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Molecular Biology

D-Index
43
Citations
8120
World Ranking
2970
National Ranking
230

Overview

Mark S. Dillingham is affiliated with the University of Bristol in the United Kingdom. Their research primarily focuses on the field of Biochemistry, Genetics, and Molecular Biology, with notable contributions to Molecular Biology, Genetics, Ecology, Pulmonary and Respiratory Medicine, and Cancer Research.

The scientist's main topics of work include:

  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • Bacterial Genetics and Biotechnology
  • CRISPR and Genetic Engineering
  • Bacteriophages and microbial interactions
  • RNA and protein synthesis mechanisms
  • Mitochondrial Function and Pathology

Mark S. Dillingham has published extensively, often collaborating with several frequent co-authors including Oliver J. Wilkinson, Fernando Moreno-Herrero, Clara Aicart-Ramos, Sara de Bragança, and Francisco de Asís Balaguer.

Recent papers include:

  • CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS, 2021, eLife
  • Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus, 2022, Nucleic Acids Research
  • Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA, 2022, Proceedings of the National Academy of Sciences
  • Refined measurement of SecA-driven protein secretion reveals that translocation is indirectly coupled to ATP turnover, 2020, Proceedings of the National Academy of Sciences
  • Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub, 2022, eLife

Their publications are often found in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Nucleic Acids Research
  • Proceedings of the National Academy of Sciences
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Structure and mechanism of helicases and nucleic acid translocases.

    Martin R Singleton;Mark S Dillingham;Dale B Wigley

  • Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.

    Sameer S Velankar;Panos Soultanas;Mark S Dillingham;Hosahalli S Subramanya

  • RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks

    Mark S. Dillingham;Stephen C. Kowalczykowski

  • Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks

    Martin R. Singleton;Mark S. Dillingham;Martin Gaudier;Stephen C. Kowalczykowski

  • RecBCD enzyme is a bipolar DNA helicase

    Mark S Dillingham;Maria Spies;Stephen C Kowalczykowski

  • Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed.

    Mark S. Dillingham;Dale B. Wigley;Martin R. Webb

  • A Molecular Throttle: The Recombination Hotspot χ Controls DNA Translocation by the RecBCD Helicase

    Maria Spies;Piero R. Bianco;Mark S. Dillingham;Naofumi Handa

  • Rep Provides a Second Motor at the Replisome to Promote Duplication of Protein-Bound DNA

    Colin P. Guy;John Atkinson;Milind K. Gupta;Akeel A. Mahdi

  • Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.

    Panos Soultanas;Mark S. Dillingham;Paul Wiley;Martin R. Webb

  • DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase

    Panos Soultanas;Mark S Dillingham;Sameer S Velankar;Dale B Wigley

  • Direct measurement of single-stranded DNA translocation by PcrA helicase using the fluorescent base analogue 2-aminopurine.

    Mark S Dillingham;Dale B Wigley;Martin R Webb

  • Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase

    Mark S. Dillingham;Panos Soultanas;Paul Wiley;Martin R. Webb

  • Site-directed mutagenesis of motif III in PcrA helicase reveals a role in coupling ATP hydrolysis to strand separation

    Mark S. Dillingham;Panos Soultanas;Dale B. Wigley

  • An Iron-Sulfur Cluster Is Essential for the Binding of Broken DNA by AddAB-type Helicase-Nucleases

    Joseph T. P. Yeeles;Richard Cammack;Mark S. Dillingham

  • The conflict between DNA replication and transcription

    Peter McGlynn;Nigel J. Savery;Mark S. Dillingham

  • The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

    Gemma Lm Fisher;César L. Pastrana;Victoria A. Higman;Alan Koh

  • The processing of double-stranded DNA breaks for recombinational repair by helicase–nuclease complexes

    Joseph T P Yeeles;Mark S Dillingham

  • Repercussions of DNA tracking by the type IC restriction endonuclease EcoR124I on linear, circular and catenated substrates

    Mark D Szczelkun;Mark S Dillingham;P Janscak;K Firman

  • Plasmid replication initiator protein RepD increases the processivity of PcrA DNA helicase

    Panos Soultanas;Mark S. Dillingham;Fotios Papadopoulos;Simon E. V. Phillips

  • Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase

    Mark S Dillingham;D B Wigley;M R Webb

Frequent Co-Authors

Dale B. Wigley
Dale B. Wigley Imperial College London
Stephen C. Kowalczykowski
Stephen C. Kowalczykowski University of California, Davis
Frank Sobott
Frank Sobott University of Leeds
Matthew P. Crump
Matthew P. Crump University of Bristol
Robert G. Lloyd
Robert G. Lloyd University of Nottingham
Sameer Velankar
Sameer Velankar European Bioinformatics Institute
Simon E. V. Phillips
Simon E. V. Phillips University of Oxford
Richard W. Titball
Richard W. Titball University of Exeter
Ichizo Kobayashi
Ichizo Kobayashi University of Tokyo
Clive J. Roberts
Clive J. Roberts University of Nottingham

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