2011 - Fellow of the American Chemical Society
His main research concerns Metabolite, Biochemistry, Glutathione, Pharmacology and Stereochemistry. His Metabolite study combines topics in areas such as Microsome, Chromatography and Tandem mass spectrometry. His research on Biochemistry often connects related areas such as In vivo.
The concepts of his Glutathione study are interwoven with issues in Adduct, Troglitazone, Quinone methide and Mass spectrometry. His research integrates issues of Glucuronidation and Drug discovery in his study of Pharmacology. Thomas A. Baillie has researched Stereochemistry in several fields, including Cytochrome, Metabolism, Binding site and Active site.
Thomas A. Baillie mostly deals with Biochemistry, Metabolite, Stereochemistry, Metabolism and Pharmacology. His research investigates the connection between Biochemistry and topics such as In vivo that intersect with problems in In vitro. His study focuses on the intersection of Metabolite and fields such as Chromatography with connections in the field of Ion.
His work on Enantiomer as part of his general Stereochemistry study is frequently connected to Reactive intermediate, thereby bridging the divide between different branches of science. Thomas A. Baillie combines subjects such as Fatty acid and Hydroxylation with his study of Metabolism. His Drug metabolism research is multidisciplinary, incorporating elements of Pharmaceutical industry and Drug discovery.
Thomas A. Baillie mainly focuses on Drug discovery, Drug, Pharmacology, Drug metabolism and Computational biology. The Drug discovery study combines topics in areas such as Covalent binding, Risk analysis, Liquid chromatography–mass spectrometry and Protein mass spectrometry. In general Drug, his work in Drug toxicity is often linked to Animal species linking many areas of study.
His studies deal with areas such as Microsome, Toxicity and Hydroxylation as well as Pharmacology. He usually deals with Microsome and limits it to topics linked to Nitroso and Metabolite. His Metabolite research incorporates elements of Chromatography and Tandem mass spectrometry.
Thomas A. Baillie mainly investigates Drug discovery, Pharmacology, Drug, Drug metabolism and Pharmaceutical industry. His Drug discovery research includes themes of Tandem mass spectrometry, Liquid chromatography–mass spectrometry and First line. His specific area of interest is Pharmacology, where Thomas A. Baillie studies Drug recall.
His work carried out in the field of Drug brings together such families of science as Covalent bond and Toxicity. His Drug metabolism research includes elements of Pharmacokinetics, Biotransformation and Preclinical toxicity. His studies in Pharmaceutical industry integrate themes in fields like Drug induced toxicity, Adverse effect and Pharmacogenomics.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
The resurgence of covalent drugs
Juswinder Singh;Russell C. Petter;Thomas A. Baillie;Adrian Whitty.
Nature Reviews Drug Discovery (2011)
Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
David C. Evans;Alan P. Watt;Deborah A. Nicoll-Griffith;Thomas A. Baillie.
Chemical Research in Toxicology (2004)
Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
Antonia F. Stepan;Daniel P. Walker;Daniel P. Walker;Jonathan Bauman;Jonathan Bauman;David A. Price;David A. Price.
Chemical Research in Toxicology (2011)
Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?
Jiunn H. Lin;Masato Chiba;Thomas A. Baillie.
Pharmacological Reviews (1999)
Managing the challenge of chemically reactive metabolites in drug development
B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring.
Nature Reviews Drug Discovery (2011)
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Kelem Kassahun;Paul G. Pearson;Wei Tang;Ian McIntosh.
Chemical Research in Toxicology (2001)
The use of stable isotopes in pharmacological research.
T A Baillie.
Pharmacological Reviews (1981)
Glucuronidation of Statins in Animals and Humans: A Novel Mechanism of Statin Lactonization
Thomayant Prueksaritanont;Raju Subramanian;Xiaojun Fang;Bennett Ma.
Drug Metabolism and Disposition (2002)
Drug metabolites in safety testing
Thomas A. Baillie;Mitchell N. Cayen;Hassan Fouda;Ronald J. Gerson.
Toxicology and Applied Pharmacology (2002)
Mass spectrometry in the analysis of glutathione conjugates
Thomas A. Baillie;Margaret R. Davis.
Journal of Mass Spectrometry (1993)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: