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D-Index & Metrics

Molecular Biology

D-Index
68
Citations
18246
World Ranking
1506
National Ranking
117

Overview

Denise Sheer is affiliated with Queen Mary University of London in the United Kingdom. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focus on subfields such as molecular biology, cancer research, neurology, genetics, and immunology.

The scientist's work explores a variety of topics including glioma diagnosis and treatment, immune cells in cancer, epigenetics and DNA methylation, cancer-related molecular mechanisms research, amyotrophic lateral sclerosis research, neurological diseases and metabolism, and microRNA in disease regulation.

Recent notable publications include:

  • Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment (2020, The EMBO Journal)
  • Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates (2020, EMBO Reports)
  • Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma (2021, Nature Communications)
  • Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders (2021, Brain Communications)
  • Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape (2022, eLife)

Denise Sheer frequently collaborates with other researchers, including T. Alwyn Jones, Nicola Pomella, Gabriel Rosser, Loredana Guglielmi, and Claire Vinel.

Their publications are often found in venues such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Neuro-Oncology, The EMBO Journal, and EMBO Reports.

Best Publications

  • Localization of the gene for familial adenomatous polyposis on chromosome 5.

    W F Bodmer;C J Bailey;J Bodmer;H J Bussey

  • The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

    O Delattre;J Zucman;T Melot;X S Garau

  • Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

    Julian Borrow;Audrey D. Goddard;Denise Sheer;Ellen Solomon

  • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

    Jinghui Zhang;Gang Wu;Claudia P. Miller;Ruth G. Tatevossian

  • Plasticity in the organization and sequences of human KIR/ILT gene families

    Michael J. Wilson;Michaela Torkar;Anja Haude;Sarah Milne

  • Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

    J Zucman;T Melot;C Desmaze;J Ghysdael

  • Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei

    E.V. Volpi;E. Chevret;T. Jones;R. Vatcheva

  • The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.

    Hanan Lamlum;Mohammad Ilyas;Andrew Rowan;Susan Clark

  • The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain

    Andrew J. Saurin;Carol Shiels;Jill Williamson;David P.E. Satijn

  • Comparative Genomic Hybridization of Breast Tumors Stratified by Histological Grade Reveals New Insights into the Biological Progression of Breast Cancer

    Rebecca Roylance;Patricia Gorman;William Harris;Rachael Liebmann

  • Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

    Tim Forshew;Ruth G Tatevossian;Ruth G Tatevossian;Andrew R J Lawson;Jing Ma

  • Isolation of cDNA clones encoding the β isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

    John R. Jenkins;Paul Ayton;Tania Jones;Sally L. Davies

  • Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions.

    Jayson Wang;Carol Shiels;Peter Sasieni;Pei Jun Wu

  • Subchromosomal Positioning of the Epidermal Differentiation Complex (EDC) in Keratinocyte and Lymphoblast Interphase Nuclei

    Ruth R.E. Williams;Simon Broad;Denise Sheer;Jiannis Ragoussis

  • Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule.

    Jenny Dunne;Andrew M. Hanby;Richard Poulsom;Tania A. Jones

  • The role of microhomology in genomic structural variation

    Diego Ottaviani;Magdalena LeCain;Denise Sheer

  • Chromosomal localisation of the human homologues to the oncogenes erbA and B.

    N.K. Spurr;E. Solomon;M. Jansson;D. Sheer

  • Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome.

    P. Goodfellow;G. Banting;D. Sheer;H. H. Ropers

  • Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins

    Mônica P. Belich;Richard J. Glynne;Gabriele Senger;Denise Sheer

  • Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

    Wael M. Abdel-Rahman;Kanade Katsura;Willem Rens;Patricia A. Gorman

Frequent Co-Authors

Ellen Solomon
Ellen Solomon King's College London
Nigel K. Spurr
Nigel K. Spurr GlaxoSmithKline (United Kingdom)
Walter F. Bodmer
Walter F. Bodmer University of Oxford
Stephan Beck
Stephan Beck University College London
David W. Ellison
David W. Ellison St. Jude Children's Research Hospital
Janet Shipley
Janet Shipley Institute of Cancer Research
John Trowsdale
John Trowsdale University of Cambridge
Paul S. Freemont
Paul S. Freemont Imperial College London
Jiannis Ragoussis
Jiannis Ragoussis McGill University
Eugene R. Zabarovsky
Eugene R. Zabarovsky Karolinska Institute

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