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Chemistry

D-Index
75
Citations
19342
World Ranking
4452
National Ranking
1408

Research.com Recognitions

  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Sidney D. Nelson was affiliated with the University of Washington in the United States. Their academic career included contributions recognized by the American Association for the Advancement of Science (AAAS), having been named a Fellow in 1986.

Throughout their career, Sidney D. Nelson's research and scholarly activities spanned a variety of scientific inquiries. Although specific papers, co-authors, and publication venues are not documented here, their affiliation with a major research institution suggests participation in collaborative and interdisciplinary research efforts.

Their profile does not include detailed information about particular fields or subfields of study, nor main topics of work. There is also no data available concerning book publications from this researcher.

Sidney D. Nelson is recorded as deceased. The information about their work and achievements is presented in the past tense to reflect this status.

Best Publications

  • N-acetyl-p- benzoquinone imine a cytochrome P-450 mediated oxidation product of acetaminophen

    David C. Dahlin;Gerald T. Miwa;Anthony Y. H. Lu;Sidney D. Nelson

  • Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis

    Jerry R. Mitchell;Hyman J. Zimmerman;Kamal G. Ishak;Unnur P. Thorgeirsson

  • Molecular mechanisms of the hepatotoxicity caused by acetaminophen.

    Sidney D. Nelson

  • The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

    M Moore;H Thor;G Moore;S Nelson

  • Managing the challenge of chemically reactive metabolites in drug development

    B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring

  • Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

    E Albano;M Rundgren;P J Harvison;S D Nelson

  • Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.

    Kenneth E. Thummel;Caroline A. Lee;Kent L. Kunze;Sidney D. Nelson

  • Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver

    M A Tirmenstein;S D Nelson

  • Pennyroyal Toxicity: Measurement of Toxic Metabolite Levels in Two Cases and Review of the Literature

    Ilene B. Anderson;Walter H. Mullen;James E. Meeker;Siamak C. Khojasteh-Bakht

  • Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6

    Weiqiao Chen;Luke L. Koenigs;Stella J. Thompson;Raimund M. Peter

  • Metabolic activation and drug toxicity

    Sidney D. Nelson

  • The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study.

    B. Coles;I. Wilson;P. Wardman;J.A. Hinson

  • SYNTHESIS, DECOMPOSITION KINETICS, AND PRELIMINARY TOXICOLOGICAL STUDIES OF PURE N-ACETYL-P-BENZOQUINONE IMINE, A PROPOSED TOXIC METABOLITE OF ACETAMINOPHEN

    D. C. Dahlin;S. D. Nelson

  • Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.

    Sidney D. Nelson

  • The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.

    Sidney D. Nelson;William F. Trager

  • Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals

    Sidney D. Nelson;Paul G. Pearson

  • Molecular Basis for Several Drug-Induced Nephropathies

    Jerry R. Mitchell;Randolph J. McMurtry;Charles N. Statham;Sidney D. Nelson

  • Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis

    Mohammed Bourdi;Weiqiao Chen;Raimund M. Peter;Jackie L. Martin

  • Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides.

    M A Tirmenstein;S D Nelson

  • The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro

    A.J. Streeter;D.C. Dahlin;S.D. Nelson;T.A. Baillie

Frequent Co-Authors

Jørn A. Holme
Jørn A. Holme Norwegian Institute of Public Health
Kenneth E. Thummel
Kenneth E. Thummel University of Washington
William F. Trager
William F. Trager University of Washington
Gunnar Brunborg
Gunnar Brunborg Norwegian Institute of Public Health
David R. Goodlett
David R. Goodlett University of Victoria
Nelson Fausto
Nelson Fausto University of Washington
Terrance J. Kavanagh
Terrance J. Kavanagh University of Washington
Peter Moldéus
Peter Moldéus Karolinska Institute
Lance R. Pohl
Lance R. Pohl National Institutes of Health
Thomas A. Baillie
Thomas A. Baillie University of Washington

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