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Frank J. Giordano

Frank J. Giordano

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
16381
World Ranking
17833
National Ranking
7298

Overview

Frank J. Giordano is affiliated with Yale University in the United States and conducts research primarily within the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Cancer Research, Oncology, Immunology, and Cell Biology.

The main research topics covered by Frank J. Giordano include:

  • Microbial metabolism and enzyme function
  • Cancer, Hypoxia, and Metabolism
  • Protein Tyrosine Phosphatases
  • Peptidase Inhibition and Analysis
  • Galectins and Cancer Biology
  • Aldose Reductase and Taurine
  • Hormonal Regulation and Hypertension

Their recent papers reflect a focus on cardiovascular and molecular biology research with notable publications such as:

  • Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines, 2021, Cardiovascular Drugs and Therapy
  • Abstract 16205: MKP-5 Deficiency Attenuates Pressure Overload-induced Cardiac Hypertrophy, 2020, Circulation
  • Renalase activates mitochondrial leak metabolism in response to cellular stress and to repair damage after injury, 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • Cover Image, Volume 58, Issue 3-4, 2020, genesis
  • Abstract 13764: Renalase Peptide Agonist Therapy Normalizes the Cardiac Response to Pressure Overload in Chronic Kidney Disease, 2022, Circulation

Frank J. Giordano frequently publishes in venues such as:

  • Circulation
  • Cardiovascular Drugs and Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • genesis
  • SSRN Electronic Journal

The scientist collaborates recurrently with several researchers, including:

  • Fred S. Gorelick
  • Robert Safirstein
  • Gary V. Désir
  • Anton M. Bennett
  • Xiaojia Guo

Best Publications

  • Oxygen, oxidative stress, hypoxia, and heart failure

    Frank J. Giordano

  • The VIVA Trial Vascular Endothelial Growth Factor in Ischemia for Vascular Angiogenesis

    Timothy D. Henry;Brian H. Annex;George R. McKendall;Michael A. Azrin

  • Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury

    J. Dawn Abbott;Yan Huang;Dingang Liu;Reed Hickey

  • AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

    Raymond R. Russell;Ji Li;David L. Coven;Marc Pypaert

  • Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis

    Nan Tang;Lianchun Wang;Jeffrey Esko;Frank J. Giordano

  • Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart.

    Giordano Fj;Ping P;McKirnan;Nozaki S

  • Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion: evidence for a dose-dependent effect.

    Robert C. Hendel;Timothy D. Henry;Krishna Rocha-Singh;Jeffrey M. Isner

  • The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

    Claus Hellerbrand;Branko Stefanovic;Branko Stefanovic;Branko Stefanovic;Frank Giordano;Frank Giordano;Frank Giordano;Elmar R Burchardt;Elmar R Burchardt;Elmar R Burchardt

  • A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

    Frank J. Giordano;Hans-Peter Gerber;Simon-Peter Williams;Nicholas VanBruggen

  • Induction of angiogenesis in a mouse model using engineered transcription factors.

    Edward J. Rebar;Yan Huang;Reed Hickey;Anjali K. Nath

  • Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation

    H He;F J Giordano;R Hilal-Dandan;D J Choi

  • Cell Communications in the Heart

    Daniela Tirziu;Frank J. Giordano;Michael Simons

  • Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction

    David F. Meoli;Mehran M. Sadeghi;Svetlana Krassilnikova;Brian N. Bourke

  • Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.

    Valia T. Mihaylova;Ranjit S. Bindra;Jianling Yuan;Denise Campisi

  • Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

    Jeremy Grunstein;Joseph J. Masbad;Reed Hickey;Frank Giordano

  • Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease

    Timothy D. Henry;Krishna Rocha-Singh;Jeffrey M. Isner;Dean J. Kereiakes

  • Cardiac myocyte-specific HIF-1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

    Yan Huang;Reed P. Hickey;Jennifer L. Yeh;Dinggang Liu

  • VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis

    Anthony A. Lanahan;Karlien Hermans;Filip Claes;Joanna S. Kerley-Hamilton

  • Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice

    Takahisa Murata;Michelle I. Lin;Yan Huang;Jun Yu

  • Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance

    Steven D Mason;Richard A Howlett;Matthew J Kim;I. Mark Olfert

Frequent Co-Authors

William C. Sessa
William C. Sessa Pfizer (United States)
Randall S. Johnson
Randall S. Johnson University of Cambridge
Jun Yu
Jun Yu Chinese University of Hong Kong
Wolfgang H. Dillmann
Wolfgang H. Dillmann University of California, San Diego
Michael Simons
Michael Simons Yale University
Edward J. Rebar
Edward J. Rebar Sangamo BioSciences (United States)
Barbara E. Ehrlich
Barbara E. Ehrlich Yale University
Wang Min
Wang Min Yale University
Kenneth R. Chien
Kenneth R. Chien Karolinska Institute
Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)

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