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Molecular Biology

D-Index
73
Citations
18966
World Ranking
1279
National Ranking
98

Research.com Recognitions

  • 2008 - Fellow of the Royal Society of Edinburgh

Overview

Malcolm F. White is affiliated with the University of St Andrews in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant work in molecular biology and genetics. The scientist's studies also extend into medicine, covering areas such as epidemiology, public health, environmental and occupational health, and cardiology and cardiovascular medicine.

The main research topics addressed by Malcolm F. White include CRISPR and genetic engineering, cytomegalovirus and herpesvirus research, RNA and protein synthesis mechanisms, mosquito-borne diseases and control, bacterial genetics and biotechnology, viral infections and immunology research, and Vibrio bacteria research studies.

Their body of work is published extensively across several scientific venues. Frequent publication venues for their research include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Nature
  • Nature Communications
  • eLife

Numerous papers have been published by Malcolm F. White on topics related to CRISPR and immune defense mechanisms. Notable recent papers include:

  • An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity (2020), published in Nature
  • Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate (2020), published in Nature Communications
  • Cyclic nucleotide-induced helical structure activates a TIR immune effector (2022), published in Nature
  • Cyclic Nucleotide Signaling in Phage Defense and Counter-Defense (2022), published in Annual Review of Virology
  • The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence (2021), published in Nucleic Acids Research

Malcolm F. White has collaborated frequently with other researchers. Prominent co-authors include Shirley Graham, Sabine Grüschow, T.M. Gloster, Haotian Chi, and Januka S. Athukoralage.

In recognition of their contributions, they were elected as a Fellow of the Royal Society of Edinburgh in 2008.

Best Publications

  • An updated evolutionary classification of CRISPR–Cas systems

    Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa

  • Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

    Kira S. Makarova;Yuri I. Wolf;Jaime Iranzo;Sergey A. Shmakov

  • Nucleosome mobilization catalysed by the yeast SWI/SNF complex

    Iestyn Whitehouse;Andrew Flaus;Bradley R. Cairns;Malcolm F. White

  • Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity

    Jing Zhang;Christophe Rouillon;Melina Kerou;Judith Reeks

  • The DNA Repair Helicases XPD and FancJ Have Essential Iron-Sulfur Domains

    Jana Rudolf;Vasso Makrantoni;W. John Ingledew;Michael J.R. Stark

  • The Interaction of Alba, a Conserved Archaeal Chromatin Protein, with Sir2 and Its Regulation by Acetylation

    Stephen D. Bell;Catherine H. Botting;Benjamin N. Wardleworth;Stephen P. Jackson

  • Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE).

    Nathanael G. Lintner;Melina Kerou;Susan K. Brumfield;Shirley Graham

  • Structure of the DNA repair helicase XPD.

    Huanting Liu;Jana Rudolf;Kenneth A. Johnson;Stephen A. McMahon

  • Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity.

    Emmanuelle Charpentier;Emmanuelle Charpentier;Hagen Richter;John van der Oost;Malcolm F. White

  • Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

    Derek J. Richard;Emma Bolderson;Liza Cubeddu;Liza Cubeddu;Ross I. M. Wadsworth

  • The major architects of chromatin: architectural proteins in bacteria, archaea and eukaryotes.

    Martijn S. Luijsterburg;Malcolm F. White;Roel van Driel;Remus Th. Dame

  • Structure of the CRISPR interference complex CSM reveals key similarities with cascade

    Christophe Rouillon;Min Zhou;Jing Zhang;Argyris Politis

  • Structure of Alba: an archaeal chromatin protein modulated by acetylation.

    B. N. Wardleworth;R. J. M. Russell;S. D. Bell;G. L. Taylor

  • Archaeal DNA replication and repair.

    Zvi Kelman;Malcolm F White

  • CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems.

    Kira S. Makarova;Vivek Anantharaman;Nick V. Grishin;Eugene V. Koonin

  • Identification and properties of the crenarchaeal single-stranded DNA binding protein from Sulfolobus solfataricus

    Ross I. M. Wadsworth;Malcolm F. White

  • The junction-resolving enzymes

    David M. J. Lilley;Malcolm F. White

  • Insights Into Ssdna Recognition by the Ob Fold from a Structural and Thermodynamic Study of Sulfolobus Ssb Protein

    Iain D. Kerr;Ross I.M. Wadsworth;Liza Cubeddu;Wulf Blankenfeldt

  • An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.

    Januka S Athukoralage;Stephen A McMahon;Changyi Zhang;Sabine Grüschow

  • The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius

    Achim Quaiser;Florence Constantinesco;Malcolm F White;Patrick Forterre

Frequent Co-Authors

James H. Naismith
James H. Naismith Rosalind Franklin Institute
David M.J. Lilley
David M.J. Lilley University of Dundee
Mamuka Kvaratskhelia
Mamuka Kvaratskhelia University of Colorado Denver
Charles S. Bond
Charles S. Bond University of Western Australia
Garry L. Taylor
Garry L. Taylor University of St Andrews
Stephen D. Bell
Stephen D. Bell Indiana University
Kum Kum Khanna
Kum Kum Khanna Mater Research
Mart Krupovic
Mart Krupovic Université Paris Cité
David Prangishvili
David Prangishvili Institut Pasteur
Geoffrey J. Barton
Geoffrey J. Barton University of Dundee

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