World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
48
Citations
9087
World Ranking
15167
National Ranking
3852

Overview

Jack A. Hinson is affiliated with the University of Arkansas for Medical Sciences in the United States. Their research focuses on several fields including Computational Theory and Mathematics, Pharmacology, Molecular Biology, Physiology, and Pharmaceutical Science. These areas contribute to a broad understanding of drug discovery and metabolism.

The scientist's recent publications span various topics and include:

  • The development and hepatotoxicity of acetaminophen: reviewing over a century of progress (2020), published in Drug Metabolism Reviews
  • Advances in biomarker development in acetaminophen toxicity (2020), published in Advances in clinical chemistry
  • Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report) (2021), published in Pure and Applied Chemistry
  • 191 Reactive Intermediates (2022), published in IUPAC Standards Online
  • 20 Aromatic Hydrocarbon Receptor (Ahr) (2022), published in IUPAC Standards Online

They have coauthored extensively with several researchers, including Paul Erhardt, Kenneth Bachmann, Donald Birkett, Michael Boberg, and Nicholas Bodor.

The most frequent publication venues associated with Jack A. Hinson are:

  • IUPAC Standards Online with 241 publications
  • Drug Metabolism Reviews
  • Advances in clinical chemistry
  • Pure and Applied Chemistry

Their primary research topics cover:

  • Computational Drug Discovery Methods
  • Pharmacogenetics and Drug Metabolism
  • Chemical Reactions and Isotopes
  • Diet and metabolism studies
  • Metabolism and Genetic Disorders
  • Cancer, Hypoxia, and Metabolism
  • Amino Acid Enzymes and Metabolism

Best Publications

  • Mechanisms of Hepatotoxicity

    Hartmut Jaeschke;Gregory J. Gores;Arthur I. Cederbaum;Jack A. Hinson

  • ACETAMINOPHEN-INDUCED HEPATOTOXICITY

    Laura P. James;Philip R. Mayeux;Jack A. Hinson

  • Selective Protein Covalent Binding and Target Organ Toxicity

    Steven D. Cohen;Neil R. Pumford;Edward A. Khairallah;Kim Boekelheide

  • Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes

    Angela B. Reid;Richard C. Kurten;Sandra S. McCullough;Robert W. Brock

  • Vascular and Hepatocellular Peroxynitrite Formation during Acetaminophen Toxicity: Role of Mitochondrial Oxidant Stress

    Tamara R. Knight;Angela Kurtz;Mary Lynn Bajt;Jack A. Hinson

  • Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species.

    Sherryll L. Michael;Neil R. Pumford;Philip R. Mayeux;Michael R. Niesman

  • Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition

    Jack A. Hinson;Angela B. Reid;Sandra S. McCullough;Laura P. James

  • Measurement of Serum Acetaminophen–Protein Adducts in Patients With Acute Liver Failure

    Timothy J. Davern;Laura P. James;Jack A. Hinson;Julie Polson

  • Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.

    Jack A. Hinson;Sherryll L. Pike;Neil R. Pumford;Philip R. Mayeux

  • Effect of N-Acetylcysteine on Acetaminophen Toxicity in Mice: Relationship to Reactive Nitrogen and Cytokine Formation

    Laura P. James;Sandra S. McCullough;Laura W. Lamps;Jack A. Hinson

  • DETERMINATION OF ACETAMINOPHEN-PROTEIN ADDUCTS IN MOUSE LIVER AND SERUM AND HUMAN SERUM AFTER HEPATOTOXIC DOSES OF ACETAMINOPHEN USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

    Kenneth L. Muldrew;Laura P. James;Leslie Coop;Sandra S. McCullough

  • Acetaminophen-induced hepatotoxicity.

    Jack A. Hinson;Lance R. Pohl;Terrence J. Monks;James R. Gillette

  • Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

    Laura P James;Lynda G Letzig;Pippa M Simpson;Edmund Capparelli

  • Immunochemical detection of oxidized proteins.

    Keller Rj;Halmes Nc;Hinson Ja;Pumford Nr

  • NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia

    Jaspreet S. Gujral;Jack A. Hinson;Anwar Farhood;Hartmut Jaeschke

  • Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress.

    Jennifer D. Gibson;Neil R. Pumford;Victor M. Samokyszyn;Jack A. Hinson

  • 3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

    J A Hinson;T J Monks;M Hong;R J Highet

  • In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa.

    Jun Gu;Huadong Cui;Melissa Behr;Li Zhang

  • Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice.

    Jack A. Hinson;Thomas J. Bucci;Lisa K. Irwin;Sherryll L. Michael

  • Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

    Gerard J. Mulder;Jack A. Hinson;James R. Gillette

  • Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.

    Jack A. Hinson;Neil R. Pumford;Dean W. Roberts

  • A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein.

    Neil R. Pumford;Brian M. Martin;Jack A. Hinson

  • Covalent Binding of Xenobiotics to Specific Proteins in the Liver

    N. R. Pumford;N. C. Halmes;J. A. Hinson

  • Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.

    Joseph H. Holthoff;Kellie A. Woodling;Daniel R. Doerge;Samuel T. Burns

Frequent Co-Authors

James R. Gillette
James R. Gillette National Institutes of Health
Pippa Simpson
Pippa Simpson Medical College of Wisconsin
Lance R. Pohl
Lance R. Pohl National Institutes of Health
Gregory L. Kearns
Gregory L. Kearns University of Arkansas for Medical Sciences
Hartmut Jaeschke
Hartmut Jaeschke University of Kansas
William M. Lee
William M. Lee The University of Texas Southwestern Medical Center
Stepan Melnyk
Stepan Melnyk University of Arkansas for Medical Sciences
Robert J. Fontana
Robert J. Fontana University of Michigan–Ann Arbor
Xinxin Ding
Xinxin Ding University of Arizona
Daniel A. Casciano
Daniel A. Casciano University of Arkansas at Little Rock

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students exploring Chemistry in the USA, numerous career pathways and related online degrees can complement their studies. An paralegal studies associate degree, for instance, offers a foundation in legal aspects of scientific research and patent law, which can be valuable for chemists interested in intellectual property.

Those inclined toward the business side might consider how to become a pharmaceutical sales rep, a role that blends chemistry knowledge with strong communication skills. Understanding how to become a pharmaceutical sales rep can open doors to lucrative positions within the healthcare and pharmaceutical industries.

For more clinically focused chemistry careers, learning how long does it take to become a pharmacist is crucial. Pharmacists play an essential role in medicine management, relying heavily on chemistry expertise to ensure patient safety and efficacy of drugs.

Additionally, individuals interested in forensic science can explore educational requirements and job prospects by looking at the autopsy tech salary and related career outlooks. This path combines chemistry with hands-on investigative work to help solve crimes.

Best Scientists Citing Jack A. Hinson

Trending Scientists

Recently Published Articles