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Biology and Biochemistry

D-Index
64
Citations
12183
World Ranking
9843
National Ranking
4314

Overview

Susan L. Hamilton is affiliated with Baylor College of Medicine in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a significant focus on medicine. Within these fields, they have contributed extensively to subfields including molecular biology, cardiology and cardiovascular medicine, cellular and molecular neuroscience, physiology, and cell biology.

Their research concentrates on several specialized topics, including:

  • Ion channel regulation and function
  • Cardiomyopathy and myosin studies
  • Genetic neurodegenerative diseases
  • Cardiovascular effects of exercise
  • Muscle physiology and disorders
  • Adipose tissue and metabolism
  • Cardiac electrophysiology and arrhythmias

Hamilton has authored multiple papers, some of the recent notable publications include:

  • Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature, 2020, Skeletal Muscle
  • MyoSight-semi-automated image analysis of skeletal muscle cross sections, 2020, Skeletal Muscle
  • Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation, 2020, Nature Communications
  • Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility, 2022, Nature Communications
  • Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients, 2021, Canadian Journal of Anesthesia/Journal canadien d anesthésie

Frequent co-authors in their collaborative research include Chang Seok Lee, Amy D. Hanna, Sung Yun Jung, Rachel Sue Zhen Yee, and Robert T. Dirksen. The researcher has multiple publications in prominent journals such as Skeletal Muscle, Nature Communications, Canadian Journal of Anesthesia/Journal canadien d anesthésie, Communications Biology, and The FASEB Journal.

Best Publications

  • Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

    Johanna T. Lanner;Dimitra K. Georgiou;Aditya D. Joshi;Susan L. Hamilton

  • Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

    Weinian Shou;Bahman Aghdasi;Dawna L. Armstrong;Qiuxia Guo

  • RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice

    William J. Durham;Paula Aracena-Parks;Cheng Long;Ann E. Rossi

  • The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

    A Yatani;Y Imoto;J Codina;S L Hamilton

  • Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis.

    R G Smith;S Hamilton;F Hofmann;T Schneider

  • Identification of Cysteines Involved in S-Nitrosylation, S-Glutathionylation, and Oxidation to Disulfides in Ryanodine Receptor Type 1

    Paula Aracena-Parks;Sanjeewa A. Goonasekera;Charles P. Gilman;Robert T. Dirksen

  • Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel.

    Irina I. Serysheva;Elena V. Orlova;Elena V. Orlova;Wah Chiu;Michael B. Sherman

  • Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel.

    A Chu;M Díaz-Muñoz;M J Hawkes;K Brush

  • Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.

    Charles A. Hoeffer;Wei Tang;Helen Wong;Arturo Santillan

  • Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy

    Prince J. Kannankeril;Brett M. Mitchell;Sanjeewa A. Goonasekera;Mihail G. Chelu

  • Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel.

    Jennifer L. Fallon;D. Brent Halling;Susan L. Hamilton;Florante A. Quiocho

  • Two structural configurations of the skeletal muscle calcium release channel.

    Elena V. Orlova;Elena V. Orlova;Irina I. Serysheva;Marin van Heel;Marin van Heel;Susan L. Hamilton

  • Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse

    Mihail G. Chelu;Sanjeewa A. Goonasekera;William J. Durham;Wei Tang

  • Identification of Calcium Release-triggering and Blocking Regions of the II-III Loop of the Skeletal Muscle Dihydropyridine Receptor

    Roque El-Hayek;Bozena Antoniu;Jianping Wang;Susan L. Hamilton

  • Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin).

    M Díaz-Muñoz;S L Hamilton;M A Kaetzel;P Hazarika

  • Regulation of Voltage-Gated Ca2+ Channels by Calmodulin

    D. Brent Halling;Paula Aracena-Parks;Susan L. Hamilton

  • The Pore Structure of the Closed RyR1 Channel

    Steven J. Ludtke;Irina I. Serysheva;Susan L. Hamilton;Wah Chiu

  • Nitric oxide protects the skeletal muscle Ca2+ release channel from oxidation induced activation

    Bahman Aghdasi;Michael B. Reid;Susan L. Hamilton

  • Apocalmodulin and Ca2+ calmodulin bind to the same region on the skeletal muscle Ca2+ release channel

    Catherine Porter Moore;George Rodney;Jia Zheng Zhang;Lucia Santacruz-Toloza

  • Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel

    C. Callaway;A. Seryshev;J.P. Wang;K.J. Slavik

Frequent Co-Authors

Robert T. Dirksen
Robert T. Dirksen University of Rochester
Wah Chiu
Wah Chiu Stanford University
Elena V. Orlova
Elena V. Orlova Birkbeck, University of London
Cecilia Hidalgo
Cecilia Hidalgo University of Chile
Michael B. Reid
Michael B. Reid University of Florida
Florante A. Quiocho
Florante A. Quiocho Baylor College of Medicine
Feliciano Protasi
Feliciano Protasi University of Chieti-Pescara
Arthur Karlin
Arthur Karlin Columbia University
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Eric Klann
Eric Klann New York University

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