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D-Index
63
Citations
14547
World Ranking
2890
National Ranking
1263

Overview

Nancy Maizels is a researcher affiliated with the University of Washington in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Oncology, and Genetics. The scientist's work also intersects with Molecular Medicine and Materials Chemistry.

Their research contributions are mainly concentrated on the following topics:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Cancer therapeutics and mechanisms
  • Neutropenia and Cancer Infections
  • Cancer-related Molecular Pathways
  • Bacterial Genetics and Biotechnology
  • Antibiotic Resistance in Bacteria

Nancy Maizels has published extensively, with several recent papers illustrating ongoing work in DNA repair and mutagenesis. Selected publications include:

  • "POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks," 2020, Proceedings of the National Academy of Sciences
  • "Topoisomerase Assays," 2021, Current Protocols
  • "The 'adductome': A limited repertoire of adducted proteins in human cells," 2020, DNA Repair
  • "Isolation and detection of DNA-protein crosslinks in mammalian cells," 2023, Nucleic Acids Research
  • "Pathways and signatures of mutagenesis at targeted DNA nicks," 2021, PLoS Genetics

Their frequent collaborators include Kostantin Kiianitsa, Yinbo Zhang, Luther Davis, D. K. Sinha, and David R. Sherman. Collaboration with these coauthors reflects a research network engaged in areas related to DNA repair, genetic engineering, and molecular biology.

Major venues where Nancy Maizels has published are:

  • DNA Repair
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Current Protocols
  • Nucleic Acids Research

The scientist's work also addresses mutations and mechanisms involved in cancer and infection, highlighting interdisciplinary themes bridging molecular biology with medical research. This involves studies on cancer therapeutics, molecular pathways relevant to oncogenesis, and bacterial genetics related to antibiotic resistance.

Best Publications

  • The Bloom’s Syndrome Helicase Unwinds G4 DNA

    Hui Sun;Julia K. Karow;Ian D. Hickson;Nancy Maizels

  • Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA

    Michelle L. Duquette;Priya Handa;Jack A. Vincent;Andrew F. Taylor

  • Gene function correlates with potential for G4 DNA formation in the human genome

    Johanna Eddy;Nancy Maizels

  • Dynamic roles for G4 DNA in the biology of eukaryotic cells

    Nancy Maizels

  • The G4 genome.

    Nancy Maizels;Lucas T. Gray

  • tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: implications for the origin of protein synthesis.

    Alan M. Weiner;Nancy Maizels

  • HuR binding to cytoplasmic mRNA is perturbed by heat shock

    Imed Eddine Gallouzi;Christopher M. Brennan;Myrna G. Stenberg;Maurice S. Swanson

  • Immunoglobulin gene diversification

    Nancy Maizels

  • Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

    Johanna Eddy;Nancy Maizels

  • G4‐associated human diseases

    Nancy Maizels

  • High affinity interactions of nucleolin with G-G-paired rDNA.

    L. A. Hanakahi;Hui Sun;Nancy Maizels

  • The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs

    Hui Sun;Richard J. Bennett;Nancy Maizels

  • Phylogeny from function: evidence from the molecular fossil record that tRNA originated in replication, not translation

    Nancy Maizels;Alan M. Weiner

  • G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition

    Michael D. Huber;Damian C. Lee;Nancy Maizels

  • Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair

    Luther Davis;Nancy Maizels

  • G4 DNA Binding by LR1 and Its Subunits, Nucleolin and hnRNP D, A Role for G-G pairing in Immunoglobulin Switch Recombination

    Laurie A. Dempsey;Hui Sun;L. A. Hanakahi;Nancy Maizels

  • CCA-adding enzymes and poly(A) polymerases are all members of the same nucleotidyltransferase superfamily: characterization of the CCA-adding enzyme from the archaeal hyperthermophile Sulfolobus shibatae.

    Dongxian Yue;Nancy Maizels;Alan M. Weiner

  • G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

    Lucas T Gray;Aarthy C Vallur;Johanna Eddy;Nancy Maizels

  • AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation.

    Michelle L Duquette;Phuong Pham;Myron F Goodman;Nancy Maizels

  • Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

    Audrey McConnell Smith;Ryo Takeuchi;Stefan Pellenz;Luther Davis

Frequent Co-Authors

Alan M. Weiner
Alan M. Weiner University of Washington
Raymond J. Monnat
Raymond J. Monnat University of Washington
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
Marie-Paule Teulade-Fichou
Marie-Paule Teulade-Fichou University of Paris-Saclay
William M. Grady
William M. Grady Fred Hutchinson Cancer Research Center
Joan A. Steitz
Joan A. Steitz Yale University
Junko Oshima
Junko Oshima University of Washington
Reuben S. Harris
Reuben S. Harris The University of Texas Health Science Center at San Antonio
Michael Ashburner
Michael Ashburner University of Cambridge
Ian D. Hickson
Ian D. Hickson University of Copenhagen

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