2026 Taku Okazaki: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	49	4289	3962	166	149	85	33542

Overview

Taku Okazaki is affiliated with the University of Tokushima in Japan and conducts research primarily within the fields of Medicine and Immunology and Microbiology. Their work encompasses multiple subfields including Oncology, Immunology, Neurology, Molecular Biology, and Biophysics. The main topics addressed in their research include:

Cancer Immunotherapy and Biomarkers
Immune Cell Function and Interaction
CAR-T cell therapy research
Immunotherapy and Immune Responses
T-cell and B-cell Immunology
Pancreatic and Hepatic Oncology Research
Neuroblastoma Research and Treatments

Among the notable recent papers associated with Taku Okazaki are:

"LAG-3: from molecular functions to clinical applications," 2020, Journal for ImmunoTherapy of Cancer
"Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity," 2022, Immunity
"PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity," 2022, Nature Immunology
"PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation," 2020, Molecular Cell
"Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes," 2022, Proceedings of the National Academy of Sciences

The frequent coauthors collaborating with Taku Okazaki include:

Il-mi Okazaki
Takumi Maruhashi
Daisuke Sugiura
Kenji Shimizu
Tatsuya Takemoto

Common publication venues for their work are:

Proceedings of the National Academy of Sciences
Biophysics and Physicobiology
Journal for ImmunoTherapy of Cancer
Immunity
Nature Immunology

Best Publications

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.

Gordon J. Freeman;Andrew J. Long;Yoshiko Iwai;Karen Bourque

6279
Citations
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Yoshiko Iwai;Masayoshi Ishida;Yoshimasa Tanaka;Taku Okazaki

3752
Citations
PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Yvette Latchman;Clive R. Wood;Tatyana Chernova;Divya Chaudhary

3680
Citations
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

Hiroyuki Nishimura;Taku Okazaki;Yoshimasa Tanaka;Kazuki Nakatani

2255
Citations
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.

Junzo Hamanishi;Masaki Mandai;Masashi Iwasaki;Taku Okazaki

1812
Citations
PD-1 and PD-1 ligands: from discovery to clinical application.

Taku Okazaki;Tasuku Honjo

1572
Citations
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

Taku Okazaki;Akito Maeda;Hiroyuki Nishimura;Tomohiro Kurosaki

1082
Citations
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.

Taku Okazaki;Shunsuke Chikuma;Yoshiko Iwai;Sidonia Fagarasan

1010
Citations
The PD-1–PD-L pathway in immunological tolerance

Taku Okazaki;Tasuku Honjo

934
Citations
Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma†

Ryosuke Hino;Kenji Kabashima;Kenji Kabashima;Yu Kato;Hiroaki Yagi

814
Citations
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

Taku Okazaki;Yoshimasa Tanaka;Yoshimasa Tanaka;Ryosuke Nishio;Tamotsu Mitsuiye

796
Citations
Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

Hiroaki Masuzaki;Yoshihiro Ogawa;Naohi Isse;Noriko Satoh

699
Citations
Resting dendritic cells induce peripheral CD8 + T cell tolerance through PD-1 and CTLA-4

Hans Christian Probst;Kathy McCoy;Taku Okazaki;Tasuku Honjo

675
Citations
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.

David Yin-wei Lin;Yoshimasa Tanaka;Masashi Iwasaki;Apostolos G. Gittis

531
Citations
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes

Jian Wang;Taku Yoshida;Fumio Nakaki;Hiroshi Hiai

526
Citations
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

Yoshiko Iwai;Seigo Terawaki;Masaya Ikegawa;Taku Okazaki

525
Citations
LAG-3: from molecular functions to clinical applications

Takumi Maruhashi;Daisuke Sugiura;Il Mi Okazaki;Taku Okazaki

435
Citations
IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity

Seigo Terawaki;Shunsuke Chikuma;Shiro Shibayama;Tamon Hayashi

396
Citations
Structural organization and chromosomal assignment of the human obese gene.

Naohi Isse;Yoshihiro Ogawa;Naohisa Tamura;Hiroaki Masuzaki

394
Citations
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.

Masayoshi Ishida;Yoshiko Iwai;Yoshimasa Tanaka;Taku Okazaki

390
Citations
Role of PD-1 in regulating T-cell immunity.

Hyun-Tak Jin;Rafi Ahmed;Taku Okazaki

375
Citations
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

Taku Okazaki;Il-mi Okazaki;Jian Wang;Daisuke Sugiura

360
Citations
Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

Hiroaki Masuzaki;Yoshihiro Ogawa;Naohi Isse;Noriko Satoh

99
Citations

Frequent Co-Authors

Tasuku Honjo Kyoto University

Yoshimasa Tanaka Nagasaki University

Nagahiro Minato Kyoto University

Yoshihiro Ogawa Kyushu University

Hiroshi Hiai Kyoto University

Kazuwa Nakao Kyoto University

Kiyoshi Mori University of Shizuoka

Tsutomu Chiba Kyoto University

Kiminori Hosoda Kyoto University

Hiroaki Masuzaki University of the Ryukyus

External Links

Personal website of Taku Okazaki

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