World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
11600
World Ranking
17902
National Ranking
7326

Overview

F. Brad Johnson is affiliated with the University of Pennsylvania in the United States and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Their subfields of focus include Molecular Biology, Physiology, Pulmonary and Respiratory Medicine, Oncology, and Epidemiology. The scientist's work covers various topics with notable emphasis on telomeres, telomerase, and senescence, which represent a significant portion of their research output.

Their research portfolio includes investigations into advanced biosensing and bioanalysis techniques, neonatal respiratory health, pluripotent stem cells, Wnt/β-catenin signaling pathways in development and cancer, cancer-related gene regulation, and epigenetics and DNA methylation.

F. Brad Johnson has contributed to multiple recent papers, including:

  • SLC25A51 is a mammalian mitochondrial NAD+ transporter (2020, Nature)
  • TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity (2021, Scientific Reports)
  • Fundamentals of G-quadruplex biology (2020, Annual reports in medicinal chemistry)
  • APC and P53 mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer (2023, Gut)
  • Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia (2021, Nature Medicine)

Their frequent co-authors include Katrina N. Estep, Christopher J. Lengner, Rafael Fernández, Zvi Cramer, and Joshua H. Rhoades. Collaboration with these researchers appears regularly in publications.

F. Brad Johnson's work is published across several venues, with multiple papers appearing in bioRxiv (Cold Spring Harbor Laboratory), and others in Nature, Scientific Reports, Gut, and Nature Medicine. These outlets reflect a broad engagement with both preprint and peer-reviewed publishing platforms.

Best Publications

  • Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

    Joseph A. Fraietta;Simon F. Lacey;Elena J. Orlando;Iulian Pruteanu-Malinici

  • Molecular Biology of Aging

    F.Brad Johnson;David A Sinclair;Leonard Guarente

  • Histone H4 lysine-16 acetylation regulates cellular lifespan

    Weiwei Dang;Kristan K. Steffen;Rocco Perry;Jean A. Dorsey

  • Detection of G-quadruplex DNA in mammalian cells

    Alexander Henderson;Yuliang Wu;Yu Chuan Huang;Elizabeth A. Chavez

  • Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

    Raffaella Nativio;Greg Donahue;Amit Berson;Yemin Lan

  • Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

    Matthew J. Frigault;Jihyun Lee;Maria Ciocca Basil;Carmine Carpenito

  • The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

    F. Brad Johnson;F. Brad Johnson;F. Brad Johnson;Robert A. Marciniak;Robert A. Marciniak;Mitch McVey;Sheila A. Stewart

  • Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae

    Steve G. Hershman;Qijun Chen;Julia Y. Lee;Marina L. Kozak

  • SLC25A51 is a mammalian mitochondrial NAD + transporter

    Timothy S. Luongo;Jared M. Eller;Mu Jie Lu;Marc Niere

  • Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

    Xiaobing Du;Johnny Shen;Nishan Kugan;Emma E. Furth

  • DNA damage-induced type I interferon promotes senescence and inhibits stem cell function

    Qiujing Yu;Yuliya V. Katlinskaya;Christopher J. Carbone;Bin Zhao

  • Nucleolar localization of the Werner syndrome protein in human cells

    Robert A. Marciniak;David B. Lombard;F. Bradley Johnson;Leonard Guarente

  • Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging.

    S. Imai;F.B. Johnson;R.A. Marciniak;M. Mcvey

  • Association of the Bloom Syndrome Protein with Topoisomerase IIIα in Somatic and Meiotic Cells

    F. Brad Johnson;F. Brad Johnson;David B. Lombard;Norma F. Neff;Mary Ann Mastrangelo

  • Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment

    Julie Norseen;F. Brad Johnson;Paul M. Lieberman

  • Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

    Jay E. Johnson;Kajia Cao;Paul Ryvkin;Li-San Wang

  • Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

    Jay E. Johnson;F. Brad Johnson

  • Evidence for BLM and Topoisomerase IIIα interaction in genomic stability

    Peng Hu;Sergey F. Beresten;Anja J. Van Brabant;Tian-Zhang Ye

  • HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.

    Katherine M. Aird;Osamu Iwasaki;Andrew V. Kossenkov;Hideki Tanizawa

  • Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.

    Robert J. Pignolo;Robin K. Suda;Emily A. Mcmillan;Johnny Shen

Frequent Co-Authors

Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Li-San Wang
Li-San Wang University of Pennsylvania
Christopher J. Lengner
Christopher J. Lengner University of Pennsylvania
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
Brian D. Gregory
Brian D. Gregory University of Pennsylvania
Nancy M. Bonini
Nancy M. Bonini University of Pennsylvania
Carl H. June
Carl H. June University of Pennsylvania
Dimitri S. Monos
Dimitri S. Monos Children's Hospital of Philadelphia

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