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Biology and Biochemistry

D-Index
70
Citations
15591
World Ranking
7097
National Ranking
3263

Overview

Pamela J. Lein is affiliated with the University of California, Davis in the United States. Their research spans across multiple areas within biochemistry, genetics, molecular biology, and neuroscience. Lein's published work primarily focuses on toxicology, neuroinflammation, and neurodegenerative mechanisms, with particular interest in the impacts of environmental toxins and pesticide exposure on neurological health.

Lein has contributed to the fields of biochemistry, genetics, and molecular biology as well as neuroscience, with an equal number of publications (75) in each. Within these broad fields, their research delves into specific subfields such as health, toxicology, and mutagenesis (59 publications), molecular biology (45), cellular and molecular neuroscience (30), plant science (21), and neurology (17).

The primary topics covered in their research include neuroscience and neuropharmacology, pesticide exposure and toxicity, neuroinflammation and neurodegeneration mechanisms, environmental toxicology and ecotoxicology, air quality and health impacts, toxic organic pollutants, and anesthesia-related neurotoxicity. These focus areas reflect an interdisciplinary approach combining molecular insights with environmental health perspectives.

Lein's recent publications illustrate the scope and focus of their work:

  • Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions, 2022, Progress in Lipid Research
  • A non-hallucinogenic psychedelic analogue with therapeutic potential, 2020, Nature
  • A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation, 2020, Journal of Neuroinflammation
  • Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity, 2020, International Journal of Molecular Sciences
  • Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth, 2020, ACS Pharmacology & Translational Science

Frequent coauthors in Lein's research include Anthony E. Valenzuela, Donald A. Bruun, Danielle Harvey, Ana Cristina Grodzki, and Keith J. Bein. This collaborative network suggests interdisciplinary and multi-institutional research efforts.

Lein's work has been published extensively in several venues, with the most frequent being bioRxiv (Cold Spring Harbor Laboratory) with 13 publications, Open Access Government with 12, NeuroToxicology with 9, Archives of Toxicology with 5, and Frontiers in Toxicology with 4 publications. This distribution reflects an active presence in both open-access platforms and specialized journals related to toxicology and neurological research.

Best Publications

  • A non-hallucinogenic psychedelic analogue with therapeutic potential

    Lindsay P. Cameron;Robert J. Tombari;Ju Lu;Alexander J. Pell

  • OSTEOGENIC PROTEIN-1 INDUCES DENDRITIC GROWTH IN RAT SYMPATHETIC NEURONS

    Pamela J Lein;Mary Johnson;Xin Guo;David Rueger

  • Mutant IDH1 and seizures in patients with glioma.

    Hao Chen;Jonathon Judkins;Cheddhi Thomas;Meijing Wu

  • Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

    Isaac N. Pessah;Gennady Cherednichenko;Pamela J. Lein

  • A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation.

    Christopher N. Banks;Pamela J. Lein

  • Using the Morris Water Maze to Assess Spatial Learning and Memory in Weanling Mice

    Christopher D. Barnhart;Dongren Yang;Pamela J. Lein

  • CORRELATING NEUROBEHAVIORAL PERFORMANCE WITH BIOMARKERS OF ORGANOPHOSPHOROUS PESTICIDE EXPOSURE

    Diane S. Rohlman;W. Kent Anger;Pamela J. Lein

  • Workgroup Report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

    Sandra Coecke;Alan M. Goldberg;Sandra Allen;Leonora Buzanska

  • Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

    Dongren Yang;Kyung Ho Kim;Andrew Phimister;Adam D. Bachstetter

  • Neurotoxicity of polychlorinated biphenyls and related organohalogens

    Isaac N. Pessah;Pamela J. Lein;Richard F. Seegal;Sharon K. Sagiv

  • Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures.

    Angela S. Howard;Robert Bucelli;David A. Jett;Donald Bruun

  • Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons.

    Rosemary A Schuh;Pamela J Lein;Rondell A Beckles;David A Jett

  • Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.

    Kevin M Crofton;William R Mundy;Pamela J Lein;Anna Bal-Price

  • Intravenous Administration of Bone Morphogenetic Protein-7 After Ischemia Improves Motor Function in Stroke Rats

    Chen Fu Chang;Shinn Zong Lin;Yung Hsiao Chiang;Marisela Morales

  • Distinct spatial localization of specific mRNAs in cultured sympathetic neurons

    David A. Bruckenstein;Pamela J. Lein;Dennis Higgins;Robert T. Fremeau;Robert T. Fremeau

  • Nanoporous gold as a neural interface coating: Effects of topography, surface chemistry, and feature size

    Christopher A. R. Chapman;Hao Chen;Marianna Stamou;Juergen Biener

  • The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin.

    Pamela J. Lein;Dennis Higgins;David C. Turner;Leonard A. Flier

  • PCB-95 Promotes Dendritic Growth via Ryanodine Receptor–Dependent Mechanisms

    Gary A. Wayman;Dongren Yang;Diptiman D. Bose;Adam Lesiak

  • A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation.

    Noah Goshi;Rhianna K. Morgan;Pamela J. Lein;Erkin Seker

  • DNA methylation: A mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

    Kimberly P. Keil;Pamela J. Lein

Frequent Co-Authors

Isaac N. Pessah
Isaac N. Pessah University of California, Davis
Danielle J Harvey
Danielle J Harvey University of California, Davis
Hans-Joachim Lehmler
Hans-Joachim Lehmler University of Iowa
Michael A. Rogawski
Michael A. Rogawski University of California, Davis
Heike Wulff
Heike Wulff University of California, Davis
Bruce D. Hammock
Bruce D. Hammock University of California, Davis
Daniel J. Tancredi
Daniel J. Tancredi University of California, Davis
Craig Horbinski
Craig Horbinski Northwestern University
Anthony S. Wexler
Anthony S. Wexler University of California, Davis
Gary A. Wayman
Gary A. Wayman Washington State University

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