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Chemistry

D-Index
74
Citations
20227
World Ranking
4665
National Ranking
1471

Research.com Recognitions

  • 2011 - Fellow of the American Chemical Society

Overview

Thomas A. Baillie is affiliated with the University of Washington in the United States. Their research spans several fields with a primary focus on pharmacology, toxicology, and pharmaceutics, contributing to a total of seven publications in these areas. They have also engaged in work related to medicine, with six publications in this discipline.

The subfields of study Thomas A. Baillie is involved in include pharmacology, molecular biology, organic chemistry, genetics, and endocrinology, diabetes, and metabolism. Specific research topics cover pharmacogenetics and drug metabolism, click chemistry and applications, chemical reactions and isotopes, ion channel regulation and function, monoclonal and polyclonal antibodies research, chronic lymphocytic leukemia research, and chemical synthesis and analysis.

Frequent publication venues for Baillie's work include:

  • Medicinal Chemistry Research
  • Clinical and Translational Science
  • Expert Opinion on Drug Discovery
  • Drug Metabolism and Disposition

Notable recent research papers authored or co-authored by Thomas A. Baillie include:

  • "Approaches to mitigate the risk of serious adverse reactions in covalent drug design," 2020, Expert Opinion on Drug Discovery
  • "Drug-protein adducts: past, present, and future," 2020, Medicinal Chemistry Research
  • "Acyl glucuronides-mediators of drug-induced toxicities?," 2023, Medicinal Chemistry Research

Other contributions in which Baillie collaborated include:

  • "Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers," 2020, Clinical and Translational Science (co-authored with Frank Schneider)
  • "Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment," 2023, Drug Metabolism and Disposition (co-authored with William L. Fitch)

Thomas A. Baillie has frequently collaborated with researchers including William L. Fitch, Frank Schneider, Margaret Bradbury, David Stamler, and Edward T. Hellriegel.

They were recognized as a Fellow of the American Chemical Society in 2011.

Best Publications

  • The resurgence of covalent drugs

    Juswinder Singh;Russell C. Petter;Thomas A. Baillie;Adrian Whitty

  • Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

    Antonia F. Stepan;Daniel P. Walker;Daniel P. Walker;Jonathan Bauman;Jonathan Bauman;David A. Price;David A. Price

  • Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

    David C. Evans;Alan P. Watt;Deborah A. Nicoll-Griffith;Thomas A. Baillie

  • Targeted covalent inhibitors for drug design

    Thomas Baillie

  • Managing the challenge of chemically reactive metabolites in drug development

    B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring

  • Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?

    Jiunn H. Lin;Masato Chiba;Thomas A. Baillie

  • Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

    Kelem Kassahun;Paul G. Pearson;Wei Tang;Ian McIntosh

  • Glucuronidation of Statins in Animals and Humans: A Novel Mechanism of Statin Lactonization

    Thomayant Prueksaritanont;Raju Subramanian;Xiaojun Fang;Bennett Ma

  • The use of stable isotopes in pharmacological research.

    T A Baillie

  • Drug metabolites in safety testing

    Thomas A. Baillie;Mitchell N. Cayen;Hassan Fouda;Ronald J. Gerson

  • Mass spectrometry in the analysis of glutathione conjugates

    Thomas A. Baillie;Margaret R. Davis

  • Mechanistic studies on metabolic interactions between gemfibrozil and statins.

    Thomayant Prueksaritanont;Jamie J. Zhao;Bennett Ma;Brad A. Roadcap

  • Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid

    Allan E. Rettie;Albert W. Rettenmeier;William N. Howald;Thomas A. Baillie

  • Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism

    Thomas A. Baillie

  • Negative ion tandem mass spectrometry for the detection of glutathione conjugates.

    Christine M. Dieckhaus;Carmen L. Fernández-Metzler;Richard King;Paul H. Krolikowski

  • Biotransformation of the Naturally Occurring Isothiocyanate Sulforaphane in the Rat: Identification of Phase I Metabolites and Glutathione Conjugates

    Kelem Kassahun;Margaret Davis;Pei Hu;Bryan Martin

  • Synthesis and applications of isotopically labelled compounds

    Thomas A. Baillie

  • Studies on Cytochrome P-450-Mediated Bioactivation of Diclofenac in Rats and in Human Hepatocytes: Identification of Glutathione Conjugated Metabolites

    Wei Tang;Ralph A. Stearns;Stelvio M. Bandiera;Yong Zhang

  • Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology.

    Thomas A. Baillie

  • The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro

    A.J. Streeter;D.C. Dahlin;S.D. Nelson;T.A. Baillie

Frequent Co-Authors

Byron H. Arison
Byron H. Arison MSD (United States)
Allan E. Rettie
Allan E. Rettie University of Washington
Sidney D. Nelson
Sidney D. Nelson University of Washington
Neal Castagnoli
Neal Castagnoli Virginia Tech
Evan D. Kharasch
Evan D. Kharasch Duke University
R. Scott Obach
R. Scott Obach Pfizer (United States)
Paul R. Ortiz de Montellano
Paul R. Ortiz de Montellano University of California, San Francisco
B. Kevin Park
B. Kevin Park University of Liverpool
Dean J. Naisbitt
Dean J. Naisbitt University of Liverpool
Kenneth E. Thummel
Kenneth E. Thummel University of Washington

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