World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
27042
World Ranking
5228
National Ranking
2484

Research.com Recognitions

  • 2005 - Polish Academy of Science

Overview

Piotr Sicinski is affiliated with Harvard University in the United States and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research has primarily focused on molecular biology, oncology, pulmonary and respiratory medicine, cell biology, and genetics.

The scientist's main topics of work include:

  • Cancer-related Molecular Pathways
  • Advanced Breast Cancer Therapies
  • Ubiquitin and Proteasome Pathways
  • RNA Modifications and Cancer
  • Chronic Lymphocytic Leukemia Research
  • Cancer Immunotherapy and Biomarkers
  • Microtubule and Mitosis Dynamics

Frequent coauthors in Sicinski's research collaborations are Anne Fassl, Chen Chu, Samanta Sharma, Steven P. Gygi, and Jan M. Suski. Their work appears in several notable scientific venues, including Nature Communications, Cell Cycle, Cancer Cell, Science, and Molecular Cell, each featuring multiple publications by Sicinski.

Selected recent papers include:

  • "Targeting cell-cycle machinery in cancer" (2021) published in Cancer Cell
  • "CDK4 and CDK6 kinases: From basic science to cancer therapy" (2022) published in Science
  • "Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy" (2020) published in Nature Cell Biology
  • "Cyclin E in normal physiology and disease states" (2021) published in Trends in Cell Biology
  • "Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells" (2020) published in Molecular Cell

The award of the Polish Academy of Science was conferred on Sicinski in 2005.

Best Publications

  • Cell Cycle Proteins as Promising Targets in Cancer Therapy

    Tobias Otto;Piotr Sicinski

  • The molecular basis of muscular dystrophy in the mdx mouse: a point mutation

    Piotr Sicinski;Yan Geng;Allan S. Ryder-Cook;Eric A. Barnard

  • Cyclin D1 provides a link between development and oncogenesis in the retina and breast

    Piotr Sicinski;Joana Liu Donaher;Susan B. Parker;Susan B. Parker;Tiansen Li

  • Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

    Piotr Sicinski;Joana Liu Donaher;Yan Geng;Susan B. Parker

  • Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

    Jinfang Zhang;Xia Bu;Haizhen Wang;Yasheng Zhu

  • Cyclin E ablation in the mouse.

    Yan Geng;Qunyan Yu;Ewa Sicinska;Ewa Sicinska;Manjusri Das

  • Mouse development and cell proliferation in the absence of D-cyclins.

    Katarzyna Kozar;Maria A. Ciemerych;Vivienne I. Rebel;Hirokazu Shigematsu

  • Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

    Caroline Bouchard;Katja Thieke;Antje Maier;Rainer Saffrich

  • A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.

    Lars Anders;Nan Ke;Per Hydbring;Yoon J. Choi

  • Requirement for CDK4 kinase function in breast cancer

    Qunyan Yu;Ewa Sicinska;Yan Geng;Marie Ahnström

  • Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

    Per Hydbring;Marcos Malumbres;Piotr Sicinski

  • Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

    Yan Geng;Wendy Whoriskey;Mary Y Park;Roderick T Bronson

  • The requirement for cyclin D function in tumor maintenance.

    Yoon Jong Choi;Xiaoyu Li;Per Hydbring;Takaomi Sanda;Takaomi Sanda

  • Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

    Anil M Narasimha;Manuel Kaulich;Gary S Shapiro;Yoon J Choi

  • Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors

    Shom Goel;Qi Wang;April C. Watt;Sara M. Tolaney

  • Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

    Jake A. Kushner;Maria A. Ciemerych;Ewa Sicinska;Lynn M. Wartschow

  • Requirement for cyclin D3 in lymphocyte development and T cell leukemias.

    Ewa Sicinska;Iannis Aifantis;Laurent Le Cam;Wojciech Swat

  • Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    Pengda Liu;Michael Begley;Wojciech Michowski;Hiroyuki Inuzuka

  • Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

    Mark W. Landis;Mark W. Landis;Basil S. Pawlyk;Tiansen Li;Piotr Sicinski

  • A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

    Siwanon Jirawatnotai;Yiduo Hu;Wojciech Michowski;Joshua E. Elias;Joshua E. Elias

Frequent Co-Authors

Christian Trautwein
Christian Trautwein RWTH Aachen University
Steven P. Gygi
Steven P. Gygi Harvard University
Mariano Barbacid
Mariano Barbacid Spanish National Cancer Research Centre
Kornelia Polyak
Kornelia Polyak Harvard University
Roderick T. Bronson
Roderick T. Bronson Harvard University
Wenyi Wei
Wenyi Wei Beth Israel Deaconess Medical Center
Joshua E. Elias
Joshua E. Elias Stanford University
Ralf Weiskirchen
Ralf Weiskirchen RWTH Aachen University
Koichi Akashi
Koichi Akashi Kyushu University
Debra J. Wolgemuth
Debra J. Wolgemuth Columbia University Medical Center

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