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Immunology

D-Index
69
Citations
20620
World Ranking
2485
National Ranking
1191

Overview

Chaim O. Jacob is affiliated with the University of Southern California in the United States. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with subfields that include Immunology, Rheumatology, Nephrology, Infectious Diseases, and Neurology.

The main topics of Jacob's work cover Systemic Lupus Erythematosus Research, T-cell and B-cell Immunology, Renal Diseases and Glomerulopathies, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Immune Response and Inflammation, Immune Cell Function and Interaction, and COVID-19 Clinical Research Studies.

Jacob's recent papers include the following:

  • On the genetics and immunopathogenesis of COVID-19, 2020, Clinical Immunology
  • Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis, 2020, JCI Insight
  • Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice, 2020, Journal of Translational Autoimmunity
  • New Endothelial Mechanisms in Glomerular (Patho)biology and Proteinuria Development Captured by Intravital Multiphoton Imaging, 2021, Frontiers in Medicine
  • Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner, 2024, Journal of Autoimmunity

The scientist regularly publishes in venues such as:

  • JCI Insight
  • Clinical Immunology
  • Journal of Translational Autoimmunity
  • Frontiers in Medicine
  • Journal of Autoimmunity

Noted frequent co-authors of Jacob include:

  • Ning Yu
  • Georgina Gyarmati
  • János Peti-Peterdi
  • Tâm D. Quách
  • Catherine M.M. Diadhiou

The scientist's work contributes to understanding immune system mechanisms, particularly in autoimmune diseases like systemic lupus erythematosus and related renal pathologies. Their research on COVID-19 addresses genetic and immunopathogenic factors, reflecting diversification into infectious disease studies within the immunological domain.

Best Publications

  • Human polymorphism at microRNAs and microRNA target sites.

    Liuqing Yang;Chunru Lin;Chunyu Jin;Joy C. Yang

  • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

    John B. Harley;John B. Harley;John B. Harley;Marta E. Alarcón-Riquelme;Lindsey A. Criswell;Chaim O. Jacob

  • Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

    Chaim O. Jacob;Zdenka Fronek;Gail D. Lewis;May Koo

  • A molecular basis for MHC class II--associated autoimmunity

    J A Todd;H Acha-Orbea;J I Bell;N Chao

  • Evidence for the involvement of interleukin 6 in experimental cancer cachexia.

    G Strassmann;M Fong;J S Kenney;C O Jacob

  • Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

    Chaim O. Jacob;Hugh O. McDevitt

  • In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

    Chaim O. Jacob;P. H. Van Der Meide;Hugh O. Mcdevitt

  • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

    Chaim O. Jacob;Sadakazu Aiso;Sara A. Michie;Hugh O. Mcdevitt

  • Transancestral mapping and genetic load in systemic lupus erythematosus

    Carl D. Langefeld;Hannah C. Ainsworth;Deborah S. Cunninghame Graham;Jennifer A. Kelly

  • Genome-Wide Screen for Systemic Lupus Erythematosus Susceptibility Genes in Multiplex Families

    Shai R;Quismorio Fp;Li L;Kwon Oj

  • Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

    B. Namjou;P. H. Kothari;J. A. Kelly;S. B. Glenn

  • Immune response to cholera toxin epitope inserted in Salmonella flagellin.

    Salete M. C. Newton;Chaim O. Jacob;Bruce A. D. Stocker

  • Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

    Indra Adrianto;Feng Wen;Amanda Templeton;Graham B. Wiley

  • Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

    Chaim O. Jacob;Jiankun Zhu;Don L. Armstrong;Don L. Armstrong;Mei Yan

  • Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

    Jian Zhao;Hui Wu;Melanie Khosravi;Huijuan Cui

  • Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

    Sharon A. Chung;Kimberly E. Taylor;Robert R. Graham;Joanne Nititham

  • Methods for determining genetic predisposition to autoimmune diseases by genotyping apoptotic genes

    Chaim O. Jacob

  • Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages.

    Taku Kambayashi;Chaim O. Jacob;David Zhou;Nachman Mazurek

  • Synergistic effect between IL‐10 and bcl‐2 genotypes in determining susceptibility to systemic lupus erythematosus

    Ruty Mehrian;Francisco P. Quismorio;Gideon Strassmann;Mary M. Stimmler

  • A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap

    Paula S. Ramos;Lindsey A. Criswell;Kathy L. Moser;Mary E. Comeau

Frequent Co-Authors

John B. Harley
John B. Harley United States Department of Veterans Affairs
Marta E. Alarcón-Riquelme
Marta E. Alarcón-Riquelme University of Granada
Judith A. James
Judith A. James Oklahoma Medical Research Foundation
Kenneth M. Kaufman
Kenneth M. Kaufman Cincinnati Children's Hospital Medical Center
Patrick M. Gaffney
Patrick M. Gaffney Oklahoma Medical Research Foundation
Carl D. Langefeld
Carl D. Langefeld Wake Forest University
Robert P. Kimberly
Robert P. Kimberly University of Alabama at Birmingham
Timothy J. Vyse
Timothy J. Vyse King's College London
R. Hal Scofield
R. Hal Scofield University of Oklahoma Health Sciences Center
Betty P. Tsao
Betty P. Tsao University of California, Los Angeles

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