World's Best Scientists 2026 revealed!
Manfred Kopf

Manfred Kopf

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Immunology
Switzerland
2026

D-Index & Metrics

Immunology

D-Index
116
Citations
44180
World Ranking
384
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Immunology in Switzerland Leader Award
  • 2025 - Research.com Immunology in Switzerland Leader Award
  • 2022 - Research.com Immunology in Switzerland Leader Award

Overview

Manfred Kopf is affiliated with ETH Zurich in Switzerland and has contributed extensively to the fields of immunology, microbiology, biochemistry, genetics, molecular biology, and medicine. Their research spans several key subfields, including immunology, molecular biology, epidemiology, pulmonary and respiratory medicine, and oncology.

The scientist's recent publications reflect a focus on immune cell function, metabolic regulation, and tissue homeostasis. Notable papers include:

  • Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization, 2020, Cell Metabolism
  • Redox regulation of immunometabolism, 2020, Nature Reviews Immunology
  • A guideline on the molecular ecosystem regulating ferroptosis, 2024, Nature Cell Biology
  • In vivo prime editing of a metabolic liver disease in mice, 2022, Science Translational Medicine
  • Tissue-resident macrophages: guardians of organ homeostasis, 2021, Trends in Immunology

Frequent coauthors include:

  • Luigi Tortola
  • Jonathan Muri
  • Mai Matsushita
  • Lea Pohlmeier
  • Federica Piattini

Manfred Kopf publishes regularly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Journal of Immunology
  • Nature Communications
  • The Journal of Experimental Medicine
  • Nature Immunology

Main research topics addressed in their work are:

  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • Phagocytosis and Immune Regulation
  • Immunotherapy and Immune Responses
  • Immune Response and Inflammation
  • Genomics, phytochemicals, and oxidative stress
  • Epigenetics and DNA Methylation

Best Publications

  • Impaired immune and acute-phase responses in interleukin-6-deficient mice

    Manfred Kopf;Heinz Baumann;Giulia Freer;Marina Freudenberg

  • Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

    Yumiko Imai;Keiji Kuba;Keiji Kuba;G. Greg Neely;Rubina Yaghubian-Malhami

  • Disruption of the murine IL-4 gene blocks Th2 cytokine responses

    M Kopf;G Le Gros;M Bachmann;M C Lamers

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

    Manfred Kopf;Frank Brombacher;Philip D Hodgkin;Alistair J Ramsay

  • Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

    Monika Julia Wolf;Arlind Adili;Kira Piotrowitz;Zeinab Abdullah

  • IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.

    Teresa Zelante;Antonella De Luca;Pierluigi Bonifazi;Claudia Montagnoli

  • The role of interleukin-6 in mucosal IgA antibody responses in vivo

    Alistair J. Ramsay;Alan J. Husband;Ian A. Ramshaw;Shisan Bao

  • Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

    Christoph Schneider;Samuel P Nobs;Michael Kurrer;Hubert Rehrauer

  • T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

    Mai Matsushita;Stefan Bernd Freigang;Christoph Schneider;Marcus Conrad

  • Interleukin 6 Plays a Key Role in the Development of Antigen-Induced Arthritis

    Shiro Ohshima;Yukihiko Saeki;Toru Mima;Mitsuko Sasai

  • The development and function of lung-resident macrophages and dendritic cells

    Manfred Kopf;Christoph Schneider;Samuel P Nobs

  • IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

    Anja Fröhlich;Jan Kisielow;Iwana Schmitz;Stefan Freigang

  • Interleukin-6 Gene-Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia

    Tom van der Poll;Christopher V. Keogh;Xavier Guirao;Wim A. Buurman

  • Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity.

    Urs Eriksson;Romeo Ricci;Lukas Hunziker;Michael O Kurrer

  • Lethal tuberculosis in interleukin-6-deficient mutant mice.

    Christoph H. Ladel;Carmen Blum;Anja Dreher;Kurt Reifenberg

  • Malarial hemozoin is a Nalp3 inflammasome activating danger signal.

    Catherine Dostert;Greta Guarda;Jackeline F. Romero;Philippe Menu

  • Interleukin-1 Is Responsible for Acute Lung Immunopathology but Increases Survival of Respiratory Influenza Virus Infection

    Nicole Schmitz;Michael Kurrer;Martin F. Bachmann;Manfred Kopf

  • A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

    Johannes Haybaeck;Nicolas Zeller;Monika Julia Wolf;Achim Weber

  • Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

    A J Coyle;G Le Gros;C Bertrand;S Tsuyuki

Frequent Co-Authors

Martin F. Bachmann
Martin F. Bachmann University of Bern
Benjamin J. Marsland
Benjamin J. Marsland Monash University
Josef M. Penninger
Josef M. Penninger University of British Columbia
Frank Brombacher
Frank Brombacher University of Cape Town
Georges Köhler
Georges Köhler Max Planck Society
Nicola L. Harris
Nicola L. Harris Monash University
Gabriele Köhler
Gabriele Köhler University of Münster
Sabine Werner
Sabine Werner ETH Zurich
Luigina Romani
Luigina Romani University of Perugia

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