Hidetoshi Arima mainly focuses on Cyclodextrin, Conjugate, Biochemistry, Pharmacology and Dendrimer. The concepts of his Cyclodextrin study are interwoven with issues in Insulin, Biophysics, Stereochemistry and Solubility. His Cholesterol, Efflux and Caco-2 study in the realm of Biochemistry interacts with subjects such as Multidrug resistance-associated protein 2 and P-glycoprotein.
His Pharmacology research integrates issues from Drug delivery and In vivo. Hidetoshi Arima interconnects DNA, Transfection, Gene delivery, Cytotoxicity and Mannose in the investigation of issues within Dendrimer. His Cytotoxicity study incorporates themes from Asialoglycoprotein receptor, Genetic transfer and Molecular biology.
His primary areas of study are Cyclodextrin, Conjugate, Biochemistry, Dendrimer and Pharmacology. The Cyclodextrin study combines topics in areas such as Combinatorial chemistry, Stereochemistry and Solubility. The study incorporates disciplines such as Chromatography, Beta-Cyclodextrins, Stability constants of complexes and Dissolution in addition to Solubility.
His Dendrimer research incorporates themes from In vitro, Cytotoxicity, Biophysics, Transfection and Molecular biology. His In vitro research is multidisciplinary, incorporating perspectives in Liposome and Gene delivery. His study in the fields of Bioavailability, Pharmacokinetics and Drug carrier under the domain of Pharmacology overlaps with other disciplines such as Doxorubicin.
Hidetoshi Arima mostly deals with Cyclodextrin, Pharmacology, In vivo, Niemann–Pick disease, type C and Endocrinology. His Cyclodextrin study is concerned with Biochemistry in general. The study incorporates disciplines such as Lysosomal storage disease, Lipopolysaccharide, Proinflammatory cytokine and Atopic dermatitis in addition to Pharmacology.
His In vivo research is multidisciplinary, relying on both In vitro, Moiety, Targeted drug delivery and Small interfering RNA. His In vitro research focuses on Ternary complex and how it relates to Dendrimer, Stereochemistry and Blood chemistry. His research integrates issues of GM1 Gangliosidosis and Internal medicine in his study of Endocrinology.
His primary areas of study are Cyclodextrin, Pharmacology, Cholesterol, Supramolecular chemistry and Cytotoxic T cell. His Cyclodextrin research incorporates themes from Combinatorial chemistry and Stability constants of complexes. The concepts of his Pharmacology study are interwoven with issues in Lipopolysaccharide, Chemokine, Proinflammatory cytokine, Immunoglobulin E and In vivo.
His studies in Supramolecular chemistry integrate themes in fields like Copolymer, Nanotechnology, Pharmaceutical sciences, Polyrotaxane and Active ingredient. His Cytotoxic T cell study also includes fields such as
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Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins.
Hidetoshi Arima;Fumihiro Kihara;Fumitoshi Hirayama;Kaneto Uekama.
Bioconjugate Chemistry (2001)
Cyclodextrins in transdermal and rectal delivery.
Hajime Matsuda;Hidetoshi Arima.
Advanced Drug Delivery Reviews (1999)
Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins
Atsuya Yoshida;Hidetoshi Arima;Kaneto Uekama;Josef Pitha.
International Journal of Pharmaceutics (1988)
In vitro and in vivo gene transfer by an optimized α-cyclodextrin conjugate with polyamidoamine dendrimer
Fumihiro Kihara;Hidetoshi Arima;Toshihito Tsutsumi;Fumitoshi Hirayama.
Bioconjugate Chemistry (2003)
Improvement of gene delivery mediated by mannosylated dendrimer/α-cyclodextrin conjugates
Koki Wada;Hidetoshi Arima;Toshihito Tsutsumi;Yuko Chihara.
Journal of Controlled Release (2005)
Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with α-cyclodextrin
Fumihiro Kihara;Hidetoshi Arima;Toshihito Tsutsumi;Fumitoshi Hirayama.
Bioconjugate Chemistry (2002)
Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate : Alleviation of systemic side effect after oral administration
Hideki Yano;Fumitoshi Hirayama;Makoto Kamada;Hidetoshi Arima.
Journal of Controlled Release (2002)
Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA)
Toshihito Tsutsumi;Fumitoshi Hirayama;Kaneto Uekama;Hidetoshi Arima.
Journal of Controlled Release (2007)
Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats.
Hidetoshi Arima;Kiyokazu Yunomae;Kouzou Miyake;Tetsumi Irie.
Journal of Pharmaceutical Sciences (2001)
Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells
Toru Takeo;Takayuki Hoshii;Yuki Kondo;Hiroshi Toyodome.
Biology of Reproduction (2008)
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