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Microbiology

D-Index
48
Citations
7409
World Ranking
4711
National Ranking
324

Research.com Recognitions

  • 2020 - Member of Academia Europaea

Overview

Lars Nitschke is affiliated with the University of Erlangen-Nuremberg in Germany. Their research primarily spans the fields of immunology and microbiology, biochemistry, genetics, molecular biology, and medicine. Within these broader fields, their work focuses on immunology, molecular biology, radiology, nuclear medicine and imaging, genetics, and immunology and allergy.

The main topics addressed in their research include glycosylation and glycoproteins, T-cell and B-cell immunology, galectins and cancer biology, immune cell function and interaction, monoclonal and polyclonal antibodies, immunotherapy and immune responses, and cell adhesion molecules research.

Several of their recent papers highlight areas of B cell immunology and glycosylation. Notable publications include:

  • Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo, 2020, Frontiers in Immunology
  • A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity, 2021, Nature Immunology
  • CD22 Controls Germinal Center B Cell Receptor Signaling, Which Influences Plasma Cell and Memory B Cell Output, 2021, The Journal of Immunology
  • Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages, 2021, eLife
  • Coordinated changes in glycosylation regulate the germinal center through CD22, 2022, Cell Reports

Lars Nitschke frequently collaborates with other researchers, including Carolin Brandl, Matthew S. Macauley, Sarah J. Meyer, Falk Nimmerjahn, and Amin Alborzian Deh Sheikh.

The venues in which Nitschke has published regularly include Frontiers in Immunology, The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Nature Immunology, and eLife.

In 2020, Lars Nitschke was recognized as a member of Academia Europaea.

Best Publications

  • CD22 is a negative regulator of B cell receptor signalling

    L. Nitschke;R. Carsetti;B. Ocker;G. Kohler

  • B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity

    Lily I. Pao;Kong-Peng Lam;Joel M. Henderson;Jeffery L. Kutok

  • The role of CD22 and other inhibitory co-receptors in B-cell activation.

    Lars Nitschke

  • The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.

    Jiquan Q. Zhang;Björn Biedermann;Lars Nitschke;Paul R. Crocker

  • Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population

    Anja Hoffmann;Sheena Kerr;Julia Jellusova;Jiquan Zhang

  • The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound

    Soerge Kelm;Judith Gerlach;Reinhard Brossmer;Claus-Peter Danzer

  • Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling.

    Kerry Tedford;Kerry Tedford;Lars Nitschke;Irute Girkontaite;Amanda Charlesworth

  • CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions.

    Lars Nitschke

  • Reduction of marginal zone B cells in CD22-deficient mice.

    Tatjana Samardzic;Dragan Marinkovic;Claus-Peter Danzer;Judith Gerlach

  • Immunoglobulin D-deficient Mice Can Mount Normal Immune Responses to Thymus-Independent and -Dependent Antigens

    Lars Nitschke;Marie H. Kosco;Georges Kohler;Marinus C. Lamers

  • Effect of transmembrane and cytoplasmic domains of IgE on the IgE response

    Gernot Achatz;Lars Nitschke;Marinus C. Lamers

  • CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.

    Julia Jellusova;Ute Wellmann;Kerstin Amann;Thomas H. Winkler

  • Responsiveness of B cells is regulated by the hinge region of IgD

    Rudolf Übelhart;Eva Hug;Martina P Bach;Thomas Wossning

  • Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.

    Julia Jellusova;Lars Nitschke

  • IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β

    Ari Waisman;Manfred Kraus;Jane Seagal;Snigdha Ghosh

  • NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

    Sankar Bhattacharyya;Jolly Deb;Amiya K. Patra;Duong Anh Thuy Pham

  • IDENTIFICATION OF CD22 LIGANDS ON BONE MARROW SINUSOIDAL ENDOTHELIUM IMPLICATED IN CD22-DEPENDENT HOMING OF RECIRCULATING B CELLS

    Lars Nitschke;Helen Floyd;David J.P. Ferguson;Paul R. Crocker

  • Molecular interactions regulate BCR signal inhibition by CD22 and CD72

    Lars Nitschke;Takeshi Tsubata

  • CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.

    Jennifer Müller;Ingrid Obermeier;Miriam Wöhner;Carolin Brandl

  • The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease

    Jennifer Müller;Lars Nitschke

  • Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production

    Gregory C. Ippolito;Robert L. Schelonka;Michael Zemlin;Ivaylo I. Ivanov

Frequent Co-Authors

Thomas H. Winkler
Thomas H. Winkler University of Erlangen-Nuremberg
Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine
Michael Reth
Michael Reth University of Freiburg
Christoph J. Binder
Christoph J. Binder Medical University of Vienna
Thomas Wirth
Thomas Wirth University of Ulm
Paul R. Crocker
Paul R. Crocker University of Dundee
Harry W. Schroeder
Harry W. Schroeder University of Alabama at Birmingham
James C. Paulson
James C. Paulson Scripps Research Institute
Georges Köhler
Georges Köhler Max Planck Society
Alexander Steinkasserer
Alexander Steinkasserer University of Erlangen-Nuremberg

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