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Minoru Takata

Minoru Takata

D-Index & Metrics

Molecular Biology

D-Index
86
Citations
22059
World Ranking
833
National Ranking
63

Overview

Minoru Takata is affiliated with Kyoto University in Japan and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on Medicine. Their research primarily addresses mechanisms of DNA repair, genetic engineering, and cancer-related therapeutic strategies.

The scientist's work spans multiple subfields including Molecular Biology, Oncology, Cancer Research, Hematology, and Genetics. Central topics in their research include DNA Repair Mechanisms, CRISPR and Genetic Engineering, PARP inhibition in cancer therapy, Carcinogens and Genotoxicity Assessment, Acute Myeloid Leukemia Research, Cancer therapeutics and mechanisms, as well as Acute Lymphoblastic Leukemia research.

Minoru Takata has published in a variety of scientific journals, with frequent appearances in:

  • Blood
  • DNA repair
  • PubMed
  • Molecular Cell
  • Genes to Cells

Their recent papers include:

  • Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans (2020) - Molecular Cell
  • Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency (2021) - Blood
  • USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9 (2020) - Oncogenesis
  • Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress (2021) - Nature Structural & Molecular Biology
  • SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells (2020) - Blood

Frequent collaborators in their research include Anfeng Mu, Yusuke Okamoto, Y Katsuki, Seishi Ogawa, and Asuka Hira.

Best Publications

  • Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

    Minoru Takata;Masao S. Sasaki;Eiichiro Sonoda;Ciaran Morrison

  • Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death

    Eiichiro Sonoda;Masao S. Sasaki;Jean Marie Buerstedde;Olga Bezzubova

  • Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

    M. Takata;H. Sabe;A. Hata;T. Inazu

  • Chromosome Instability and Defective Recombinational Repair in Knockout Mutants of the Five Rad51 Paralogs

    Minoru Takata;Masao S. Sasaki;Seiji Tachiiri;Toru Fukushima

  • A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

    M Takata;T Kurosaki

  • Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells.

    Eiichiro Sonoda;Masao S. Sasaki;Ciaran Morrison;Yuko Yamaguchi-Iwai

  • Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5‐trisphosphate receptors in signal transduction through the B‐cell antigen receptor

    Hitoshi Sugawara;Mari Kurosaki;Minoru Takata;Tomohiro Kurosaki

  • Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

    T Kurosaki;M Takata;Y Yamanashi;T Inazu

  • Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

    Hiroshi Tauchi;Junya Kobayashi;Ken ichi Morishima;Dik C. Van Gent

  • Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

    Yuko Yamaguchi-Iwai;Eiichiro Sonoda;Masao S. Sasaki;Ciaran Morrison

  • The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair

    Minoru Takata;Masao S. Sasaki;Eiichiro Sonoda;Toru Fukushima

  • Homologous Recombination, but Not DNA Repair, Is Reduced in Vertebrate Cells Deficient in RAD52

    Yuko Yamaguchi-Iwai;Eiichiro Sonoda;Jean Marie Buerstedde;Olga Bezzubova

  • FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.

    Masamichi Ishiai;Hiroyuki Kitao;Hiroyuki Kitao;Hiroyuki Kitao;Agata Smogorzewska;Junya Tomida

  • Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

    Julian E. Sale;Daniella M. Calandrini;Minoru Takata;Shunichi Takeda

  • NADPH Oxidase 4 Contributes to Transformation Phenotype of Melanoma Cells by Regulating G2-M Cell Cycle Progression

    Maki Yamaura;Junji Mitsushita;Shuichi Furuta;Yukiko Kiniwa

  • Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.

    M Takata;Y Homma;T Kurosaki

  • BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells.

    Fatih M. Uckun;Kevin G. Waddick;Sandeep Mahajan;Xiao Jun

  • Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates

    Eiichiro Sonoda;Takashi Okada;Guang Yu Zhao;Satoshi Tateishi

  • Emergence of Epidermal Growth Factor Receptor T790M Mutation during Chronic Exposure to Gefitinib in a Non-Small Cell Lung Cancer Cell Line

    Atsuko Ogino;Hiroyuki Kitao;Seiki Hirano;Seiki Hirano;Akiko Uchida

  • Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

    Kimiyo N. Yamamoto;Shunsuke Kobayashi;Masataka Tsuda;Hitoshi Kurumizaka

Frequent Co-Authors

Shunichi Takeda
Shunichi Takeda Shenzhen University
Masamichi Ishiai
Masamichi Ishiai Kyoto University
Eiichiro Sonoda
Eiichiro Sonoda Kyoto University
Hitoshi Kurumizaka
Hitoshi Kurumizaka University of Tokyo
Seishi Ogawa
Seishi Ogawa Kyoto University
Seiji Kojima
Seiji Kojima Nagoya University
Akifumi Takaori-Kondo
Akifumi Takaori-Kondo Kyoto University
Etsuro Ito
Etsuro Ito Hirosaki University
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University

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