1986 - Fellow of the American Association for the Advancement of Science (AAAS)
Sidney D. Nelson mainly focuses on Acetaminophen, Metabolite, Biochemistry, Pharmacology and Glutathione. His work carried out in the field of Acetaminophen brings together such families of science as Ethanol, Drug alcohol interaction, Antipyretic, Cytochrome P450 and Mitochondrion. His Metabolite research incorporates elements of Liver injury, Macromolecule, Benzoquinone, Stereochemistry and Cytochrome.
His research integrates issues of Covalent bond and Toxicity in his study of Biochemistry. His study on Pharmacokinetics is often connected to Text mining as part of broader study in Pharmacology. His Glutathione study combines topics from a wide range of disciplines, such as Oxidative phosphorylation, Sulfate conjugate, Hydrogen peroxide and Bovine serum albumin.
His primary areas of study are Biochemistry, Metabolite, Glutathione, Acetaminophen and Stereochemistry. Many of his studies involve connections with topics such as Toxicity and Biochemistry. Sidney D. Nelson merges many fields, such as Metabolite and Menthofuran, in his writings.
As part of one scientific family, Sidney D. Nelson deals mainly with the area of Glutathione, narrowing it down to issues related to the 1,2-Dibromo-3-chloropropane, and often DNA damage. His work is dedicated to discovering how Acetaminophen, NAPQI are connected with Benzoquinone and other disciplines. His biological study spans a wide range of topics, including Adduct, Kinetic isotope effect and Active site.
His primary areas of investigation include Biochemistry, Stereochemistry, Glutathione, Pharmacology and Metabolite. His studies in Stereochemistry integrate themes in fields like Cytochrome, Molecule, Cooperativity and Kinetic isotope effect. His Glutathione study combines topics in areas such as Microsome, Acetaminophen, Cytochrome P450 reductase and Heme.
His Acetaminophen research is multidisciplinary, relying on both Protein kinase A, Phosphorylation, Liver injury, NAPQI and Molecular biology. He interconnects Gene expression, CYP3A4, Viability assay, Toxicity and CYP3A in the investigation of issues within Pharmacology. His research investigates the connection with Metabolite and areas like Adduct which intersect with concerns in Structural isomer, Hepatotoxin and Thiophene.
The scientist’s investigation covers issues in Metabolite, Stereochemistry, Pharmacology, Cytochrome P450 and Glutathione. His research on Metabolite frequently links to adjacent areas such as Adduct. His study in Stereochemistry is interdisciplinary in nature, drawing from both Cooperativity, Hydroxylation, Residue, Cytochrome and Peptide.
The study incorporates disciplines such as Oxidative phosphorylation, Programmed cell death, Hepatocyte, Viability assay and Mitochondrion in addition to Pharmacology. His Cytochrome P450 study improves the overall literature in Biochemistry. His Glutathione study combines topics from a wide range of disciplines, such as Microsome and Heme.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
N-acetyl-p- benzoquinone imine a cytochrome P-450 mediated oxidation product of acetaminophen
David C. Dahlin;Gerald T. Miwa;Anthony Y. H. Lu;Sidney D. Nelson.
Proceedings of the National Academy of Sciences of the United States of America (1984)
Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis
Jerry R. Mitchell;Hyman J. Zimmerman;Kamal G. Ishak;Unnur P. Thorgeirsson.
Annals of Internal Medicine (1976)
Molecular mechanisms of the hepatotoxicity caused by acetaminophen.
Sidney D. Nelson.
Seminars in Liver Disease (1990)
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
M Moore;H Thor;G Moore;S Nelson.
Journal of Biological Chemistry (1985)
Managing the challenge of chemically reactive metabolites in drug development
B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring.
Nature Reviews Drug Discovery (2011)
Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.
E Albano;M Rundgren;P J Harvison;S D Nelson.
Molecular Pharmacology (1985)
Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.
Kenneth E. Thummel;Caroline A. Lee;Kent L. Kunze;Sidney D. Nelson.
Biochemical Pharmacology (1993)
Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver
M A Tirmenstein;S D Nelson.
Journal of Biological Chemistry (1989)
Pennyroyal Toxicity: Measurement of Toxic Metabolite Levels in Two Cases and Review of the Literature
Ilene B. Anderson;Walter H. Mullen;James E. Meeker;Siamak C. Khojasteh-Bakht.
Annals of Internal Medicine (1996)
Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6
Weiqiao Chen;Luke L. Koenigs;Stella J. Thompson;Raimund M. Peter.
Chemical Research in Toxicology (1998)
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