Edna C. Hardeman;Choy-Pik Chiu

  • Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space

    Peter Gunning;Geraldine O’neill;Edna Hardeman

  • Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.

    Daniel MacArthur;Jane T Seto;Jane T Seto;Joanna M Raftery;Kate G Quinlan;Kate G Quinlan

  • Tropomyosin isoforms: divining rods for actin cytoskeleton function.

    Peter W. Gunning;Galina Schevzov;Anthony J. Kee;Edna C. Hardeman

  • An Actn3 knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance

    Daniel G. MacArthur;Jane T. Seto;Stephen Chan;Kate G.R. Quinlan

  • Targeted selection of recombinant clones through gene dosage effects.

    Jasper Rine;William Hansen;Edna Hardeman;Ronald W. Davis

  • Specification of Actin Filament Function and Molecular Composition by Tropomyosin Isoforms

    Nicole S. Bryce;Galina Schevzov;Vicki Ferguson;Justin M. Percival

  • Tropomyosin – master regulator of actin filament function in the cytoskeleton

    Peter W. Gunning;Edna C. Hardeman;Pekka Lappalainen;Daniel P. Mulvihill

  • Transcription occurs in pulses in muscle fibers

    Sarah Newlands;Linda K. Levitt;C. Stephen Robinson;A.B. Carmen Karpf

  • Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice.

    K J Brennan;E C Hardeman

  • A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells

    Justine Stehn;Nikolas K Haass;Nikolas K Haass;Nikolas K Haass;Theresa Bonello;Melissa Desouza

  • C2C12 Co‐culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression

    S.T. Cooper;A.L. Maxwell;E. Kizana;E. Kizana;M. Ghoddusi

  • Nemaline Myopathy Caused by Mutations in the Muscle α-Skeletal-Actin Gene

    Biljana Ilkovski;Sandra T. Cooper;Kristen Nowak;Kristen Nowak;Monique M. Ryan

  • Four and a Half LIM Protein 1 Binds Myosin-binding Protein C and Regulates Myosin Filament Formation and Sarcomere Assembly

    Meagan J. McGrath;Denny L. Cottle;Mai-Anh Nguyen;Jennifer M. Dyson

  • Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts.

    Keith A. Webster;Peter Gunning;Edna Hardeman;Douglas C. Wallace

  • Multiple mechanisms regulate muscle fiber diversity.

    Peter Gunning;Edna Hardeman

  • Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy

    Belinda Simone Cowling;Meagan Jane Mcgrath;Mai-Anh Nguyen;Denny Cottle

  • Differential patterns of transcript accumulation during human myogenesis.

    P Gunning;E Hardeman;R Wade;P Ponte

  • A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells. Supplementary figures.

    Justine R. Stehn;Nikolas K. Haass;Teresa Bonello;Melissa Desouza

Frequent Co-Authors

Peter W. Gunning
Peter W. Gunning University of New South Wales
Kathryn N. North
Kathryn N. North University of Melbourne
Wolfgang Weninger
Wolfgang Weninger Medical University of Vienna
Adam McCluskey
Adam McCluskey University of Newcastle Australia
Robert D. Simoni
Robert D. Simoni Stanford University
Nikolas K. Haass
Nikolas K. Haass University of Queensland
Robert G. Parton
Robert G. Parton University of Queensland
Nigel G. Laing
Nigel G. Laing University of Western Australia
Gregory J. Cooney
Gregory J. Cooney University of Sydney
Daniel G. MacArthur
Daniel G. MacArthur Garvan Institute of Medical Research

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