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Fumitoshi Hirayama

Fumitoshi Hirayama

D-Index & Metrics

Chemistry

D-Index
63
Citations
15093
World Ranking
8373
National Ranking
565

Overview

Fumitoshi Hirayama is a researcher affiliated with Sojo University in Japan, with a focus on biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields including molecular biology, pharmaceutical science, organic chemistry, materials chemistry, and nutrition and dietetics. The research topics frequently addressed in their publications include drug solubility and delivery systems, biochemical analysis and sensing techniques, protein purification and stability, therapeutic uses of natural elements, biocrusts and microbial ecology, metabolism and genetic disorders, as well as child nutrition and feeding issues.

Hirayama has contributed to various peer-reviewed journals, with publications in venues such as:

  • Carbohydrate Polymers
  • International Journal of Biological Macromolecules
  • Life Sciences
  • Pharmaceutics
  • Journal of Pharmacy and Pharmacology

Notable recent papers include:

  • "Effects of surface-deacetylated chitin nanofibers on non-alcoholic steatohepatitis model rats and their gut microbiota," 2020, International Journal of Biological Macromolecules
  • "Polypseudorotaxane-based supramolecular hydrogels consisting of cyclodextrins and Pluronics as stabilizing agents for antibody drugs," 2020, Carbohydrate Polymers
  • "Sacran, a sulfated polysaccharide, suppresses the absorption of lipids and modulates the intestinal flora in non-alcoholic steatohepatitis model rats," 2021, Life Sciences
  • "Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate," 2024, Pharmaceutics
  • "Study of the inclusion complexes formed between 4-phenylbutyrate and α-, β- and γ-cyclodextrin in solution and evaluation on their taste-masking properties," 2022, Journal of Pharmacy and Pharmacology

The research collaborations of Hirayama are reflected in frequent partnerships with co-authors such as Daisuke Iohara, Masaki Otagiri, Makoto Anraku, Keishi Yamasaki, and Akihiro Michihara.

This body of work illustrates a comprehensive approach to addressing biochemical and therapeutic challenges, with attention to drug delivery, molecular stability, and metabolic health conditions, contributing across multiple related disciplines.

Best Publications

  • Cyclodextrin Drug Carrier Systems.

    Kaneto Uekama;Fumitoshi Hirayama;Tetsumi Irie

  • Cyclodextrin-based controlled drug release system.

    F Hirayama;K Uekama

  • Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins.

    Hidetoshi Arima;Fumihiro Kihara;Fumitoshi Hirayama;Kaneto Uekama

  • Inclusi on complexations of steroid hormones with cyclodextrins in water and in solid phase

    K Uekama;T Fujinaga;F Hirayama;M Otagiri

  • In vitro and in vivo gene transfer by an optimized α-cyclodextrin conjugate with polyamidoamine dendrimer

    Fumihiro Kihara;Hidetoshi Arima;Toshihito Tsutsumi;Fumitoshi Hirayama

  • Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate : Alleviation of systemic side effect after oral administration

    Hideki Yano;Fumitoshi Hirayama;Makoto Kamada;Hidetoshi Arima

  • Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with α-cyclodextrin

    Fumihiro Kihara;Hidetoshi Arima;Toshihito Tsutsumi;Fumitoshi Hirayama

  • Improvement of gene delivery mediated by mannosylated dendrimer/α-cyclodextrin conjugates

    Koki Wada;Hidetoshi Arima;Toshihito Tsutsumi;Yuko Chihara

  • Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats.

    Hidetoshi Arima;Kiyokazu Yunomae;Kouzou Miyake;Tetsumi Irie

  • Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies.

    Makoto Anraku;Janusz M. Gebicki;Daisuke Iohara;Hisao Tomida

  • Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA)

    Toshihito Tsutsumi;Fumitoshi Hirayama;Kaneto Uekama;Hidetoshi Arima

  • Improvement of Solubility and Oral Bioavailability of Rutin by Complexation with 2-Hydroxypropyl-β-cyclodextrin

    Kouzou Miyake;Hidetoshi Arima;Fumitoshi Hirayama;Masanobu Yamamoto

  • Determination of the Stability Constants for Inclusion Complexes of Cyclodextrins with Various Drug Molecules by High Performance Liquid Chromatography

    Kaneto Uekama;Fumitoshi Hirayama;Shouzo Nasu;Naoki Matsuo

  • Colon-Specific Drug Delivery Based on a Cyclodextrin Prodrug: Release Behavior of Biphenylylacetic Acid from Its Cyclodextrin Conjugates in Rat Intestinal Tracts after Oral Administration

    Kunihiro Minami;Fumitoshi Hirayama;Kaneto Uekama

  • Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus.

    Hidetoshi Arima;Kiyokazu Yunomae;Fumitoshi Hirayama;Kaneto Uekama

  • Studies on the Antitumor Bisabolane Sesquiterpenoids Isolated from Curcuma xanthorrhiza

    Hideji Itokawa;Fusayoshi Hirayama;Kazuko Funakoshi;Koichi Takeya

  • Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation.

    Kaneto Uekama;Toshio Fujinaga;Fumitoshi Hirayama;Masaki Otagiri

  • Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation

    K. Uekama;S. Narisawa;F. Hirayama;M. Otagiri

  • 6A-O-[(4-Biphenylyl)acetyl]-α-, -β-, and -γ-cyclodextrins and 6A-deoxy-6A-[[(4-biphenylyl)acetyl]amino] -α-, -β-, and -γ-cyclodextrins : Potential prodrugs for colon-specific delivery

    Kaneto Uekama;Kunihiro Minami;Fumitoshi Hirayama

  • Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults

    Keiji Terao;Daisuke Nakata;Hiroshi Fukumi;Gerhard Schmid

  • In Vitro and In Vivo gene delivery mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes

    Hidetoshi Arima;Shogo Yamashita;Yoshimasa Mori;Yuya Hayashi

Frequent Co-Authors

Kaneto Uekama
Kaneto Uekama Sojo University
Hidetoshi Arima
Hidetoshi Arima Kumamoto University
Masaki Otagiri
Masaki Otagiri Sojo University
Toru Maruyama
Toru Maruyama Kumamoto University
Wolfram Saenger
Wolfram Saenger Freie Universität Berlin
Janusz M. Gebicki
Janusz M. Gebicki Macquarie University
Jun Li
Jun Li National University of Singapore
Kensuke Miyake
Kensuke Miyake Tokyo University of Science
Hideomi Koinuma
Hideomi Koinuma Tokyo Institute of Technology
George M. Sheldrick
George M. Sheldrick University of Göttingen

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