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Genetics

D-Index
62
Citations
11108
World Ranking
3002
National Ranking
132

Overview

Hiroshi Iwasaki is affiliated with the Tokyo Institute of Technology in Japan, contributing extensively to the fields of biochemistry, genetics, and molecular biology, with additional work spanning medicine. Their research has emphasized molecular biology, surgery, oncology, materials chemistry, and pulmonary and respiratory medicine.

Their main research topics include DNA repair mechanisms, CRISPR and genetic engineering, fungal and yeast genetics research, DNA and nucleic acid chemistry, PARP inhibition in cancer therapy, spinal fractures and fixation techniques, and spine and intervertebral disc pathology.

Frequent publication venues for Hiroshi Iwasaki include:

  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • eLife
  • Anticancer Research

Among their recent papers are:

  • Thermodynamic evaluation of an ammonia-fueled combined-cycle gas turbine process operated under fuel-rich conditions, 2020, Energy
  • Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51, 2020, Nature Communications
  • A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity, 2021, Proceedings of the National Academy of Sciences
  • Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms, 2020, Proceedings of the National Academy of Sciences
  • A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors, 2021, eLife

Hiroshi Iwasaki has collaborated frequently with several researchers, notably:

  • Hideo Tsubouchi
  • Bilge Argunhan
  • Kentaro Ito
  • Takahisa Maki
  • Masayuki Takahashi

The research scope of Hiroshi Iwasaki covers significant areas of molecular biology, including detailed investigation of DNA repair processes and genetic engineering techniques. Their work often appears in journals focused on nucleic acids and molecular genetics, reflecting a consistent engagement with contemporary challenges in biochemical and medical sciences.

Best Publications

  • Large-scale analysis of the yeast genome by transposon tagging and gene disruption

    P. Ross-Macdonald;P. S. R. Coelho;T. Roemer;S. Agarwal

  • RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis

    Hideo Shinagawa;Hiroshi Iwasaki;Takesi Kato;Atsuo Nakata

  • Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

    R. Scott Williams;Gerald E. Dodson;Oliver Limbo;Yoshiki Yamada

  • Atomic structure of the RuvC resolvase: A holliday junction-specific endonuclease from E. coli

    Mariko Ariyoshi;Dmitry G. Vassylyev;Hiroshi Iwasaki;Haruki Nakamura

  • Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure.

    H Iwasaki;M Takahagi;T Shiba;A Nakata

  • Single molecule detection from a large-scale SERS-active Au79Ag21 substrate

    Hongwen Liu;Ling Zhang;Xingyou Lang;Yoshinori Yamaguchi

  • Ferroelectric and optical properties of Pb5Ge3O11 and its isomorphous compound Pb5Ge2SiO11

    Hiroshi Iwasaki;Shintaro Miyazawa;Hideo Koizumi;Kiyomasa Sugii

  • Escherichia coli RuvA and RuvB proteins specifically interact with Holliday junctions and promote branch migration.

    Hiroshi Iwasaki;Masahiko Takahagi;Atsuo Nakata;Hideo Shinagawa

  • Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres

    Kazunori Tomita;Akira Matsuura;Thomas Caspari;Antony M. Carr

  • Establishment of DNA-DNA Interactions by the Cohesin Ring.

    Yasuto Murayama;Catarina P. Samora;Yumiko Kurokawa;Hiroshi Iwasaki

  • Crystal structure of the Holliday junction DNA in complex with a single RuvA tetramer

    Mariko Ariyoshi;Tatsuya Nishino;Hiroshi Iwasaki;Hideo Shinagawa

  • Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks

    Takashi Hishida;Yong Woon Han;Yong Woon Han;Tatsuya Shibata;Yoshino Kubota

  • SOS-inducible DNA repair proteins, RuvA and RuvB, of Escherichia coli: functional interactions between RuvA and RuvB for ATP hydrolysis and renaturation of the cruciform structure in supercoiled DNA.

    Toshikazu Shiba;Hiroshi Iwasaki;Atsuo Nakata;Hideo Shinagawa

  • Processing the holliday junction in homologous recombination

    Hideo Shinagawa;Hiroshi Iwasaki

  • Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast

    Yufuko Akamatsu;Dorota Dziadkowiec;Mitsunori Ikeguchi;Hideo Shinagawa

  • A study on titanium diffusion into LiNbO3 waveguides by electron probe analysis and X-ray diffraction methods

    Kiyomasa Sugii;Masaharu Fukuma;Hiroshi Iwasaki

  • Optical properties in titanium‐diffused LiNbO3 strip waveguides

    Masaharu Fukuma;Juichi Noda;Hiroshi Iwasaki

  • The Swi5-Sfr1 complex stimulates Rhp51/Rad51 - and Dmc1-mediated DNA strand exchange in vitro

    Nami Haruta;Yumiko Kurokawa;Yasuto Murayama;Yufuko Akamatsu;Yufuko Akamatsu

  • Crystal structure of the RuvA-RuvB complex: a structural basis for the Holliday junction migrating motor machinery.

    Kazuhiro Yamada;Tomoko Miyata;Daisuke Tsuchiya;Takuji Oyama

  • The Escherichia coli polB gene, which encodes DNA polymerase II, is regulated by the SOS system.

    H Iwasaki;A Nakata;G C Walker;H Shinagawa

Frequent Co-Authors

Hideo Shinagawa
Hideo Shinagawa BioAcademia
Atsuo Nakata
Atsuo Nakata Osaka University
Tatsuo Yoshinobu
Tatsuo Yoshinobu Tohoku University
Masayuki Takahashi
Masayuki Takahashi Tokyo Institute of Technology
Kosuke Morikawa
Kosuke Morikawa Kyoto University
Toshiyuki Shimizu
Toshiyuki Shimizu University of Tokyo
Yoshizumi Ishino
Yoshizumi Ishino Kyushu University
Antony M. Carr
Antony M. Carr University of Sussex
Qi-Kun Xue
Qi-Kun Xue Southern University of Science and Technology
Mingwei Chen
Mingwei Chen Southern University of Science and Technology

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