D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 58 Citations 9,354 149 World Ranking 9067 National Ranking 4052

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Biochemistry, Pharmacology, Microsome, Metabolite and Acetaminophen are his primary areas of study. His Biochemistry research incorporates themes from Molecular biology, Halothane and Drug. His work carried out in the field of Pharmacology brings together such families of science as Gene expression profiling, Toxicity and Halothane hepatitis.

His studies in Microsome integrate themes in fields like Cytochrome, Antibody, Cysteine and Stereochemistry. His Metabolite research includes themes of Chromatography, Chloroform and Phosgene. In his study, Cytotoxic T cell is inextricably linked to Immunology, which falls within the broad field of Liver injury.

His most cited work include:

  • Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. (269 citations)
  • Selective Protein Covalent Binding and Target Organ Toxicity (259 citations)
  • Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. (245 citations)

What are the main themes of his work throughout his whole career to date?

Lance R. Pohl mainly focuses on Biochemistry, Microsome, Immunology, Pharmacology and Metabolite. Lance R. Pohl has researched Biochemistry in several fields, including Chromatography, Halothane and In vivo. The study incorporates disciplines such as Isoflurane, Internal medicine, Hepatitis and Antibody, Hapten in addition to Halothane.

His Microsome study integrates concerns from other disciplines, such as Hydroxylation, Cytochrome, Stereochemistry and Metabolism. He works mostly in the field of Immunology, limiting it down to concerns involving Liver injury and, occasionally, Acetaminophen. The Pharmacology study combines topics in areas such as Enflurane and Toxicity.

He most often published in these fields:

  • Biochemistry (40.91%)
  • Microsome (26.62%)
  • Immunology (18.18%)

What were the highlights of his more recent work (between 1997-2017)?

  • Immunology (18.18%)
  • Liver injury (12.34%)
  • Acetaminophen (13.64%)

In recent papers he was focusing on the following fields of study:

Immunology, Liver injury, Acetaminophen, Pharmacology and Toxicity are his primary areas of study. As part of one scientific family, Lance R. Pohl deals mainly with the area of Immunology, narrowing it down to issues related to the Drug, and often Immune system, Antigen and Function. His Liver injury research includes elements of Acquired immune system, Eosinophilia and Antibody.

His work deals with themes such as Cell culture, Halothane, Natural killer cell and Hepatitis, which intersect with Pharmacology. His Toxicity research is multidisciplinary, relying on both Heat shock protein, Toxicogenomics and Metabolite. The concepts of his Glutathione study are interwoven with issues in Microsome, Stereochemistry and Metabolism.

Between 1997 and 2017, his most popular works were:

  • Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. (269 citations)
  • Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. (245 citations)
  • Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac. (152 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

His main research concerns Liver injury, Acetaminophen, Pharmacology, Immunology and Interleukin. His research in Liver injury intersects with topics in ALDH2, Acetylation and Toxicogenomics. His studies deal with areas such as Metabolite, Enzyme, Hepatitis and Heat shock protein as well as Acetaminophen.

His Pharmacology research incorporates elements of Transcription factor, Gene expression, Gene expression profiling and Toxicity. His study in Immunology is interdisciplinary in nature, drawing from both Confounding, Cytotoxic T cell and Drug. His Interleukin study combines topics from a wide range of disciplines, such as Proteome, Cell growth, Drug development and Liver disease, Drug-induced liver disease.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.

Changqing Ju;Timothy P. Reilly;Mohammed Bourdi;Michael F. Radonovich.
Chemical Research in Toxicology (2002)

431 Citations

Selective Protein Covalent Binding and Target Organ Toxicity

Steven D. Cohen;Neil R. Pumford;Edward A. Khairallah;Kim Boekelheide.
Toxicology and Applied Pharmacology (1997)

390 Citations

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase.

Mohammed Bourdi;Yasuhiro Masubuchi;Timothy P. Reilly;Hamid R. Amouzadeh.
Hepatology (2002)

367 Citations

Phosgene: a metabolite of chloroform.

Lance R. Pohl;B. Bhooshan;Noel F. Whittaker;Gopal Krishna.
Biochemical and Biophysical Research Communications (1977)

291 Citations

Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.

J G Kenna;H Satoh;D D Christ;L R Pohl.
Journal of Pharmacology and Experimental Therapeutics (1988)

277 Citations

The Immunologic and Metabolic Basis of Drug Hypersensitivities

L R Pohl;H Satoh;D D Christ;J G Kenna.
Annual Review of Pharmacology and Toxicology (1988)

254 Citations

Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.

Sijiu Shen;Michael R. Marchick;Margaret R. Davis;George A. Doss.
Chemical Research in Toxicology (1999)

221 Citations

Acetaminophen-induced hepatotoxicity.

Jack A. Hinson;Lance R. Pohl;Terrence J. Monks;James R. Gillette.
Life Sciences (1981)

217 Citations

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis

Mohammed Bourdi;Weiqiao Chen;Raimund M. Peter;Jackie L. Martin.
Chemical Research in Toxicology (1996)

214 Citations

Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase

H Satoh;B M Martin;A H Schulick;D D Christ.
Proceedings of the National Academy of Sciences of the United States of America (1989)

184 Citations

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