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Eric W. Klee

Eric W. Klee

D-Index & Metrics

Molecular Biology

D-Index
55
Citations
10975
World Ranking
2274
National Ranking
1120

Overview

Eric W. Klee is a researcher affiliated with the Mayo Clinic in the United States. Their work primarily spans the fields of biochemistry, genetics, and molecular biology, with notable contributions in medicine. Over their career, they have produced a significant body of research focused on genetics and molecular biology, contributing to subfields such as genetics, molecular biology, pulmonary and respiratory medicine, cancer research, and surgery.

The scientist has concentrated on topics including genomics and rare diseases, genetics and neurodevelopmental disorders, genomic variations and chromosomal abnormalities, cancer genomics and diagnostics, epigenetics and DNA methylation, chronic lymphocytic leukemia research, and RNA modifications and cancer.

Eric W. Klee's frequent publication venues include:

  • Genetics in Medicine Open
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genetics in Medicine
  • The American Journal of Human Genetics
  • American Journal of Medical Genetics Part A

Co-authors who have regularly collaborated with Eric W. Klee include:

  • Filippo Pinto e Vairo
  • Erica L. Macke
  • Brendan C. Lanpher
  • Gavin R. Oliver
  • Rory J. Olson

Some recent papers reflecting their research focus are:

  • Genome-wide detection of tandem DNA repeats that are expanded in autism, 2020, Nature
  • Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development, 2020, Neuron
  • Best practices for the analytical validation of clinical whole-genome sequencing intended for the diagnosis of germline disease, 2020, npj Genomic Medicine
  • Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome, 2021, Nature Genetics
  • One in seven pathogenic variants can be challenging to detect by NGS: an analysis of 450,000 patients with implications for clinical sensitivity and genetic test implementation, 2021, Genetics in Medicine

Best Publications

  • Standards and Guidelines for Validating Next-Generation Sequencing Bioinformatics Pipelines: A Joint Recommendation of the Association for Molecular Pathology and the College of American Pathologists.

    Somak Roy;Christopher Coldren;Arivarasan Karunamurthy;Nefize S. Kip

  • Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

    Mitesh J. Borad;Mia D. Champion;Jan B. Egan;Winnie S. Liang

  • Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol.

    Suzette J. Bielinski;Janet E. Olson;Jyotishman Pathak;Richard M. Weinshilboum

  • AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

    Vincenzo Salpietro;Vincenzo Salpietro;Vincenzo Salpietro;Christine L Dixon;Hui Guo;Hui Guo;Oscar D Bello

  • Genome-wide detection of tandem DNA repeats that are expanded in autism.

    Brett Trost;Worrawat Engchuan;Charlotte M. Nguyen;Charlotte M. Nguyen;Bhooma Thiruvahindrapuram

  • Maple syrup urine disease: mechanisms and management

    Patrick R Blackburn;Jennifer M Gass;Filippo Pinto e Vairo;Kristen M Farnham

  • Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

    Gwen Lomberk;Yuna Blum;Rémy Nicolle;Asha Nair

  • Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.

    Yuan Ji;Jennifer M. Skierka;Joseph H. Blommel;Brenda E. Moore

  • 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer

    Yan W. Asmann;Eric W. Klee;E. Aubrey Thompson;Edith A. Perez

  • Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development

    Ashley L. Lennox;Mariah L. Hoye;Ruiji Jiang;Bethany L. Johnson-Kerner

  • Sentieon DNASeq Variant Calling Workflow Demonstrates Strong Computational Performance and Accuracy.

    Katherine Irene Kendig;Saurabh Baheti;Matthew A Bockol;Travis M Drucker

  • Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice

    Gaurav Aggarwal;Vijaya Ramachandran;Naureen Javeed;Thiruvengadam Arumugam

  • Bioinformatics for Clinical Next Generation Sequencing

    Gavin R. Oliver;Steven N. Hart;Eric W. Klee

  • Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma

    Rachael A Vaubel;Shulan Tian;Dioval Remonde;Mark A. Schroeder

  • Clinical spectrum and genotype–phenotype associations of KCNA2-related encephalopathies

    Silvia Masnada;Ulrike B S Hedrich;Elena Gardella;Julian Schubert

  • Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.

    Hsiang Chih Lu;Hsiang Chih Lu;Qiumin Tan;Maxime W.C. Rousseaux;Wei Wang

  • Global methylation profiling for risk prediction of prostate cancer

    Saswati Mahapatra;Eric W. Klee;Charles Y.F. Young;Zhifu Sun

  • LC-MS/MS Quantification of Zn-α2 Glycoprotein: A Potential Serum Biomarker for Prostate Cancer

    Olga P. Bondar;David R. Barnidge;Eric W. Klee;Brian J. Davis

  • Zebrafish: a model for the study of addiction genetics

    Eric W. Klee;Henning Schneider;Karl J. Clark;Margot A. Cousin

  • Confirming Variants in Next-Generation Sequencing Panel Testing by Sanger Sequencing

    Linnea M. Baudhuin;Susan A. Lagerstedt;Eric W. Klee;Numrah Fadra

Frequent Co-Authors

Raul Urrutia
Raul Urrutia Medical College of Wisconsin
Eric D. Wieben
Eric D. Wieben Mayo Clinic
George G. Klee
George G. Klee Mayo Clinic
Stephen C. Ekker
Stephen C. Ekker Mayo Clinic
George Vasmatzis
George Vasmatzis Mayo Clinic
Yan W. Asmann
Yan W. Asmann Mayo Clinic
Eva Morava
Eva Morava Mayo Clinic
Ingo Helbig
Ingo Helbig Children's Hospital of Philadelphia
Evan E. Eichler
Evan E. Eichler University of Washington

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