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Genetics

D-Index
48
Citations
10067
World Ranking
4053
National Ranking
462

Overview

Julian E. Sale is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, with a specific focus on Molecular Biology. Additional subfields of interest include Cancer Research, Oncology, Genetics, and Infectious Diseases.

The scientist's work covers several important topics, among which are:

  • DNA Repair Mechanisms
  • Cancer Genomics and Diagnostics
  • Genomics and Chromatin Dynamics
  • CRISPR and Genetic Engineering
  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA and protein synthesis mechanisms

Julian E. Sale has contributed to multiple peer-reviewed journals, frequently publishing in the following venues:

  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature
  • UNC Libraries

Their recent notable publications include:

  • Mechanisms of APOBEC3 mutagenesis in human cancer cells, 2022, Nature
  • Timeless couples G-quadruplex detection with processing by DDX 11 helicase during DNA replication, 2020, The EMBO Journal
  • DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats, 2020, Genome Biology
  • Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation, 2022, Nucleic Acids Research
  • In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding, 2022, PLoS Pathogens

The scientist has collaborated frequently with several researchers, including:

  • Guillaume Guilbaud
  • Pierre Murat
  • Saša Šviković
  • Alastair Crisp
  • Christopher Mellor

Best Publications

  • Clock-like mutational processes in human somatic cells

    Ludmil B Alexandrov;Philip H Jones;Philip H Jones;David C Wedge;Julian E Sale

  • Y-family DNA polymerases and their role in tolerance of cellular DNA damage

    Julian E. Sale;Alan R. Lehmann;Roger Woodgate

  • TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

    Julian E Sale;Michael S Neuberger

  • Epigenetic Instability due to Defective Replication of Structured DNA

    Peter Sarkies;Charlie Reams;Laura J. Simpson;Julian E. Sale

  • AID is essential for immunoglobulin V gene conversion in a cultured B cell line

    Reuben S. Harris;Julian E. Sale;Svend K. Petersen-Mahrt;Michael S. Neuberger

  • PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

    Charlotte E. Edmunds;Laura J. Simpson;Julian E. Sale

  • Translesion DNA Synthesis and Mutagenesis in Eukaryotes

    Julian E. Sale

  • The topography of mutational processes in breast cancer genomes

    Sandro Morganella;Ludmil B. Alexandrov;Dominik Glodzik;Xueqing Zou

  • Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

    Julian E. Sale;Daniella M. Calandrini;Minoru Takata;Shunichi Takeda

  • Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line

    Laura J. Simpson;Julian E. Sale

  • FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

    Peter Sarkies;Pierre Murat;Lara G. Phillips;K.J. Patel

  • Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

    Jutta Zimmer;Eliana M.C. Tacconi;Cecilia Folio;Sophie Badie

  • Deubiquitination of FANCD2 is required for DNA crosslink repair.

    Vibe H. Oestergaard;Frederic Langevin;Hendrik J. Kuiken;Paul Pace

  • Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde

    John R. Ridpath;Ayumi Nakamura;Ayumi Nakamura;Keizo Tano;April M. Luke

  • PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

    Davide Schiavone;Stanislaw K. Jozwiakowski;Marina Romanello;Guillaume Guilbaud

  • Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.

    Anna-Laura Ross;Laura J. Simpson;Julian E. Sale

  • PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

    Annabel Quinet;Stephanie Tirman;Stephanie Tirman;Jessica Jackson;Saša Šviković

  • Replication of G Quadruplex DNA.

    Leticia Koch Lerner;Julian E. Sale

  • Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines.

    Sarah J. Cumbers;Gareth T. Williams;Sarah L. Davies;Richard L. Grenfell

  • Determinants of G quadruplex‐induced epigenetic instability in REV1‐deficient cells

    Davide Schiavone;Guillaume Guilbaud;Pierre Murat;Charikleia Papadopoulou

Frequent Co-Authors

Shunichi Takeda
Shunichi Takeda Shenzhen University
Eiichiro Sonoda
Eiichiro Sonoda Kyoto University
Minoru Takata
Minoru Takata Kyoto University
Shigenori Iwai
Shigenori Iwai Osaka University
Michael S. Neuberger
Michael S. Neuberger MRC Laboratory of Molecular Biology
Facundo D. Batista
Facundo D. Batista Harvard Medical School
Toshiki Tsurimoto
Toshiki Tsurimoto Kyushu University
Serena Nik-Zainal
Serena Nik-Zainal University of Cambridge
Alan R. Lehmann
Alan R. Lehmann University of Sussex
Aidan J. Doherty
Aidan J. Doherty University of Sussex

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