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D-Index & Metrics

Chemistry

D-Index
46
Citations
6858
World Ranking
16148
National Ranking
4022

Overview

Stefano Costanzi is affiliated with the American University in the United States and has an extensive publication record focused primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work intersects several subfields including Organic Chemistry, Molecular Biology, Physiology, Computational Theory and Mathematics, and Rheumatology.

The research topics addressed by Costanzi emphasize Adenosine and Purinergic Signaling, Computational Drug Discovery Methods, and Receptor Mechanisms and Signaling. Additional areas of study include Chemistry and Chemical Engineering, Monoclonal and Polyclonal Antibodies Research, Neuropeptides and Animal Physiology, and Bacillus and Francisella bacterial research.

Costanzi's recent published papers span diverse but interrelated scientific domains. Notable papers include:

  • Chemical Warfare Agents, 2020, Kirk-Othmer Encyclopedia of Chemical Technology
  • Lists of Chemical Warfare Agents and Precursors from International Nonproliferation Frameworks: Structural Annotation and Chemical Fingerprint Analysis, 2020, Journal of Chemical Information and Modeling
  • GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism, 2023, Journal of Molecular Graphics and Modelling
  • Strengthening controls on Novichoks: a family-based approach to covering A-series agents and precursors under the chemical-weapons nonproliferation regime, 2021, The Nonproliferation Review

The frequent coauthors with whom Costanzi has collaborated include Kenneth A. Jacobson, T. Kendall Harden, Giuseppe Grandaliano, Gregory D. Koblentz, and Gisella Vischini. These collaborations highlight interdisciplinary and cross-institutional research efforts.

Costanzi's papers have been published repeatedly in venues such as UNC Libraries, Annals of the Rheumatic Diseases, Nephrology Dialysis Transplantation, Pure and Applied Chemistry, and the Journal of Chemical Information and Modeling. This distribution reflects a broad engagement with journals covering rheumatology, chemistry, and biomedical informatics.

Overall, Stefano Costanzi's research contributions focus on advancing understanding in molecular signaling pathways, chemical warfare agent analysis, and therapeutic strategies within medicine and chemical sciences. The work demonstrates a blend of experimental, computational, and theoretical approaches across a range of biomedical and chemical disciplines.

Best Publications

  • Adenosine deaminase: Functional implications and different classes of inhibitors

    Gloria Cristalli;Stefano Costanzi;Catia Lambertucci;Giulio Lupidi

  • Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

    Giampaolo Trivellin;Adrian F. Daly;Fabio R. Faucz;Bo Yuan

  • Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

    Mayako Michino;Enrique Abola;Charles L. Brooks;J. Scott Dixon

  • Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006

    Pietro Manuel Ferraro;Stefano Costanzi;Alessandro Naticchia;Antonio Sturniolo

  • Nerve Agents: What They Are, How They Work, How to Counter Them.

    Stefano Costanzi;John-Hanson Machado;Moriah Mitchell

  • On the Applicability of GPCR Homology Models to Computer-Aided Drug Discovery: A Comparison between In Silico and Crystal Structures of the β2-Adrenergic Receptor

    Stefano Costanzi

  • Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

    Jian-kang Jiang;Kamran Ghoreschi;Francesca Deflorian;Zhi Chen

  • Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

    Stefano Costanzi;Liaman Mamedova;Zhan-Guo Gao;Kenneth A. Jacobson

  • Discovery of novel Agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening

    Irina G. Tikhonova;Chi Shing Sum;Susanne Neumann;Stanislav Engel

  • Prediction of passive blood-brain partitioning: straightforward and effective classification models based on in silico derived physicochemical descriptors.

    Santiago Vilar;Mayukh Chakrabarti;Stefano Costanzi

  • Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

    Seungkirl Ahn;Alem W. Kahsai;Biswaranjan Pani;Qin-Ting Wang

  • Identification of Residues Important for Agonist Recognition and Activation in GPR40

    Chi Shing Sum;Irina G. Tikhonova;Susanne Neumann;Stanislav Engel

  • A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

    Holger Jäschke;Holger Jäschke;Susanne Neumann;Susanna Moore;Craig J. Thomas

  • N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.

    Rosaria Volpini;Stefano Costanzi;Catia Lambertucci;Sara Taffi

  • Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.

    Baraldi Pg;Cacciari B;Pineda de Las Infantas Mj;Romagnoli R

  • New substituted 9-alkylpurines as adenosine receptor ligands

    Emidio Camaioni;Stefano Costanzi;Sauro Vittori;Rosaria Volpini

  • A2B adenosine receptor blockade inhibits growth of prostate cancer cells

    Qiang Wei;Stefano Costanzi;Ramachandran Balasubramanian;Zhan-Guo Gao

  • A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.

    Susanne Neumann;Gunnar Kleinau;Stefano Costanzi;Susanna Moore

  • Evaluation of Small Molecule Modulators of the Luteinizing Hormone/Choriogonadotropin and Thyroid Stimulating Hormone Receptors: Structure Activity Relationships and Selective Binding Patterns

    Susanna Moore;Holger Jaeschke;Gunnar Kleinau;Susanne Neumann

  • Human P2Y6 Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference

    Stefano Costanzi;Bhalchandra V. Joshi;Savitri Maddileti;Liaman Mamedova

  • Medicinal chemistry and pharmacology of A2B adenosine receptors.

    Rosaria Volpini;Stefano Costanzi;Sauro Vittori;Gloria Cristalli

  • Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

    Irina G. Tikhonova;Chi Shing Sum;Susanne Neumann;Craig J. Thomas

Frequent Co-Authors

Sauro Vittori
Sauro Vittori University of Camerino
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Karl-Norbert Klotz
Karl-Norbert Klotz University of Würzburg
Marvin C. Gershengorn
Marvin C. Gershengorn National Institutes of Health
Jürgen Wess
Jürgen Wess National Institutes of Health
T. Kendall Harden
T. Kendall Harden University of North Carolina at Chapel Hill
Craig J. Thomas
Craig J. Thomas National Institutes of Health
Zhan-Guo Gao
Zhan-Guo Gao National Institutes of Health
Stanko S. Stojilkovic
Stanko S. Stojilkovic National Institutes of Health
Albert Beckers
Albert Beckers University of Liège

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