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Hidetoshi Arima

Hidetoshi Arima

D-Index & Metrics

Chemistry

D-Index
60
Citations
10975
World Ranking
9859
National Ranking
706

Overview

Hidetoshi Arima is affiliated with Kumamoto University in Japan and has a research focus primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their scientific contributions span a diverse set of subfields including Molecular Biology, Physiology, Biomaterials, Organic Chemistry, and Hematology.

Their research addresses several complex topics, notably in Lysosomal Storage Disorders Research, Nanoparticle-Based Drug Delivery, and Carbohydrate Chemistry and Synthesis. Additional important topics covered in their work include RNA Interference and Gene Delivery, Advanced Biosensing and Bioanalysis Techniques, Autoimmune and Inflammatory Disorders Research, and Biocrusts and Microbial Ecology.

Hidetoshi Arima has published multiple papers in several venues, with a particular presence in the International Journal of Molecular Sciences, Life Sciences, Biological and Pharmaceutical Bulletin, YAKUGAKU ZASSHI, and SSRN Electronic Journal.

Recent papers by Hidetoshi Arima include:

  • Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice, 2021, International Journal of Molecular Sciences
  • Lactose-appended β-cyclodextrin as an effective nanocarrier for brain delivery, 2020, Journal of Controlled Release
  • A Mannosylated, PEGylated Albumin as a Drug Delivery System for the Treatment of Cancer Stroma Cells, 2021, Advanced Functional Materials
  • Development of an apolipoprotein E mimetic peptide-lipid conjugate for efficient brain delivery of liposomes, 2023, Drug Delivery
  • Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells, 2020, International Journal of Molecular Sciences

Frequent collaborators contributing to their body of work include Keiichi Motoyama, Taishi Higashi, Yoichi Ishitsuka, Yusei Yamada, and Katsumi Higaki, each having coauthored multiple publications with Arima.

Best Publications

  • Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins.

    Hidetoshi Arima;Fumihiro Kihara;Fumitoshi Hirayama;Kaneto Uekama

  • Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis

    Hidetoshi Arima;Hitoshi Ashida;Gen-ichi Danno

  • Cyclodextrins in transdermal and rectal delivery.

    Hajime Matsuda;Hidetoshi Arima

  • In vitro and in vivo gene transfer by an optimized α-cyclodextrin conjugate with polyamidoamine dendrimer

    Fumihiro Kihara;Hidetoshi Arima;Toshihito Tsutsumi;Fumitoshi Hirayama

  • Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins

    Atsuya Yoshida;Hidetoshi Arima;Kaneto Uekama;Josef Pitha

  • Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate : Alleviation of systemic side effect after oral administration

    Hideki Yano;Fumitoshi Hirayama;Makoto Kamada;Hidetoshi Arima

  • Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with α-cyclodextrin

    Fumihiro Kihara;Hidetoshi Arima;Toshihito Tsutsumi;Fumitoshi Hirayama

  • Improvement of gene delivery mediated by mannosylated dendrimer/α-cyclodextrin conjugates

    Koki Wada;Hidetoshi Arima;Toshihito Tsutsumi;Yuko Chihara

  • Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats.

    Hidetoshi Arima;Kiyokazu Yunomae;Kouzou Miyake;Tetsumi Irie

  • Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells

    Toru Takeo;Takayuki Hoshii;Yuki Kondo;Hiroshi Toyodome

  • Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA)

    Toshihito Tsutsumi;Fumitoshi Hirayama;Kaneto Uekama;Hidetoshi Arima

  • Improvement of Solubility and Oral Bioavailability of Rutin by Complexation with 2-Hydroxypropyl-β-cyclodextrin

    Kouzou Miyake;Hidetoshi Arima;Fumitoshi Hirayama;Masanobu Yamamoto

  • Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus.

    Hidetoshi Arima;Kiyokazu Yunomae;Fumitoshi Hirayama;Kaneto Uekama

  • Enhancing effects of cyclodextrins on nasal absorption of insulin in rats

    Tetsumi Irie;Koutarou Wakamatsu;Hidetoshi Arima;Hideaki Aritomi

  • Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier.

    Hidetoshi Arima;Ayumi Yoshimatsu;Haruna Ikeda;Ayumu Ohyama

  • Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults

    Keiji Terao;Daisuke Nakata;Hiroshi Fukumi;Gerhard Schmid

  • In Vitro and In Vivo gene delivery mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes

    Hidetoshi Arima;Shogo Yamashita;Yoshimasa Mori;Yuya Hayashi

  • Involvement of cholesterol in the inhibitory effect of dimethyl-β-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells

    Kiyokazu Yunomae;Hidetoshi Arima;Fumitoshi Hirayama;Kaneto Uekama

  • Recent Aspect of Cyclodextrin-Based Drug Delivery System

    Kaneto Uekama;Fumitoshi Hirayama;Hidetoshi Arima

  • Characterization of itraconazole/2-hydroxypropyl-β-cyclodextrin inclusion complex in aqueous propylene glycol solution

    K. Miyake;T. Irie;H. Arima;F. Hirayama

Frequent Co-Authors

Kaneto Uekama
Kaneto Uekama Sojo University
Fumitoshi Hirayama
Fumitoshi Hirayama Sojo University
Naomi Nakagata
Naomi Nakagata Kumamoto University
Seiji Okada
Seiji Okada Kumamoto University
Jun Li
Jun Li National University of Singapore
Fumio Hirata
Fumio Hirata Toyota Motor Corporation (Japan)
Toru Maruyama
Toru Maruyama Kumamoto University
Takuro Niidome
Takuro Niidome Kumamoto University
Masaki Otagiri
Masaki Otagiri Sojo University
Ken Ichi Yamamura
Ken Ichi Yamamura Kumamoto University

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