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Genetics

D-Index
103
Citations
33562
World Ranking
685
National Ranking
348

Research.com Recognitions

  • 2007 - Member of the National Academy of Sciences
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stephen C. Kowalczykowski is affiliated with the University of California, Davis, in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Genetics, Radiology, Nuclear Medicine and Imaging, Biomedical Engineering, and Molecular Medicine.

Their work addresses several main topics, including:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Bacterial Genetics and Biotechnology
  • BRCA gene mutations in cancer
  • Photosynthetic Processes and Mechanisms
  • Monoclonal and Polyclonal Antibodies Research
  • Microfluidic and Capillary Electrophoresis Applications

The scientist has contributed to numerous publications in notable venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nucleic Acids Research
  • UNC Libraries
  • Biophysical Reports

Recent papers include:

  • BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA, 2023, Proceedings of the National Academy of Sciences
  • Direct visualization of translesion DNA synthesis polymerase IV at the replisome, 2022, Proceedings of the National Academy of Sciences
  • Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae, 2023, Nucleic Acids Research
  • Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition, 2024, Nucleic Acids Research
  • Charles M. Radding: A love of science and art, 2021, Proceedings of the National Academy of Sciences

The researcher collaborates frequently with several co-authors, including:

  • Neville S. Gilhooly
  • Jason C. Bell
  • Christopher Dombrowski
  • Jody L. Plank
  • Ryan B. Jensen

Stephen C. Kowalczykowski has been recognized with multiple awards, including membership in the National Academy of Sciences since 2007, fellowship in the American Academy of Arts and Sciences since 2005, and fellowship in the American Association for the Advancement of Science (AAAS) since 2001.

Best Publications

  • Biochemistry of homologous recombination in Escherichia coli.

    S C Kowalczykowski;D A Dixon;A K Eggleston;S D Lauder

  • Initiation of genetic recombination and recombination-dependent replication.

    Stephen C Kowalczykowski

  • BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

    Amitabh V. Nimonkar;Jochen Genschel;Eri Kinoshita;Piotr Polaczek

  • Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

    James H. New;Tomohiko Sugiyama;Elena Zaitseva;Stephen C. Kowalczykowski

  • Purified human BRCA2 stimulates RAD51-mediated recombination

    Ryan B. Jensen;Aura Carreira;Stephen C. Kowalczykowski

  • The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

    Xavier Veaute;Josette Jeusset;Christine Soustelle;Stephen C. Kowalczykowski

  • RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks

    Mark S. Dillingham;Stephen C. Kowalczykowski

  • DNA STRAND EXCHANGE PROTEINS: A BIOCHEMICAL AND PHYSICAL COMPARISON

    Piero R. Bianco;Robert B. Tracy;Stephen C. Kowalczykowski

  • Pif1 family helicases suppress genome instability at G-quadruplex motifs

    Katrin Paeschke;Katrin Paeschke;Matthew L. Bochman;P. Daniela Garcia;Petr Cejka;Petr Cejka

  • An Overview of the Molecular Mechanisms of Recombinational DNA Repair

    Stephen C. Kowalczykowski

  • RecFOR Proteins Load RecA Protein onto Gapped DNA to Accelerate DNA Strand Exchange: A Universal Step of Recombinational Repair

    Katsumi Morimatsu;Stephen C Kowalczykowski

  • DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2

    Petr Cejka;Elda Cannavo;Piotr Polaczek;Taro Masuda-Sasa

  • Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks

    Martin R. Singleton;Mark S. Dillingham;Martin Gaudier;Stephen C. Kowalczykowski

  • Homologous Pairing and DNA Strand-Exchange Proteins

    Stephen C. Kowalczykowski;Angela K. Eggleston

  • DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA.

    Tomohiko Sugiyama;James H. New;Stephen C. Kowalczykowski

  • Processive translocation and DNA unwinding by individual RecBCD enzyme molecules

    Piero R. Bianco;Laurence R. Brewer;Michele Corzett;Rod Balhorn

  • A Single-stranded DNA-binding Protein Is Needed for Efficient Presynaptic Complex Formation by the Saccharomyces cerevisiae Rad51 Protein

    Tomohiko Sugiyama;Elena M. Zaitseva;Stephen C. Kowalczykowski

  • The Translocating RecBCD Enzyme Stimulates Recombination by Directing RecA Protein onto ssDNA in a χ-Regulated Manner

    Daniel G Anderson;Stephen C Kowalczykowski

  • Interaction of recA protein with single-stranded DNA. Quantitative aspects of binding affinity modulation by nucleotide cofactors.

    Joseph P. Menetski;Stephen C. Kowalczykowski

  • RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.

    Frank G. Harmon;Stephen C. Kowalczykowski

Frequent Co-Authors

Alexander V. Mazin
Alexander V. Mazin Drexel University
Mark S. Dillingham
Mark S. Dillingham University of Bristol
Peter H. von Hippel
Peter H. von Hippel University of Oregon
Frédéric Chédin
Frédéric Chédin University of California, Davis
Wolf Dietrich Heyer
Wolf Dietrich Heyer University of California, Davis
E. Morton Bradbury
E. Morton Bradbury University of California, Davis
Dale B. Wigley
Dale B. Wigley Imperial College London
Andrzej Stasiak
Andrzej Stasiak University of Lausanne
Stephen J. Elledge
Stephen J. Elledge Harvard University

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