World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
10782
World Ranking
9917
National Ranking
338

Overview

Lori Frappier is affiliated with the University of Toronto in Canada and has contributed extensively to the field of Medicine, with a focus on oncology, epidemiology, infectious diseases, immunology, and public health. Their research encompasses a variety of specialized areas including viral-associated cancers and disorders, cytomegalovirus and herpesvirus research, viral gastroenteritis research and epidemiology, SARS-CoV-2 and COVID-19 research, interferon and immune responses, lymphoma diagnosis and treatment, as well as herpesvirus infections and treatments.

The scientist has frequently published in several notable venues, demonstrating active engagement in virology and related disciplines. These publication venues include:

  • Journal of Virology
  • PLoS Pathogens
  • Tumour Virus Research
  • Viruses
  • Virology

Frappier's recent papers include the following:

  • Epstein-Barr virus: Current questions and challenges, 2021, Tumour Virus Research
  • Virology under the Microscope-a Call for Rational Discourse, 2023, Journal of Virology
  • Flavivirus Capsid Proteins Inhibit the Interferon Response, 2022, Viruses
  • Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3, 2021, Virology
  • Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function, 2022, PLoS Pathogens

Their work involves collaboration with several frequent co-authors, indicative of recurring research partnerships. These collaborators include:

  • Kathy Shire
  • Felicia Goodrum
  • Anice C. Lowen
  • Seema S. Lakdawala
  • James C. Alwine

Best Publications

  • Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

    Alexey Bochkarev;Richard A. Pfuetzner;Aled M. Edwards;Lori Frappier

  • Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.

    Vivian Saridakis;Yi Sheng;Feroz Sarkari;Melissa N. Holowaty

  • Molecular recognition of p53 and MDM2 by USP7/HAUSP

    Yi Sheng;Vivian Saridakis;Feroz Sarkari;Shili Duan

  • Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing.

    Neil Blake;Steven Lee;Irina Redchenko;Wendy Thomas

  • Structural Basis for the Recognition of DNA Repair Proteins UNG2, XPA, and RAD52 by Replication Factor RPA

    Georges Mer;Alexey Bochkarev;Alexey Bochkarev;Rajesh Gupta;Elena Bochkareva

  • Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7.

    Melissa N. Holowaty;Mahel Zeghouf;Hong Wu;Judy Tellam

  • Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA.

    Alexey Bochkarev;Jean A Barwell;Richard A Pfuetzner;Elena Bochkareva

  • The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single‐stranded DNA binding

    Alexey Bochkarev;Alexey Bochkarev;Elena Bochkareva;Elena Bochkareva;Lori Frappier;Aled M. Edwards;Aled M. Edwards

  • EBP2, a Human Protein That Interacts with Sequences of the Epstein-Barr Virus Nuclear Antigen 1 Important for Plasmid Maintenance

    Kathy Shire;Derek F. J. Ceccarelli;Tina M. Avolio-Hunter;Lori Frappier

  • Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.

    Melissa N. Holowaty;Yi Sheng;Tin Nguyen;Cheryl Arrowsmith

  • Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA1

    Alexey Bochkarev;Jean A. Barwell;Richard A. Pfuetzner;William Furey

  • Overproduction, purification, and characterization of EBNA1, the origin binding protein of Epstein-Barr virus.

    L Frappier;M O'Donnell

  • Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies.

    Nirojini Sivachandran;Feroz Sarkari;Lori Frappier

  • The RPA32 Subunit of Human Replication Protein A Contains a Single-stranded DNA-binding Domain

    Elena Bochkareva;Lori Frappier;Aled M. Edwards;Alexey Bochkarev

  • EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication.

    Feroz Sarkari;Teresa Sanchez-Alcaraz;Shan Wang;Melissa N. Holowaty

  • Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus.

    Lori Frappier;Mike O'Donnell

  • Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1.

    Hong Wu;Priya Kapoor;Lori Frappier

  • Functions of the Epstein-Barr Virus EBNA1 Protein in Viral Reactivation and Lytic Infection

    Nirojini Sivachandran;Xueqi Wang;Lori Frappier

  • Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival

    Lori Frappier

  • Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

    Edyta Marcon;Harshika Jain;Anandi Bhattacharya;Hongbo Guo

Frequent Co-Authors

Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Jack Greenblatt
Jack Greenblatt University of Toronto
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Mike O'Donnell
Mike O'Donnell Rockefeller University
Reuben S. Harris
Reuben S. Harris The University of Texas Health Science Center at San Antonio
Brian O'Sullivan
Brian O'Sullivan Princess Margaret Cancer Centre
Bruce E. Clurman
Bruce E. Clurman Fred Hutchinson Cancer Research Center
Marc Zapatka
Marc Zapatka German Cancer Research Center
David C. Johnson
David C. Johnson Oregon Health & Science University
Walter J. Chazin
Walter J. Chazin Vanderbilt University

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