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Biology and Biochemistry

D-Index
65
Citations
10599
World Ranking
9418
National Ranking
88

Overview

Mark Pines is affiliated with the Hebrew University of Jerusalem in Israel and has contributed to research spanning biochemistry, genetics, molecular biology, and medicine. Their work integrates several subfields including molecular biology, biomedical engineering, cardiology and cardiovascular medicine, polymers and plastics, and genetics.

The scientist's research focuses mainly on muscle physiology and disorders, with additional emphasis on advanced sensor and energy harvesting materials, cardiomyopathy and myosin studies, conducting polymers and applications, as well as neurogenetic and muscular disorders research.

Recent publications include studies in the following venues: Neuromuscular Disorders and the International Journal of Molecular Sciences.

  • Early pathological signs in young dysf mice are improved by halofuginone (2020, Neuromuscular Disorders)
  • Differential Effects of Halofuginone Enantiomers on Muscle Fibrosis and Histopathology in Duchenne Muscular Dystrophy (2021, International Journal of Molecular Sciences)

Mark Pines frequently collaborates with Olga Genin and Orna Halevy, each contributing to two joint publications. Other coauthors include Hila Barzilai-Tutsch, Sharon Mordechay, and Shaun Smullen.

  • Olga Genin
  • Orna Halevy
  • Hila Barzilai-Tutsch
  • Sharon Mordechay
  • Shaun Smullen

The combination of biomedical engineering and molecular biology within their research supports interdisciplinary approaches to studying muscle-related diseases, including Duchenne muscular dystrophy, and the roles of specific compounds such as halofuginone in muscle pathology.

Best Publications

  • The IIIc alternative of Fgfr2 is a positive regulator of bone formation

    Vereragavan P. Eswarakumar;Efrat Monsonego-Ornan;Mark Pines;Ileana Antonopoulou

  • A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3

    Yingcai Wang;Michal K. Spatz;Karuppiah Kannan;Hovhannisyan Hayk

  • Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma.

    Mark Pines;David Snyder;Shai Yarkoni;Arnon Nagler

  • Halofuginone: A Novel Antifibrotic Therapy

    M. Pines;Arnon Nagler

  • Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats.

    Rafael Bruck;Olga Genina;Hussein Aeed;Rosaly Alexiev

  • Prevention of liver cirrhosis in rats by curcumin.

    Rafael Bruck;Michal Ashkenazi;Sigal Weiss;Ilana Goldiner

  • Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.

    Yehiel Zick;Ronit Sagi-Eisenberg;Mark Pines;Peter Gierschik

  • Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain

    Peter Gierschik;Graeme Milligan;Mark Pines;Paul Goldsmith

  • Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.

    P Gierschik;J Falloon;G Milligan;M Pines

  • Halofuginone: an inhibitor of collagen type I synthesis.

    I. Granot;O. Halevy;S. Hurwitz;M. Pines

  • Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis

    Mark Pines;Viktor Knopov;Olga Genina;Irina Lavelin

  • Involvement of osteopontin in egg shell formation in the laying chicken.

    Mark Pines;Viktor Knopov;Arie Bar

  • Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone.

    Tidhar Turgeman;Yosey Hagai;Kyla Huebner;Davinder S. Jassal

  • Halofuginone: a potent inhibitor of critical steps in angiogenesis progression

    Michael Elkin;Hua-Quan Miao;Arnon Nagler;Elena Aingorn

  • New Insight in Eggshell Formation

    I. Lavelin;N. Meiri;M. Pines

  • Halofuginone — The Multifaceted Molecule

    Mark Pines;Itai Spector

  • Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone

    Orna Halevy;Arnon Nagler;Francesca Levi-Schaffer;Olga Genina

  • Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone

    Kyla D. Huebner;Davinder S. Jassal;Orna Halevy;Mark Pines

  • Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone

    Michael Elkin;Ilana Ariel;Hua Quan Miao;Arnon Nagler

  • A common pathway mediated through Toll-like receptors leads to T- and natural killer–cell immunosuppression

    Ilan Vaknin;Liora Blinder;Lynn Wang;Roi Gazit

Frequent Co-Authors

Arnon Nagler
Arnon Nagler Sheba Medical Center
Orna Halevy
Orna Halevy Hebrew University of Jerusalem
Shmuel Hurwitz
Shmuel Hurwitz Agricultural Research Organization
Israel Vlodavsky
Israel Vlodavsky Technion – Israel Institute of Technology
Shimon Slavin
Shimon Slavin Hebrew University of Jerusalem
Arieh Gertler
Arieh Gertler Hebrew University of Jerusalem
Norifumi Kawada
Norifumi Kawada Osaka Metropolitan University
Francesca Levi-Schaffer
Francesca Levi-Schaffer Hebrew University of Jerusalem
Katsutoshi Yoshizato
Katsutoshi Yoshizato Osaka Metropolitan University
I. Plavnik
I. Plavnik Agricultural Research Organization

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