What is he best known for?
The fields of study he is best known for:
- Gene
- Cancer
- Internal medicine
His primary areas of study are Molecular biology, Cancer research, Internal medicine, Endocrinology and Immunology.
His research in Molecular biology intersects with topics in Lipid peroxidation, Biochemistry, Kidney and Histidine.
His Cancer research research is multidisciplinary, incorporating perspectives in Carcinogenesis, Cancer cell, Carcinoma, Pathology and Metastasis.
His work on Oxidative stress, Obesity, Secretion and Hormone as part of general Internal medicine research is frequently linked to Gastric inhibitory polypeptide receptor, bridging the gap between disciplines.
He has researched Endocrinology in several fields, including Heart disease and Dilated cardiomyopathy.
He combines topics linked to Cardiomyopathy with his work on Immunology.
His most cited work include:
- Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. (1951 citations)
- Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice (1334 citations)
- Persistent oxidative stress in cancer (1019 citations)
What are the main themes of his work throughout his whole career to date?
Hiroshi Hiai mainly investigates Molecular biology, Pathology, Genetics, Carcinogenesis and Cancer research.
His study in Molecular biology is interdisciplinary in nature, drawing from both Biochemistry, Antigen, Lymphoma, Antibody and Bone marrow.
His Antigen research is under the purview of Immunology.
His Carcinogenesis research includes themes of Endocrinology, Carcinoma, Loss of heterozygosity and Carcinogen.
In Endocrinology, Hiroshi Hiai works on issues like Messenger RNA, which are connected to Internal medicine.
The various areas that Hiroshi Hiai examines in his Cancer research study include Cancer, Metastasis, Cell culture, Gene expression and Transcription factor.
He most often published in these fields:
- Molecular biology (37.62%)
- Pathology (20.00%)
- Genetics (17.14%)
What were the highlights of his more recent work (between 2004-2017)?
- Molecular biology (37.62%)
- Carcinogenesis (16.19%)
- Immunology (14.29%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Molecular biology, Carcinogenesis, Immunology, Genetics and Pathology.
His Molecular biology research is multidisciplinary, incorporating elements of Congenic, Cellular differentiation, Mutant, Wild type and Gene.
His biological study spans a wide range of topics, including Cancer research, Activation-induced deaminase, Cytidine deaminase, Thioredoxin and Genetically modified mouse.
His Immunology research includes elements of Xenotransplantation and Stem cell.
His Antigen study combines topics in areas such as Signal transduction and Lymphoma.
His research investigates the connection between Candidate gene and topics such as Allele that intersect with issues in Internal medicine.
Between 2004 and 2017, his most popular works were:
- Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes (297 citations)
- Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases (222 citations)
- Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas (193 citations)
In his most recent research, the most cited papers focused on:
Hiroshi Hiai spends much of his time researching Stem cell, Immunology, Molecular biology, Antigen and Autoimmune disease.
His work carried out in the field of Immunology brings together such families of science as PRKDC Gene, Paneth cell and Xenotransplantation, Transplantation.
His study focuses on the intersection of Molecular biology and fields such as Carcinogenesis with connections in the field of Oxidative stress, Binding protein, Messenger RNA and Thioredoxin.
In his study, Autoantibody, BALB/c and Antibody is strongly linked to Receptor, which falls under the umbrella field of Antigen.
He interconnects Nod, CD28, CD8, Immune tolerance and Autoimmunity in the investigation of issues within Autoimmune disease.
Hiroshi Hiai has included themes like Basic fibroblast growth factor, Endocrinology and Colitis in his Cancer research study.
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