Georges Köhler

Research.com Recognitions

• 1984 - Nobel Prize for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies
• 1984 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
• 1982 - Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB)
• 1981 - Canada Gairdner International Award
• 1963 - Fellow of the American Association for the Advancement of Science (AAAS)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)

Overview

Best Publications

• Impaired immune and acute-phase responses in interleukin-6-deficient mice

  Manfred Kopf;Heinz Baumann;Giulia Freer;Marina Freudenberg

  2622
  Citations

• Disruption of the murine IL-4 gene blocks Th2 cytokine responses

  M Kopf;G Le Gros;M Bachmann;M C Lamers

  1558
  Citations

• IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

  Manfred Kopf;Frank Brombacher;Philip D Hodgkin;Alistair J Ramsay

  739
  Citations

• CD22 is a negative regulator of B cell receptor signalling

  L. Nitschke;R. Carsetti;B. Ocker;G. Kohler

  536
  Citations

• Transitional B cells are the target of negative selection in the B cell compartment.

  Rita Carsetti;Georges Köhler;Marinus C. Lamers

  523
  Citations

• Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

  L Hendershot;D Bole;G Köhler;J F Kearney

  456
  Citations

• Negative feedback regulation of IgE synthesis by murine CD23

  Philipp Yu;Marie Kosco-Vilbois;Mark Richards;Georges Köhler

  367
  Citations

• Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line.

  Sandro Rusconi;Sandro Rusconi;Georges Köhler;Georges Köhler

  344
  Citations

• The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.

  M. Terashima;Kwang-Myong Kim;T. Adachi;P. J. Nielsen

  339
  Citations

• Impaired mucosal immune responses in interleukin 4-targeted mice.

  M Vajdy;M H Kosco-Vilbois;M Kopf;G Köhler

  273
  Citations

• IgD can largely substitute for loss of IgM function in B cells

  Claudia Lutz;Birgit Ledermann;Marie H. Kosco-Vilbois;Adrian F. Ochsenbein

  199
  Citations

• Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice

  Manfred Kopf;Graham Le Gros;Anthony J. Coyle;Marie Kosco-Vtlbois

  198
  Citations

• Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line

  Nancy Noben-Trauth;Georges Köhler;Kurt Bürki;Birgit Ledermann

  190
  Citations

• Schistosoma mansoni in IL-4-deficient mice

  Edward J. Pearce;Allen Cheever;Susan Leonard;Maria Covalesky

  178
  Citations

• The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice.

  Thierry von der Weid;Manfred Kopf;Georges Köhler;Jean Langhorne

  169
  Citations

• Immunoglobulin D-deficient Mice Can Mount Normal Immune Responses to Thymus-Independent and -Dependent Antigens

  Lars Nitschke;Marie H. Kosco;Georges Kohler;Marinus C. Lamers

  168
  Citations

• Two new proteins preferentially associated with membrane immunoglobulin D.

  Kwang-Myong Kim;T. Adachi;P. J. Nielsen;M. Terashima

  155
  Citations

• Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice.

  P.J. Nielsen;B. Lorenz;A.M. Müller;R.H. Wenger

  149
  Citations

• Monoclonal antibodies specific for murine IgM. I: Characterization of antigenic determinants on the four constant domains of the μ heavy chain

  Maria Leptin;Maria Leptin;Mary Jane Potash;Rudolf Grützmann;Christoph Heusser

  138
  Citations

• A role for immunoglobulin D: interference with tolerance induction.

  Rita Carsetti;Georges Köhler;Marinus C. Lamers

  129
  Citations