What is he best known for?
The fields of study he is best known for:
Cesar Milstein mainly focuses on Antibody, Molecular biology, Genetics, Gene and Monoclonal antibody.
Cesar Milstein has researched Antibody in several fields, including Immune system and Antigen.
His Molecular biology research includes themes of Epitope, Antibody variation, Biochemistry and Immunoglobulin E.
His work on Mutation, Gene rearrangement, Exon and 2-phenyloxazolone as part of his general Genetics study is frequently connected to D region, thereby bridging the divide between different branches of science.
His work focuses on many connections between Gene and other disciplines, such as Somatic hypermutation, that overlap with his field of interest in Transgene, Nucleotide substitution and Mutational hotspot.
His Monoclonal study in the realm of Monoclonal antibody connects with subjects such as Allelic exclusion.
His most cited work include:
- Reshaping human antibodies: grafting an antilysozyme activity (1337 citations)
- Man-made antibodies (1074 citations)
- Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody (966 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Molecular biology, Antibody, Genetics, Antigen and Gene.
His Molecular biology research is multidisciplinary, incorporating perspectives in Germline mutation, Biochemistry, Immunoglobulin light chain, Peptide sequence and Monoclonal antibody.
His research investigates the link between Monoclonal antibody and topics such as Human leukocyte antigen that cross with problems in Interferon.
The Antibody study combines topics in areas such as Spleen, Stereochemistry and Immune system.
His work carried out in the field of Antigen brings together such families of science as Immunoglobulin gene, Cell, Immunogen and Clone.
His Somatic hypermutation research integrates issues from Transgene, Mutation, DNA, Affinity maturation and Transcription.
He most often published in these fields:
- Molecular biology (48.17%)
- Antibody (39.63%)
- Genetics (25.61%)
What were the highlights of his more recent work (between 1993-2006)?
- Somatic hypermutation (17.68%)
- Genetics (25.61%)
- Molecular biology (48.17%)
In recent papers he was focusing on the following fields of study:
Cesar Milstein mostly deals with Somatic hypermutation, Genetics, Molecular biology, Gene and Affinity maturation.
His research in Somatic hypermutation intersects with topics in Mutation, Germline mutation, Transgene, Antigen and Transcription.
His Antigen research incorporates elements of Immunoglobulin gene, Computational biology, Monoclonal antibody and Immunoglobulin class switching.
Cesar Milstein studied Monoclonal antibody and Mhc antigens that intersect with CD1.
He has included themes like Stop codon, Mutant, B cell, Immunoglobulin light chain and Intron in his Molecular biology study.
Cesar Milstein studies Antibody, namely Antibody Diversity.
Between 1993 and 2006, his most popular works were:
- Elements regulating somatic hypermutation of an immunoglobulin κ gene : critical role for the intron enhancer/matrix attachment region (366 citations)
- Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. (334 citations)
- Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. (242 citations)
In his most recent research, the most cited papers focused on:
His primary areas of study are Somatic hypermutation, Genetics, Gene, Molecular biology and Transgene.
His Somatic hypermutation research includes themes of Mutation, Affinity maturation and Mutation Accumulation.
His Mutation study combines topics from a wide range of disciplines, such as Immunoglobulin heavy chain, Activation-induced deaminase, Cytidine deaminase, Mutation rate and Fusion protein.
Cesar Milstein has included themes like Mutagenesis and Heterologous in his Affinity maturation study.
His studies examine the connections between Gene and genetics, as well as such issues in DNA, with regards to Nucleotide, Coding strand and Recombinant DNA.
His Molecular biology research is multidisciplinary, incorporating perspectives in Enhancer and Germline mutation.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
