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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Molecular Biology

D-Index
122
Citations
41574
World Ranking
245
National Ranking
17

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2016 - Member of the National Academy of Sciences
  • 2000 - Member of Academia Europaea
  • 1995 - Fellow of the Royal Society, United Kingdom

Overview

Stephen C. West is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily spans the broad field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Molecular Biology. Other significant subfields include Oncology, Pathology and Forensic Medicine, Cell Biology, and Electrical and Electronic Engineering.

The scientist's work covers multiple key topics, notably:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • PARP inhibition in cancer therapy
  • Genetic factors in colorectal cancer
  • Microtubule and mitosis dynamics
  • RNA and protein synthesis mechanisms

Stephen C. West has coauthored frequently with the following researchers:

  • Simon J. Boulton
  • Kasper Fugger
  • Radhakrishnan Kanagaraj
  • Graeme Hewitt
  • Luke A. Greenhough

The primary venues where their work has been published include:

  • Nature
  • Molecular Cell
  • Proceedings of the National Academy of Sciences
  • Science
  • Cell Reports

Recent notable publications include:

  • "Repeat expansions confer WRN dependence in microsatellite-unstable cancers," 2020, Nature
  • "Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD," 2020, Molecular Cell
  • "Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors," 2021, Science
  • "POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells," 2022, Molecular Cell
  • "Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor," 2023, Nature

Throughout their career, Stephen C. West has received several distinctions, including:

  • Fellow of the Royal Society, United Kingdom in 1995
  • Member of Academia Europaea in 2000
  • Member of the National Academy of Sciences in 2016

Best Publications

  • Molecular views of recombination proteins and their control

    Stephen C. West

  • DNA interstrand crosslink repair and cancer.

    Andrew J. Deans;Stephen C. West

  • Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

    Peter Baumann;Fiona E Benson;Stephen C West

  • Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

    Adelina A Davies;Jean-Yves Masson;Michael J McIlwraith;Alicja Z Stasiak

  • ROLE OF THE HUMAN RAD51 PROTEIN IN HOMOLOGOUS RECOMBINATION AND DOUBLE-STRANDED-BREAK REPAIR

    Peter Baumann;Stephen C West

  • Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

    Dragana Ahel;Zuzana Hořejší;Nicola Wiechens;Sophie E. Polo

  • XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair.

    Anne O'Donovan;Adelina A. Davies;Jonathan G. Moggs;Stephen C. West

  • The Bloom's syndrome gene product promotes branch migration of Holliday junctions

    Julia K. Karow;Angelos Constantinou;Ji-Liang Li;Stephen C. West

  • Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA.

    F E Benson;A Stasiak;S C West

  • CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

    Fumiko Esashi;Nicole Christ;Julian Gannon;Yilun Liu

  • Processing of recombination intermediates by the RuvABC proteins.

    Stephen C. West

  • Identification of Holliday junction resolvases from humans and yeast

    Stephen C. Y. Ip;Ulrich Rass;Miguel G. Blanco;Helen R. Flynn

  • Synergistic actions of Rad51 and Rad52 in recombination and DNA repair.

    Fiona E. Benson;Peter Baumann;Stephen C. West

  • Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.

    Angelos Constantinou;Madalena Tarsounas;Julia K Karow;Robert M Brosh

  • Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

    Ivan Ahel;Dragana Ahel;Takahiro Matsusaka;Allison J. Clark

  • Enzymes and Molecular Mechanisms of Genetic Recombination

    Stephen C. West

  • Role of RecA protein spiral filaments in genetic recombination.

    Paul Howard-Flanders;Stephen C. West;Andrzej Stasiak

  • The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

    Ivan Ahel;Ulrich Rass;Sherif F. El-Khamisy;Sherif F. El-Khamisy;Sachin Katyal

  • RTEL1 maintains genomic stability by suppressing homologous recombination.

    Louise J. Barber;Jillian L. Youds;Jillian L. Youds;Jordan D. Ward;Michael J. McIlwraith

  • Identification and purification of two distinct complexes containing the five RAD51 paralogs.

    Jean-Yves Masson;Madalena C. Tarsounas;Alicja Z. Stasiak;Andrzej Stasiak

Frequent Co-Authors

Andrzej Stasiak
Andrzej Stasiak University of Lausanne
Paul Howard-Flanders
Paul Howard-Flanders Yale University
Edward H. Egelman
Edward H. Egelman University of Virginia
Ivan Ahel
Ivan Ahel University of Oxford
Simon J. Boulton
Simon J. Boulton The Francis Crick Institute
Xiong Yu
Xiong Yu University of Virginia
Robert G. Lloyd
Robert G. Lloyd University of Nottingham
Neil Q. McDonald
Neil Q. McDonald The Francis Crick Institute
Maria Jasin
Maria Jasin Memorial Sloan Kettering Cancer Center
Ian D. Hickson
Ian D. Hickson University of Copenhagen

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