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Immunology

D-Index
61
Citations
20406
World Ranking
3194
National Ranking
272

Overview

Michael R. Ehrenstein is affiliated with University College London in the United Kingdom. Their research predominantly spans the fields of Medicine and Immunology and Microbiology, with a notable focus on Rheumatology and Immunology as subfields of study. Specific areas of interest include Systemic Lupus Erythematosus Research, T-cell and B-cell Immunology, and Monoclonal and Polyclonal Antibodies Research.

The scientist's work encompasses various subjects related to autoimmune and inflammatory disorders, rheumatoid arthritis research and therapies, chronic lymphocytic leukemia research, and lymphoma diagnosis and treatment.

Michael R. Ehrenstein has been published in several academic venues, with frequent publications in the following journals:

  • Annals of the Rheumatic Diseases
  • Lara D. Veeken
  • The Lancet Rheumatology
  • Scientific Reports
  • The Science of The Total Environment

Some of their recent papers include:

  • "Optimising fuel supply chains within planetary boundaries: A case study of hydrogen for road transport in the UK" (2020, Applied Energy)
  • "M3C: Monte Carlo reference-based consensus clustering" (2020, Scientific Reports)
  • "Unraveling the links between public spending and Sustainable Development Goals: Insights from data envelopment analysis" (2021, The Science of The Total Environment)
  • "Efficacy and safety of obinutuzumab in systemic lupus erythematosus patients with secondary non-response to rituximab" (2022, Lara D. Veeken)
  • "Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials" (2023, The Lancet Rheumatology)

They have collaborated frequently with several co-authors, including:

  • Muhammad Shipa
  • Su-Ann Yeoh
  • Caroline Gordon
  • Edward M Vital
  • Peter Hewins

Best Publications

  • CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

    Paul A. Blair;Lina Yassin Noreña;Fabian Flores-Borja;David J. Rawlings

  • Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

    Michael R. Ehrenstein;Jamie G. Evans;Animesh Singh;Samantha Moore

  • An open study of B lymphocyte depletion in systemic lupus erythematosus

    Maria J. Leandro;Jonathan C. Edwards;Geraldine Cambridge;Michael R. Ehrenstein

  • CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation.

    Fabian Flores-Borja;Anneleen Bosma;Dorothy Ng;Venkat Reddy

  • The importance of natural IgM: scavenger, protector and regulator

    Michael R. Ehrenstein;Clare A. Notley

  • Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis

    Jamie G. Evans;Karina A. Chavez-Rueda;Ayad Eddaoudi;Almut Meyer-Bahlburg

  • Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis

    Maria J. Leandro;Geraldine Cambridge;Michael R. Ehrenstein;Jonathan C. W. Edwards

  • Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.

    Suchita Nadkarni;Claudia Mauri;Michael R. Ehrenstein

  • Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis.

    Geraldine Cambridge;Maria J Leandro;Jonathan C W Edwards;Michael R Ehrenstein

  • Mice Lacking Endogenous IL-10–Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells

    Natalie A. Carter;Rita Vasconcellos;Elizabeth C. Rosser;Calogero Tulone

  • The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

    Jeremy S. Brown;Tracy Hussell;Sarah M. Gilliland;David W. Holden

  • B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients

    M. J. Leandro;G. Cambridge;J. C. Edwards;M. R. Ehrenstein

  • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.

    Cristina Rada;Michael R. Ehrenstein;Michael S. Neuberger;César Milstein

  • Human FoxP3+ regulatory T cells in systemic autoimmune diseases

    Makoto Miyara;Guy Gorochov;Michael Ehrenstein;Lucile Musset

  • Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/ lpr Mice

    Paul A. Blair;Karina A. Chavez-Rueda;Jamie G. Evans;Mark J. Shlomchik

  • The ‘short’ history of regulatory B cells

    Claudia Mauri;Michael R. Ehrenstein

  • Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

    Fabian Flores-Borja;Elizabeth C. Jury;Claudia Mauri;Michael R. Ehrenstein

  • Fifty years of anti-ds DNA antibodies: are we approaching journey's end?

    D. A. Isenberg;J. J. Manson;M. R. Ehrenstein;A. Rahman

  • Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response

    Michael R. Ehrenstein;Theresa L. O’Keefe;Sarah L. Davies;Michael S. Neuberger

  • International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease.

    D. A. Isenberg;E. Allen;V. Farewell;M. R. Ehrenstein

  • Cells of the synovium in rheumatoid arthritis

    Michael R Ehrenstein;Claudia Mauri

Frequent Co-Authors

David A. Isenberg
David A. Isenberg University College London
Claudia Mauri
Claudia Mauri University College London
Michael S. Neuberger
Michael S. Neuberger MRC Laboratory of Molecular Biology
Ian N. Bruce
Ian N. Bruce University of Manchester
Costantino Pitzalis
Costantino Pitzalis Queen Mary University of London
Deborah P. M. Symmons
Deborah P. M. Symmons University of Manchester
Michael R. Barnes
Michael R. Barnes Queen Mary University of London
Cesar Milstein
Cesar Milstein MRC Laboratory of Molecular Biology
Caroline Gordon
Caroline Gordon University of Birmingham
Marina Botto
Marina Botto Imperial College London

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