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Molecular Biology

D-Index
49
Citations
13867
World Ranking
2604
National Ranking
1277

Overview

Jeongwu Lee is a researcher affiliated with Case Western Reserve University in the United States. Their work spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology, with a focus on molecular mechanisms relevant to cancer and immune responses.

The scientist's research covers primary topics such as glioma diagnosis and treatment, immune cells in cancer, cancer-related hypoxia and metabolism, neutrophil and oxidative mechanisms, COVID-19 clinical research, epigenetics and DNA methylation, and microRNA in disease regulation.

Key recent publications by Jeongwu Lee include:

  • ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages, 2020, Nature Communications
  • Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma, 2020, Genome biology
  • Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling, 2023, Cancer Cell
  • Tissue factor links inflammation, thrombosis, and senescence in COVID-19, 2022, Scientific Reports
  • Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma, 2020, Brain

Frequent collaborators include:

  • Do-Hyun Nam
  • Sung Soo Kim
  • Young Taek Oh
  • K. Jason
  • Dayna Nguyen

Their research has been published across several scientific venues, including:

  • Nature Communications
  • Genome Biology
  • Cancer Cell
  • Scientific Reports
  • Brain

Jeongwu Lee's scientific contributions emphasize molecular biology and immunology within the context of cancer research and infectious diseases. Their investigations into signaling pathways, transcriptional networks, and tissue remodeling in glioblastoma highlight a multidisciplinary approach linking cancer biology to immune system dynamics and inflammation.

Best Publications

  • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

    Jeongwu Lee;Svetlana Kotliarova;Yuri Kotliarov;Aiguo Li

  • microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

    Benjamin Kefas;Jakub Godlewski;Laurey Comeau;Yunqing Li

  • SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

    Myung Jin Son;Kevin D Woolard;Do Hyun Nam;Jeongwu Lee

  • The Fas System is a Key Regulator of Germ Cell Apoptosis in the Testis

    Jeongwu Lee;J. H. Richburg;S. C. Younkin;K. Boekelheide

  • Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

    Eunhee Kim;Misuk Kim;Dong Hun Woo;Yongjae Shin

  • Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

    Benjamin W. Purow;Raqeeb M. Haque;Martha W. Noel;Qin Su

  • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.

    Jeongwu Lee;Myung Jin Son;Kevin D Woolard;Nicholas M. Donin

  • Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury

    Lixin Sun;Jeongwu Lee;Howard A. Fine

  • Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

    Christine E. Eyler;Qiulian Wu;Kenneth Yan;Jennifer M. MacSwords

  • Spatiotemporal Evolution of the Primary Glioblastoma Genome

    Jinkuk Kim;Jinkuk Kim;In Hee Lee;Hee Jin Cho;Hee Jin Cho;Chul Kee Park

  • Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-κB, and glucose regulation

    Svetlana Kotliarova;Sandra Pastorino;Lara C. Kovell;Yuri Kotliarov

  • Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

    Olga A. Guryanova;Qiulian Wu;Lin Cheng;Lin Cheng;Justin D Lathia

  • WNT signaling in glioblastoma and therapeutic opportunities.

    Yeri Lee;Jin Ku Lee;Sun Hee Ahn;Jeongwu Lee

  • The Neuronal MicroRNA miR-326 Acts in a Feedback Loop with Notch and Has Therapeutic Potential against Brain Tumors

    Benjamin Kefas;Laurey Comeau;Desiree H. Floyd;Oleksandr Seleverstov

  • Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ

    Kyeung Min Joo;Jinkuk Kim;Juyoun Jin;Misuk Kim

  • Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.

    Chad M. Toledo;Chad M. Toledo;Yu Ding;Pia Hoellerbauer;Pia Hoellerbauer;Ryan J. Davis;Ryan J. Davis

  • Wnt activation is implicated in glioblastoma radioresistance

    Yonghyun Kim;Kang Ho Kim;Kang Ho Kim;Jeena Lee;Jeena Lee;Young Ae Lee;Young Ae Lee

  • EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner.

    Sung Hak Kim;Kaushal Joshi;Ravesanker Ezhilarasan;Toshia R. Myers

  • MET signaling regulates glioblastoma stem cells

    Kyeung Min Joo;Juyoun Jin;Eunhee Kim;Kang Ho Kim

  • Notch-1 regulates transcription of the epidermal growth factor receptor through p53

    Benjamin W. Purow;Tilak K. Sundaresan;Tilak K. Sundaresan;Michael J. Burdick;Benjamin A. Kefas

Frequent Co-Authors

Do-Hyun Nam
Do-Hyun Nam Samsung Medical Center
Howard A. Fine
Howard A. Fine Cornell University
Jeremy N. Rich
Jeremy N. Rich University of Pittsburgh
Ichiro Nakano
Ichiro Nakano University of Alabama at Birmingham
Justin D. Lathia
Justin D. Lathia Cleveland Clinic Lerner College of Medicine
Steven M. Pollard
Steven M. Pollard University of Edinburgh
James M. Olson
James M. Olson Fred Hutchinson Cancer Research Center
Woong-Yang Park
Woong-Yang Park Samsung Medical Center
Cheolju Lee
Cheolju Lee Korea Institute of Science and Technology
Dragan Maric
Dragan Maric National Institutes of Health

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