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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
16414
World Ranking
10654
National Ranking
4631

Overview

Ruin Moaddel is a researcher affiliated with the National Institutes of Health in the United States. Their work spans primarily the fields of medicine and biochemistry, genetics, and molecular biology, with significant contributions in related subfields such as physiology, molecular biology, pharmacology, biological psychiatry, and cellular and molecular neuroscience.

Their research topics focus on areas that include the treatment of major depression, tryptophan and brain disorders, diet and metabolism studies, mitochondrial function and pathology, metabolomics and mass spectrometry studies, adipose tissue and metabolism, as well as neuroscience and neuropharmacology research.

Among their recent publications are:

  • Proteomics in aging research: A roadmap to clinical, translational research (2021, Aging Cell)

They have collaborated frequently with several co-authors, including Luigi Ferrucci, Todd D. Gould, Jacqueline Lovett, Julián Candia, and Toshiko Tanaka. These collaborations reflect ongoing partnerships within interdisciplinary contexts relevant to their main research topics and fields.

Moaddel's work has been published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Aging Cell, Journal of Pharmaceutical and Biomedical Analysis, The Journals of Gerontology Series A, and Metabolomics, indicating a focus on aging, biomedical analysis, and metabolic research themes.

Their published outputs show a consistent interest in aging and metabolism, combined with molecular and pharmacological approaches. This includes the use of proteomics and metabolomics techniques, which are central to several of the listed publication venues and research topics.

Best Publications

  • NMDAR inhibition-independent antidepressant actions of ketamine metabolites

    Panos Zanos;Ruin Moaddel;Patrick J. Morris;Polymnia Georgiou

  • SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

    Nathan L. Price;Ana P. Gomes;Alvin J.Y. Ling;Filipe V. Duarte

  • Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

    Panos Zanos;Ruin Moaddel;Patrick J. Morris;Lace M. Riggs

  • Plasma proteomic signature of age in healthy humans.

    Toshiko Tanaka;Angelique Biancotto;Ruin Moaddel;Ann Zenobia Moore

  • A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

    Morten Scheibye-Knudsen;Sarah J. Mitchell;Sarah J. Mitchell;Evandro F. Fang;Teruaki Iyama

  • Child Stunting is Associated with Low Circulating Essential Amino Acids

    Richard D. Semba;Michelle Shardell;Fayrouz A. Sakr Ashour;Ruin Moaddel

  • Relationship of Ketamine’s Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

    Carlos A. Zarate;Nancy Brutsche;Gonzalo Laje;David A. Luckenbaugh

  • Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet

    Yolanda Jimenez-Gomez;Julie A. Mattison;Kevin J. Pearson;Kevin J. Pearson;Alejandro Martin-Montalvo

  • Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects

    Allison C. Nugent;Elizabeth D. Ballard;Todd D. Gould;Lawrence T. Park

  • Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien;Alexey Lyashkov;Marta Gonzalez-Freire;Ravi Tharakan

  • High-potency ligands for DREADD imaging and activation in rodents and monkeys

    Jordi Bonaventura;Mark A. G. Eldridge;Feng Hu;Juan L. Gomez

  • Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors.

    Ruin Moaddel;Galia Abdrakhmanova;Joanna Kozak;Krzysztof Jozwiak

  • Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

    Eric W. Lumsden;Timothy A. Troppoli;Scott J. Myers;Panos Zanos

  • Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells

    Wook Kim;Máire E. Doyle;Zhuo Liu;Qizong Lao

  • Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells

    Catalina Lee-Chang;Monica Bodogai;Alejandro Martin-Montalvo;Katarzyna Wejksza

  • Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

    Jennifer L. Fiori;Yu Kyong Shin;Yu Kyong Shin;Wook Kim;Wook Kim;Susan M. Krzysik-Walker

  • Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

    Xiaochen Zhao;Swarajya Lakshmi Vattem Venkata;Ruin Moaddel;Dave A. Luckenbaugh

  • Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization.

    Haruyo Sambe;Kaori Hoshina;Ruin Moaddel;Irving W. Wainer

  • A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome

    Ruin Moaddel;Swarajya Lakshmi Vattem Venkata;Mary J. Tanga;James E. Bupp

  • Comparison of analytical techniques for the identification of bioactive compounds from natural products

    Łukasz Cieśla;Łukasz Cieśla;Ruin Moaddel

Frequent Co-Authors

Luigi Ferrucci
Luigi Ferrucci National Institutes of Health
Carlos A. Zarate
Carlos A. Zarate National Institutes of Health
Richard D. Semba
Richard D. Semba Johns Hopkins University School of Medicine
Todd D. Gould
Todd D. Gould University of Maryland, Baltimore
Michel Bernier
Michel Bernier National Institutes of Health
Craig J. Thomas
Craig J. Thomas National Institutes of Health
Josephine M. Egan
Josephine M. Egan National Institutes of Health
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Toshiko Tanaka
Toshiko Tanaka National Institutes of Health

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