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Medicine

D-Index
94
Citations
35469
World Ranking
10413
National Ranking
5364

Research.com Recognitions

  • 2017 - National Institutes of Health Director's Pioneer Award

Overview

Howard A. Fine is affiliated with Cornell University in the United States and specializes in medical research with a focus on genetics and molecular biology. Their work prominently addresses cancer research, particularly related to glioma diagnosis and treatment.

The areas of study relevant to Fine's research include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Fine's subfields of study encompass genetics, molecular biology, cancer research, pulmonary and respiratory medicine, and radiology, nuclear medicine, and imaging.

  • Genetics
  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Radiology, Nuclear Medicine and Imaging

Their research addresses various specific topics, including glioma diagnosis and treatment, brain metastases and treatment, cancer hypoxia and metabolism, management of meningioma and schwannoma, cancer cells and metastasis, immune cells in cancer, and single-cell and spatial transcriptomics.

  • Glioma Diagnosis and Treatment
  • Brain Metastases and Treatment
  • Cancer, Hypoxia, and Metabolism
  • Meningioma and schwannoma management
  • Cancer Cells and Metastasis
  • Immune cells in cancer
  • Single-cell and spatial transcriptomics

Frequent publication venues for Fine's work include Neuro-Oncology, Cancer Discovery, Cancer Cell, World Neurosurgery, and bioRxiv (Cold Spring Harbor Laboratory).

  • Neuro-Oncology
  • Cancer Discovery
  • Cancer Cell
  • World Neurosurgery
  • bioRxiv (Cold Spring Harbor Laboratory)

Collaborators regularly working with Fine include Rajiv Magge, Rohan Ramakrishna, Stéfano M. Cirigliano, Theodore H. Schwartz, and David J. Pisapia.

  • Rajiv Magge
  • Rohan Ramakrishna
  • Stéfano M. Cirigliano
  • Theodore H. Schwartz
  • David J. Pisapia

Recent publications by Fine feature research in cancer biology and therapeutic approaches, notably:

  • Diffuse Glioma Heterogeneity and Its Therapeutic Implications, 2021, Cancer Discovery
  • Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate, 2021, Proceedings of the National Academy of Sciences
  • Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas, 2020, Cancer Discovery
  • Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling, 2023, Cancer Cell
  • Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell Resolution, 2023, Cancer Research

Howard A. Fine has been recognized with the National Institutes of Health Director's Pioneer Award in 2017.

Best Publications

  • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

    Jeongwu Lee;Svetlana Kotliarova;Yuri Kotliarov;Aiguo Li

  • Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

    Teri N. Kreisl;Lyndon Kim;Kraig Moore;Paul Duic

  • Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

    Lixin Sun;Ai Min Hui;Qin Su;Alexander Vortmeyer

  • microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

    Benjamin Kefas;Jakub Godlewski;Laurey Comeau;Yunqing Li

  • SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

    Myung Jin Son;Kevin D Woolard;Do Hyun Nam;Jeongwu Lee

  • Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

    Benjamin W. Purow;Raqeeb M. Haque;Martha W. Noel;Qin Su

  • Stereotactic Radiosurgery for the Definitive, Noninvasive Treatment of Brain Metastases

    Eben Alexander;Thomas M. Moriarty;Roger B. Davis;Patrick Y. Wen

  • Cellular-Telephone Use and Brain Tumors

    Peter D. Inskip;Robert E. Tarone;Elizabeth E. Hatch;Timothy C. Wilcosky

  • Phase II Trial of the Antiangiogenic Agent Thalidomide in Patients With Recurrent High-Grade Gliomas

    Howard A. Fine;William D. Figg;Kurt Jaeckle;Patrick Y. Wen

  • Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma

    Wolfgang Wick;Vinay K. Puduvalli;Marc C. Chamberlain;Martin J. van den Bent

  • Primary Central Nervous System Lymphoma

    Howard A. Fine;Robert J. Mayer

  • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.

    Jeongwu Lee;Myung Jin Son;Kevin D Woolard;Nicholas M. Donin

  • Modeling Patient-Derived Glioblastoma with Cerebral Organoids.

    Amanda Linkous;Demosthenes Balamatsias;Matija Snuderl;Lincoln Edwards

  • Phase I/II Study of Imatinib Mesylate for Recurrent Malignant Gliomas: North American Brain Tumor Consortium Study 99-08

    Patrick Y. Wen;W. K Alfred Yung;Kathleen R. Lamborn;Patricia L. Dahia

  • Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas.

    Kathleen R. Lamborn;W. K.Alfred Yung;Susan M. Chang;Patrick Y. Wen

  • Rembrandt: helping personalized medicine become a reality through integrative translational research.

    Subha Madhavan;Jean Claude Zenklusen;Yuri Kotliarov;Himanso Sahni

  • The treatment of recurrent brain metastases with stereotactic radiosurgery.

    Jay S. Loeffler;Hanne M. Kooy;Patrick Y. Wen;Howard A. Fine

  • Scale to Predict Survival After Surgery for Recurrent Glioblastoma Multiforme

    John K. Park;Tiffany Hodges;Leopold Arko;Michael Shen

  • A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy

    Jeffrey J. Raizer;Lauren E. Abrey;Andrew B. Lassman;Susan M. Chang

  • Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme

    Dennis C. Shrieve;Eben Alexander;Patrick Y. Wen;Howard A. Fine

Frequent Co-Authors

Patrick Y. Wen
Patrick Y. Wen Harvard University
Peter McL. Black
Peter McL. Black University of British Columbia
Jay S. Loeffler
Jay S. Loeffler Harvard University
Michael D. Prados
Michael D. Prados University of California, San Francisco
Martha S. Linet
Martha S. Linet National Institutes of Health
W. K. Alfred Yung
W. K. Alfred Yung The University of Texas MD Anderson Cancer Center
Timothy F. Cloughesy
Timothy F. Cloughesy University of California, Los Angeles
Jeongwu Lee
Jeongwu Lee Case Western Reserve University
Minesh P. Mehta
Minesh P. Mehta University of Maryland, Baltimore
Susan M. Chang
Susan M. Chang University of California, San Francisco

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