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Immunology

D-Index
86
Citations
21668
World Ranking
1287
National Ranking
47

Medicine

D-Index
86
Citations
21668
World Ranking
14302
National Ranking
546

Overview

Jaap M. Middeldorp is affiliated with the VU University Medical Center in the Netherlands. Their research primarily spans the field of Medicine, with notable focus areas including Pediatrics, Perinatology and Child Health, Oncology, Epidemiology, Obstetrics and Gynecology, and Immunology.

The scientist's work addresses several key topics, including:

  • Viral-associated cancers and disorders
  • Assisted Reproductive Technology and Twin Pregnancy
  • Prenatal Screening and Diagnostics
  • Pregnancy and preeclampsia studies
  • Cytomegalovirus and herpesvirus research
  • Immune Cell Function and Interaction
  • Polyomavirus and related diseases

Jaap M. Middeldorp has contributed to numerous publications, with recent papers highlighting diverse areas of infectious diseases, immunology, and clinical medicine. Key recent publications include:

  • "Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom", 2020, BMC Public Health
  • "Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis", 2021, Frontiers in Immunology
  • "Post-Laser Twin Anemia Polycythemia Sequence: Diagnosis, Management, and Outcome in an International Cohort of 164 Cases", 2020, Journal of Clinical Medicine
  • "Quantitative cytokine level of TNF-α, IFN-γ, IL-10, TGF-β and circulating Epstein-Barr virus DNA load in individuals with acute Malaria due to P. falciparum or P. vivax or double infection in a Malaria endemic region in Indonesia", 2021, PLoS ONE
  • "Utility of Epstein-Barr Virus DNA in Nasopharynx Swabs as a Reflex Test to Triage Seropositive Individuals in Nasopharyngeal Carcinoma Screening Programs", 2022, Clinical Chemistry

The venues where the scientist frequently publishes include:

  • Prenatal Diagnosis
  • Ultrasound in Obstetrics and Gynecology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE
  • Fetal Diagnosis and Therapy

Collaboration has been a significant part of their work, with frequent co-authors including:

  • Enrico Lopriore
  • Femke Slaghekke
  • Monique C. Haak
  • Jeanine M.M. van Klink
  • Dick Oepkes

Best Publications

  • Functional delivery of viral miRNAs via exosomes

    D. Michiel Pegtel;Katherine Cosmopoulos;David A. Thorley-Lawson;Monique A. J. van Eijndhoven

  • Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

    Danijela Koppers-Lalic;Michael Hackenberg;Irene V. Bijnsdorp;Monique A.J. van Eijndhoven

  • Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation.

    M. Adham;A.N. Kurniawan;A.I. Muhtadi;A. Roezin

  • Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients

    Servi J. C. Stevens;Erik A. M. Verschuuren;Inge Pronk;Wim van der Bij

  • Exosomes: Fit to deliver small RNA.

    Anoek Zomer;Tineke Vendrig;Erik S Hopmans;Monique van Eijndhoven

  • Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo

    Donna Hochberg;Jaap M. Middeldorp;Michelle D. Catalina;John L. Sullivan

  • Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

    Frederik Johannes Verweij;Frederik Johannes Verweij;Frederik Johannes Verweij;Maarten P. Bebelman;Maarten P. Bebelman;Connie R. Jimenez;Juan J. Garcia-Vallejo

  • EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement.

    Josine van Beek;Axel zur Hausen;Elma Klein Kranenbarg;Cornelis J H van de Velde

  • Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9

    Cécile Keryer-Bibens;Catherine Pioche-Durieu;Cécile Villemant;Sylvie Souquère

  • Unique Transcription Pattern of Epstein-Barr Virus (EBV) in EBV-carrying Gastric Adenocarcinomas: Expression of the Transforming BARF1 Gene

    A zur Hausen;A A Brink;M E Craanen;J M Middeldorp

  • Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.

    Martin Rowe;Britt Glaunsinger;Daphne van Leeuwen;Jianmin Zuo

  • Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses

    Ann Leen;Pauline Meij;Irina Redchenko;Jaap Middeldorp

  • Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders.

    Jaap M. Middeldorp;Antoinette A.T.P Brink;Adriaan J.C van den Brule;Chris J.L.M Meijer

  • LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF‐κB activation

    Frederik J Verweij;Monique A J van Eijndhoven;Erik S Hopmans;Tineke Vendrig

  • Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze-thawing.

    Klaus Hamprecht;Jens Maschmann;Denise Müller;Klaus Dietz

  • Direct immunosuppressive effects of EBV-encoded latent membrane protein 1.

    Danny F. Dukers;Pauline Meij;Marcel B. H. J. Vervoort;Wim Vos

  • The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomes.

    John Sears;Maki Ujihara;Samantha Wong;Christopher Ott

  • Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.

    E. H. A. Spaeny-Dekking;W. L. Hanna;A. M. Wolbink;P. C. Wever

  • Comprehensive Profiling of Epstein-Barr Virus MicroRNAs in Nasopharyngeal Carcinoma

    Katherine Cosmopoulos;Michiel Pegtel;Jared Hawkins;Howell Moffett

  • Early Age at Time of Primary Epstein–Barr Virus Infection Results in Poorly Controlled Viral Infection in Infants From Western Kenya: Clues to the Etiology of Endemic Burkitt Lymphoma

    Erwan Piriou;Amolo S. Asito;Amolo S. Asito;Peter Odada Sumba;Nancy Fiore

  • Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim.

    Kostas Paschos;Paul Smith;Emma Anderton;Jaap M. Middeldorp

Frequent Co-Authors

Chris J.L.M. Meijer
Chris J.L.M. Meijer Vrije Universiteit Amsterdam
Cathrien A. Bruggeman
Cathrien A. Bruggeman Maastricht University Medical Centre
Chien-Jen Chen
Chien-Jen Chen Academia Sinica
Allan Hildesheim
Allan Hildesheim National Institutes of Health
Daniele Lilleri
Daniele Lilleri University of Pavia
Sai Wah Tsao
Sai Wah Tsao University of Hong Kong
Denise L. Doolan
Denise L. Doolan Australian Institute of Tropical Health and Medicine
David A. Thorley-Lawson
David A. Thorley-Lawson Tufts University
Gerhard Jahn
Gerhard Jahn University of Tübingen
Martin C. Harmsen
Martin C. Harmsen University Medical Center Groningen

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