2013 - Member of the National Academy of Sciences
The scientist’s investigation covers issues in Molecular biology, Somatic hypermutation, Antibody, Antigen and Genetics. Michael S. Neuberger interconnects Enhancer and Transfection in the investigation of issues within Molecular biology. His research investigates the connection between Somatic hypermutation and topics such as MSH2 that intersect with problems in Mutation Accumulation, Mutation Fixation, Germinal center and MSH6.
His work focuses on many connections between Antibody and other disciplines, such as Receptor, that overlap with his field of interest in Isotype, Glycosylation and Autoantibody. Michael S. Neuberger has researched Antigen in several fields, including Immunoglobulin E and B-cell receptor. The concepts of his Immunoglobulin light chain study are interwoven with issues in Monoclonal antibody, Peptide sequence, Myeloma protein and Hypervariable region.
Molecular biology, Somatic hypermutation, Antibody, Genetics and Gene are his primary areas of study. Michael S. Neuberger combines subjects such as Immunoglobulin gene, Transgene, B cell, Antigen and Immunoglobulin light chain with his study of Molecular biology. The various areas that Michael S. Neuberger examines in his Antigen study include B-cell receptor, B-1 cell and Cell biology.
His Somatic hypermutation study also includes fields such as
His main research concerns Somatic hypermutation, Genetics, Molecular biology, Immunoglobulin class switching and Cytidine deaminase. DNA deamination is the focus of his Somatic hypermutation research. His Molecular biology research incorporates themes from DNA glycosylase, Immunoglobulin heavy chain, Immunoglobulin G, Deamination and B cell.
His study with Immunoglobulin G involves better knowledge in Antibody. His Cytidine deaminase study combines topics in areas such as Cytidine, Activation-induced deaminase and Protein degradation. His Endogeny research includes themes of Epitope, Affinity maturation, Antigen, Immunoglobulin M and Monoclonal antibody.
His primary scientific interests are in Somatic hypermutation, Genetics, APOBEC Deaminases, Molecular biology and Immunoglobulin class switching. His Somatic hypermutation research integrates issues from Mutation and DNA glycosylase. His study of Cytidine deaminase is a part of Genetics.
His APOBEC Deaminases study incorporates themes from APOBEC3A, Cytidine deamination and APOBEC1. As part of his studies on Molecular biology, Michael S. Neuberger often connects relevant areas like Deamination. His Immunoglobulin class switching study integrates concerns from other disciplines, such as Uracil-DNA glycosylase and Antibody Diversity.
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Replacing the complementarity-determining regions in a human antibody with those from a mouse
Peter T. Jones;Paul H. Dear;Jefferson Foote;Michael S. Neuberger.
DNA deamination mediates innate immunity to (retro)viral infection
Michael Malim;Ann Sheehy;Reuben Harris;Kate Bishop.
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
Svend K. Petersen-Mahrt;Reuben S. Harris;Michael S. Neuberger.
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.
M Brüggemann;G T Williams;C I Bindon;M R Clark.
Journal of Experimental Medicine (1987)
Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice
Cristina Rada;Gareth T. Williams;Hilde Nilsen;Deborah E Barnes.
Current Biology (2002)
Hyperresponsive B Cells in CD22-Deficient Mice
Theresa L. O'Keefe;Gareth T. Williams;Sarah L. Davies;Michael S. Neuberger.
B cells acquire antigen from target cells after synapse formation.
Facundo D. Batista;Dagmar Iber;Michael S. Neuberger.
Recombinant antibodies possessing novel effector functions
Michael S. Neuberger;Gareth T. Williams;Robert O. Fox.
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.
Reuben S. Harris;Svend K. Petersen-Mahrt;Michael S. Neuberger.
Molecular Cell (2002)
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
Javier Di Noia;Michael S. Neuberger.
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