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Stephen C. Ekker

Stephen C. Ekker

D-Index & Metrics

Genetics

D-Index
69
Citations
22108
World Ranking
2324
National Ranking
1048

Overview

Stephen C. Ekker is affiliated with the Mayo Clinic in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research encompasses several subfields including molecular biology, genetics, cell biology, oncology, and physiology.

The main topics of their research include:

  • CRISPR and Genetic Engineering
  • Mitochondrial Function and Pathology
  • Virus-based gene therapy research
  • Zebrafish Biomedical Research Applications
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • Metabolism and Genetic Disorders

Stephen C. Ekker has published numerous papers in various scientific venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Journal of Clinical and Translational Science
  • Developmental Dynamics
  • PubMed

Some of their recent papers are:

  • Efficient targeted integration directed by short homology in zebrafish and mammalian cells, 2020, eLife
  • The NIH Somatic Cell Genome Editing program, 2021, Nature
  • GeneWeld: Efficient Targeted Integration Directed by Short Homology in Zebrafish, 2021, BIO-PROTOCOL
  • Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish, 2021, eLife
  • The FusX TALE Base Editor (FusXTBE) for Rapid Mitochondrial DNA Programming of Human Cells In Vitro and Zebrafish Disease Models In Vivo, 2021, PubMed

Collaborative work has been an important aspect of their research, with frequent co-authors including:

  • Karl J. Clark
  • Ankit Sabharwal
  • Maura McGrail
  • Santiago Restrepo-Castillo
  • Brandon W. Simone

Stephen C. Ekker's research reflects a strong focus on gene editing technologies and model organisms, particularly zebrafish, as well as applications in mitochondrial biology and genetic therapies. Their body of work spans experimental techniques and applied biomedical research, involving both molecular and cellular biological approaches.

Best Publications

  • Effective targeted gene ‘knockdown’ in zebrafish

    Aidas Nasevicius;Stephen C. Ekker

  • p53 Activation by Knockdown Technologies

    Mara E Robu;Jon D Larson;Aidas Nasevicius;Aidas Nasevicius;Soraya Beiraghi

  • In vivo genome editing using a high-efficiency TALEN system

    Victoria M. Bedell;Ying Wang;Jarryd M. Campbell;Tanya L. Poshusta

  • Autoproteolysis in hedgehog protein biogenesis.

    J. J. Lee;S. C. Ekker;D. P. Von Kessler;J. A. Porter

  • Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

    Stephen C. Ekker;Anne R. Ungar;Penny Greenstein;Doris P. von Kessler

  • The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

    Jeffery A. Porter;Doris P. von Kessler;Stephen C. Ekker;Keith E. Young

  • Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.

    Jeffery A. Porter;Stephen C. Ekker;Woo Jin Park;Doris P. Von Kessler

  • A primer for morpholino use in zebrafish.

    Brent R. Bill;Andrew M. Petzold;Andrew M. Petzold;Karl J. Clark;Lisa A. Schimmenti

  • Mojo Hand, a TALEN design tool for genome editing applications

    Kevin L Neff;David P Argue;Alvin C Ma;Han B Lee

  • Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant.

    Aidas Nasevicius;Jon Larson;Stephen C. Ekker

  • Twisted gastrulation is a conserved extracellular BMP antagonist

    Jeffrey J. Ross;Osamu Shimmi;Peter Vilmos;Anna Petryk

  • Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

    Darius Balciunas;Kirk J Wangensteen;Andrew Wilber;Jason Bell

  • Morphant technology in model developmental systems

    Stephen C. Ekker;Jon D. Larson

  • Guidelines for morpholino use in zebrafish

    Didier Y. R. Stainier;Erez Raz;Nathan D. Lawson;Stephen C. Ekker

  • Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon.

    Ann E Davidson;Darius Balciunas;Deanna Mohn;Jennifer Shaffer

  • Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis

    S. C. Ekker;L. L. Mcgrew;Cheng-Jung Lai;J. J. Lee

  • Mammalian germ-line transgenesis by transposition

    Adam J. Dupuy;Karl Clark;Corey M. Carlson;Sabine Fritz

  • WNT5A mutations in patients with autosomal dominant Robinow syndrome.

    Anthony D. Person;Soraya Beiraghi;Christine M. Sieben;Spencer Hermanson

  • The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins

    S.C. Ekker;D.G. Jackson;D.P. von Kessler;B.I. Sun

  • Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.

    S. C. Ekker;K. E. Young;D. P. von Kessler;P. A. Beachy

Frequent Co-Authors

Eric W. Klee
Eric W. Klee Mayo Clinic
R. Scott McIvor
R. Scott McIvor University of Minnesota
Philip A. Beachy
Philip A. Beachy Stanford University
David A. Largaespada
David A. Largaespada University of Minnesota
Perry B. Hackett
Perry B. Hackett University of Minnesota
Matthias Hammerschmidt
Matthias Hammerschmidt University of Cologne
Michael A. Barry
Michael A. Barry Mayo Clinic

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