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D-Index & Metrics

Chemistry

D-Index
119
Citations
50118
World Ranking
518
National Ranking
224

Biology and Biochemistry

D-Index
123
Citations
52443
World Ranking
559
National Ranking
354

Overview

David A. Wink is affiliated with the National Institutes of Health in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable contributions to subfields including Immunology, Oncology, Cancer Research, Molecular Biology, and Physiology.

The scientist's research focuses on several key topics, such as:

  • Cancer, Hypoxia, and Metabolism
  • Immune cells in cancer
  • Inflammatory mediators and NSAID effects
  • Nitric Oxide and Endothelin Effects
  • Eicosanoids and Hypertension Pharmacology
  • Cancer, Stress, Anesthesia, and Immune Response
  • Cancer Immunotherapy and Biomarkers

David A. Wink has published extensively, with some frequent publication venues including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Research Square (Research Square)
  • British Journal of Cancer

Among their recent papers are:

  • "Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase," 2020, Nature Communications
  • "Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight," 2020, Metabolites
  • "Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model," 2020, British Journal of Cancer
  • "Targeting Nitric Oxide: Say NO to Metastasis," 2022, Clinical Cancer Research
  • "Nitric Oxide and Cancer: When to Give and When to Take Away?", 2021, Inorganic Chemistry

Frequent collaborators include Lisa A. Ridnour, Stephen Lockett, Daniel W. McVicar, Robert Y.S. Cheng, and Veena Somasundaram.

Best Publications

  • A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite.

    Katrina M. Miranda;Michael G. Espey;David A. Wink

  • Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

    David A. Wink;James B. Mitchell

  • DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

    David A. Wink;Kazimierz S. Kasprzak;Chris M. Maragos;Rosalie K. Elespuru

  • The chemical biology of nitric oxide: implications in cellular signaling.

    Douglas D. Thomas;Lisa A. Ridnour;Jeffrey S. Isenberg;Wilmarie Flores-Santana

  • Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species

    David A. Wink;Ingeborg Hanbauer;Murali C. Krishna;William Degraff

  • Complexes of 'NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects

    Chris M. Maragos;Deborah Morley;David A. Wink;Tambra M. Dunams

  • The multifaceted roles of nitric oxide in cancer.

    D A Wink;Y Vodovotz;J Laval;F Laval

  • Nitric oxide and redox mechanisms in the immune response

    David A. Wink;Harry B. Hines;Robert Y. S. Cheng;Christopher H. Switzer

  • Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations

    Margaret M. Tarpey;David A. Wink;Matthew B. Grisham

  • I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation

    Matthew B. Grisham;David Jourd’Heuil;David A. Wink

  • New nitric oxide-releasing zwitterions derived from polyamines

    Joseph A. Hrabie;John R. Klose;David A. Wink;Larry K. Keefer

  • The emerging biology of the nitrite anion

    Mark T Gladwin;Alan N Schechter;Daniel B Kim-Shapiro;Rakesh P Patel

  • "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms

    Larry K. Keefer;Raymond W. Nims;Keith M. Davies;David A. Wink

  • Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

    Mohanraj Rajesh;Partha Mukhopadhyay;Sándor Bátkai;Vivek Patel

  • Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction.

    David A. Wink;John F. Darbyshire;Raymond W. Nims;Joseph E. Saavedra

  • Autoxidation kinetics of aqueous nitric oxide

    Peter C. Ford;David A. Wink;David M. Stanbury

  • Mechanisms of the antioxidant effects of nitric oxide.

    David A. Wink;Katrina M. Miranda;Michael G. Espey;Ryzard M. Pluta

  • Inhibition of Cytochromes P450 by Nitric Oxide and a Nitric Oxide-Releasing Agent

    David A. Wink;Yoichi Osawa;John F. Darbyshire;Collins R. Jones

  • Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

    Allen M. Miles;D. Scott Bohle;D. Scott Bohle;Peter A. Glassbrenner;Peter A. Glassbrenner;Bernhard Hansert;Bernhard Hansert

  • The reduction potential of nitric oxide (NO) and its importance to NO biochemistry

    Michael D. Bartberger;Wei Liu;Eleonora Ford;Katrina M. Miranda

  • Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.

    Lorne J. Hofseth;Shin'ichi Saito;S. Perwez Hussain;Michael G. Espey

Frequent Co-Authors

Katrina M. Miranda
Katrina M. Miranda University of Arizona
David D. Roberts
David D. Roberts National Institutes of Health
James B. Mitchell
James B. Mitchell National Institutes of Health
Matthew B. Grisham
Matthew B. Grisham Texas Tech University Health Sciences Center
John A. Cook
John A. Cook National Institutes of Health
Jon M. Fukuto
Jon M. Fukuto Sonoma State University
William DeGraff
William DeGraff National Institutes of Health
Martin Feelisch
Martin Feelisch University of Southampton
Yoram Vodovotz
Yoram Vodovotz University of Pittsburgh
Peter C. Ford
Peter C. Ford University of California, Santa Barbara

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