His primary areas of study are Molecular biology, Cancer research, Internal medicine, Endocrinology and Immunology. His research in Molecular biology intersects with topics in Lipid peroxidation, Biochemistry, Kidney and Histidine. His Cancer research research is multidisciplinary, incorporating perspectives in Carcinogenesis, Cancer cell, Carcinoma, Pathology and Metastasis.
His work on Oxidative stress, Obesity, Secretion and Hormone as part of general Internal medicine research is frequently linked to Gastric inhibitory polypeptide receptor, bridging the gap between disciplines. He has researched Endocrinology in several fields, including Heart disease and Dilated cardiomyopathy. He combines topics linked to Cardiomyopathy with his work on Immunology.
Hiroshi Hiai mainly investigates Molecular biology, Pathology, Genetics, Carcinogenesis and Cancer research. His study in Molecular biology is interdisciplinary in nature, drawing from both Biochemistry, Antigen, Lymphoma, Antibody and Bone marrow. His Antigen research is under the purview of Immunology.
His Carcinogenesis research includes themes of Endocrinology, Carcinoma, Loss of heterozygosity and Carcinogen. In Endocrinology, Hiroshi Hiai works on issues like Messenger RNA, which are connected to Internal medicine. The various areas that Hiroshi Hiai examines in his Cancer research study include Cancer, Metastasis, Cell culture, Gene expression and Transcription factor.
His scientific interests lie mostly in Molecular biology, Carcinogenesis, Immunology, Genetics and Pathology. His Molecular biology research is multidisciplinary, incorporating elements of Congenic, Cellular differentiation, Mutant, Wild type and Gene. His biological study spans a wide range of topics, including Cancer research, Activation-induced deaminase, Cytidine deaminase, Thioredoxin and Genetically modified mouse.
His Immunology research includes elements of Xenotransplantation and Stem cell. His Antigen study combines topics in areas such as Signal transduction and Lymphoma. His research investigates the connection between Candidate gene and topics such as Allele that intersect with issues in Internal medicine.
Hiroshi Hiai spends much of his time researching Stem cell, Immunology, Molecular biology, Antigen and Autoimmune disease. His work carried out in the field of Immunology brings together such families of science as PRKDC Gene, Paneth cell and Xenotransplantation, Transplantation. His study focuses on the intersection of Molecular biology and fields such as Carcinogenesis with connections in the field of Oxidative stress, Binding protein, Messenger RNA and Thioredoxin.
In his study, Autoantibody, BALB/c and Antibody is strongly linked to Receptor, which falls under the umbrella field of Antigen. He interconnects Nod, CD28, CD8, Immune tolerance and Autoimmunity in the investigation of issues within Autoimmune disease. Hiroshi Hiai has included themes like Basic fibroblast growth factor, Endocrinology and Colitis in his Cancer research study.
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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
Hiroyuki Nishimura;Masato Nose;Hiroshi Hiai;Nagahiro Minato.
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
Hiroyuki Nishimura;Taku Okazaki;Yoshimasa Tanaka;Kazuki Nakatani.
Persistent oxidative stress in cancer
Shinya Toyokuni;Keisei Okamoto;Junji Yodoi;Hiroshi Hiai.
FEBS Letters (1995)
Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Kazumasa Miyawaki;Yuichiro Yamada;Nobuhiro Ban;Yu Ihara.
Nature Medicine (2002)
Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model
S. Toyokuni;T. Tanaka;Y. Hattori;Y. Nishiyama.
Laboratory Investigation (1997)
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.
Sidonia Fagarasan;Masamichi Muramatsu;Keiichiro Suzuki;Hitoshi Nagaoka.
Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.
Y Ihara;S Toyokuni;K Uchida;H Odaka.
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
Jian Wang;Taku Yoshida;Fumio Nakaki;Hiroshi Hiai.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8-hydroxy-2′-deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment
Marina Erhola;Shinya Toyokuni;Kunihiko Okada;Tomoyuki Tanaka.
FEBS Letters (1997)
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
H. Suwa;G. Ohshio;T. Imamura;G. Watanabe.
British Journal of Cancer (1998)
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